Bio sketch :
F.A. received an undergraduate education in mathematics and physics from the Lycée Louis-le-Grand and the Ecole Polytechnique in Paris -1985. He then switched for 8 years to biology starting with a master degree in biochemistry, and in cell and molecular biology. He did his PhD research in cellular immunology at the Hopital Necker and the College de France in Paris -1991-, trying to understand the interplay between cell-cell adhesion and antigen recognition. After a first post-doctoral research in immunogenetics at the Pasteur Institute, he headed the research team of a start-up company to develop diagnostic tools for detecting rare cells in the blood. He then joined Princeton university to continue his training back to experimental physics –polymer physics. He was hired in 1995 by the CNRS at the laboratory of theoretical physics of the ESPCI in Paris, and started his research at the interface of physics and cell biology. He has been leading for 15 years a multidisciplinary research group at the physics department of the Curie Institut in Paris, and his current research interests include optics, non-linear optical techniques, cytoskeleton physics, cell-cell adhesion, and the sociology of cancer-stroma cells. He is strongly involved in biological physics education, in the development of the MD-PhD track in France and teaching physics to future clinical scientists.
Some references :
- Reffay, M., et al., Collective migration driven by leader cells : interplay between RhoA and mechanical forces. Nat. Cell Biol., 2014. accepted.
- Caillé, A., F. Artzner, and F. Amblard, Ordered stacking of F-actin layers and mixed lipid bilayers: A columnar liquid crystal. Phys Rev Lett, 2013. 113(4): p. 000.
- Diakite, M.L., et al., A low-cost, label-free DNA detection method in lab-on-chip format based on electrohydrodynamic instabilities, with application to long-range PCR. Lab Chip, 2012. 12(22): p. 4738-47.
- Henry, E., et al., Crystallization of fluorescent quantum dots within a three-dimensional bio-organic template of actin filaments and lipid membranes. Nano Lett, 2011. 11(12): p. 5443-8.
- Maugis, B., et al., Dynamic instability of the intracellular pressure drives bleb-based motility. J Cell Sci, 2010. 123(Pt 22): p. 3884-92.
- Brugues, J., et al., Dynamical organization of the cytoskeletal cortex probed by micropipette aspiration. Proc Natl Acad Sci U S A, 2010. 107(35): p. 15415-20.
-de Beco, S., et al., Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc Natl Acad Sci U S A, 2009. 106(17): p. 7010-5.
- Leray, A., et al., Spatially distributed two-photon excitation fluorescence in scattering media: experiments and time-resolved Monte-Carlo simulations. Optics Communications, 2006. 272(1): p. 269-278.
- Waharte, F., et al., A two-photon FRAP analysis of the cytoskeleton dynamics in the microvilli of intestinal cells. Biophys J, 2005. 88(2): p. 1467-78.
- Hugues, S., et al., Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. Nat Immunol, 2004. 5(12): p. 1235-42.
- Le Goff, L., et al., Tracer studies on f-actin fluctuations. Phys Rev Lett, 2002. 89(25): p. 258101.
- Le Goff, L., F. Amblard, and E.M. Furst, Motor-driven dynamics in actin-myosin networks. Phys Rev Lett, 2002. 88(1): p. 018101.
- Coscoy, S., et al., Molecular analysis of microscopic ezrin dynamics by two-photon FRAP. Proc Natl Acad Sci U S A, 2002. 99(20): p. 12813-8.
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