Roy Kolkman

 

 


 

 

 

 

 

 

Project Title

Photoacoustic imaging & Spectroscopy

Project Goals

Monitoring & quantification of blood vessel growth (angiogenesis)

Estimation of local oxygenation in tissue

Project Summary

Blood vessels play a key role in homeostasis, growth and repair of tissue. Knowledge on the presence of blood vessels, the content of hemoglobin and its degree of oxygenation, yield crucial information regarding the ability of tissue to heal or of the tumor to sustain itself and grow. The effect of therapies based on blood vessel targeting drugs can primarily be judged from the response of the vascular bed.

A promising new technique to obtain both anatomical and functional information about the vascular bed is photoacoustic imaging. Photoacoustic imaging potentially yields insight into the vascular system, its dynamics and its response to external stimuli such as drugs that cannot be obtained with other techniques. In this project we want to employ photoacoustic imaging to monitor the growth of new blood vessels (angiogenesis). In addition we want to add spectroscopy to photoacoustic imaging to reveal information about the oxygenation of the blood.

Picture 1

Photoacoustic image of vessels in the wrist of a human volunteer - Kolkman et.al., Journal Biomedical optics, 9 (6), 1327-1335, 2004