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Abstract François Amblard

"Visible and infrared thermal pulse microscopy :

imaging - detection of pigmented cancer cells".

Abstract :

Most absorbing biomolecules are poor candidates for fluorescence contrast microscopy because they undergo fast non-radiative decay. For condensed absorbers such as microparticles, this decay leads to a transient temperature jump, and therefore to a short pulse of thermal radiation that can be used for direct imaging. We demonstrate that stable Planck radiation pulses in the visible domain can repeatedly generated from discrete microscopic absorbers in a biological medium, with surprisingly high but non-desctructive temperatures jumps. A theoretical model will be discussed regarding the dynamics of heat transfer dynamics and the phase transition behavior of water at short space- and time-scales. This new microscopy can be used to image and detect pigmented cancer cells in tissues and blood samples with and outstanding sensitivity, and we will show the recent development of an ultrasensitive mid-infrared MCT-avalanche image detector.