Storage of hazardous substances in the laboratory-GHS

Based upon the labelling according the Globally Harmonized System (GHS).

For more information about the rules about labelling see: Labelling hazardous substances (WMS or GHS).

PGS 15 shows, as successor of the CPR 15-1, guidelines for the storage of packaged dangerous substances in the field of fire safety, occupational and environmental safety. The directive is used by the authorities in the provision of the Environmental Management Act permit

The PGS-15 is based on the transport legislation (European ADR).
The PGS-15 is particularly drawn for industrial warehouses and storage facilities. The packages here are the packages (and labels) used in the transport of dangerous substances.

The different classes in the PGS 15 are:

Class 2

Gas cylinders

Class 3

Flammable liquids

Class 4.1

Flammable solids, self-reactive substances and solid desensitized explosives

Class 4.2

Substances liable to spontaneous combustion

Class 4.3

Substances which, in contact with water, emit flammable gases

Class 5.1

Oxidizing substances

Class 5.2

Organic peroxides

Class 6.1

Toxic substances

Class 6.2, cat. 13 en 14

Infectious substances (UN 3291 and 3371)

Class 8

Corrosive substances

Class 9

Miscellaneous dangerous substances and articles, except genetically modified organisms

CMR stoffen

Carcinogenicity, germ cell mutagenicity and reproductive toxicity (category 1A en 1B)

Hazardous waste

 

Laboratories are characterized by the presence of many different types of substances, often in limited volumes. The packaging size is up to 2.5 liters for liquid bottles to 20 liters for barrels. The packaging label according GHS is used. Many bottles are for direct use in the laboratory. There are also containers for solid and liquid hazardous waste.

The storage of hazardous substances must be in accordance with the UT’s environmental permit (in accordance with PGS 15 guidelines or equivalent). General starting points for storage of hazardous substances are:

§

Toxic substances to be placed in a lockable (chemicals) cupboard;

§

Irritating substances in (aired) safety cupboards;

§

Acids and bases – separated – to be stored in drip-trays in aired cupboards;

§

Flammable substances to be placed in aired fire-resistant cupboards (compliant with NEN-EN-14470-1). Flammable substances in the refrigerator only if it is explosion-proof and it concerns small quantities (< 100 ml) that have been properly closed off. It needs to be properly indicated on the refrigerator whether it has been made explosion-proof. If the refrigerator has not been made explosion-proof, it needs to be clearly stated on the refrigerator that it is unsuitable for storing combustible substances. Further information on (aired) fire-resistance refrigerators can be obtained from the AMC-er.

§

Oxidising substances only in small quantities to be placed with other substances (e.g. concentrated acids) or in separate cupboards;

§

As to flammable liquids for direct use, a maximum of 1 litre per m2 surface area (up to a max. of 25 litres) may be present in the work space. The contents of the packaging may be up to a maximum of 2.5 litres, if more storage in a fire-proof cupboard is compulsory.

§

As to amounts for storage the following rules are in place:

-

loose cupboards: max. 150 litres or kg (30 minutes fire-resistant), max. 250 litres or kg (60-90 minutes fire-resistant),

-

structural cupboards: max. 250 litres or kg.

-

safes: max. 500 litres or kg (in buildings with floors only on ground floor), or 2500 kg (building without floors).

Explosive substances do not fall under the PGS-15. For each substance examine the safest method of storage, you may need to ask the AMC-er.

Substances reacting with one another releasing hazardous gasses or fumes or creating dangerous situations such as explosions or heat development, are to be stored in separate compartments. Consult the chemicals card book or the safety information sheet of each substance as to possible hazardous combinations of chemicals. It is for example not permitted to store (hypo) chlorite solutions with acids. Nitric acid may not be stored with formic acid, acetic acid, hydrochloric acid and formaldehyde solutions. See also annex 1: storage of chemicals, for combinations that are not to be stored together.

In a laboratory the backlog must be as small as possible but may be preferably not more than 1 kg or liters per m2 or equal to the stock needed for the consumption of one day or one batch. The calculation of 1 liter or kg per m2 is consistent with the standards for fire safety. Also from the health and safety legislation, the amount must be as low as possible and measures should be taken to avoid exposure in case of unwanted occurrences. Place therefore during work (flammable) liquids on the bench as much as possible in a drip. Store the bottles and barrels at the end of the day in the appropriate box (safety cupboard). Waste kegs in use for collecting hazardous waste are not subject to a backlog: it is primarily aqueous solutions. Full waste containers should be removed as soon as possible from the laboratory. If this is not possible storage takes place in a safety cupboard.


In the use and storage of hazardous substances in a laboratory the GHS classification is used and not the ADR classification..

The table on the following pages is for the different hazard classes, based on the hazardous label of a substance and the hazard statements, the method of storage in a laboratory displayed.

Hazard classes

Hazard label

H-statements

Storage

Physical hazards

 

- Explosives

- Self-reactive substances

- Organic peroxides

200

201

202

203

240

241

Ask AMC

Explosives (division 1.4)

204

Ask AMC

Flammable gasses, aerosols, liquids and solids

220

222

224

225

228

safety cupboard

Flammable aerosols and liquids

223

226

safety cupboard

- Pyrophoric solids and liquids.

- Self-reactive substances, mixtures

- Self-heating substances, mixtures

- Substances, mixtures which in contact with water emit flammable gases

- Organic peroxides

250

260

261

241

242

251

252

safety cupboard

- Oxidising gases, liquids and solids

270

271

272

safety cupboard

Gases under pressure

280

281

Safety cupboard for gases

Corrosive to metals

290

Acids and bases – separated –in drip-trays in aired cupboards

Health hazards

 

Acute toxicity

300

310

330

301

311

331

safety cupboard lockable (chemical) cupboard

- Germ cell mutagenicity

- Carcinogenicity

- Reproductive toxicy

- Specific Target Organ Toxicity (STOT), single and repeated exposure

- Respiratory sensitisation

- Aspiration hazard

(all category 1)

340

350

360

370

372

334

304

safety cupboard lockable (chemical) cupboard

- Germ cell mutagenicity

- Carcinogenicity

- Reproductive toxicy

- Specific Target Organ Toxicity (STOT), single and repeated exposure

- Respiratory sensitisation

- Aspiration hazard

(all category 2)

341

351

361

371

373

safety cupboard lockable (chemical) cupboard

Acute toxicity

302

312

332

safety cupboard lockable (chemical) cupboard

- Skin corrosion

- Serious eye damage

314

318

Acids and bases, separated, in drip-trays in aired cupboards

- Skin irritation

- Eye irritation

- Skin sensitisation

- STOT after single exposure

315

317

319

335

336

safety cupboard

Environmental hazards

 

Hazardous to the aquatic envrironment (acute, chronic)

400

410

411

Depending on the hazard label but always in drip-trays.

Annex 1 Storage of chemicals

The table below shows combinations of groups which:

§

May not be stored collectively ( - )

§

May possibly be stored in the same compartment ( +)

Whereby

A = oxidising substances

B = flammable liquids

C = flammable solids

D = (very) toxic substances

E = corrosive/caustic substances

 

A

B

C

D

E

A

 

-

-

-

-

B

-

 

+

-

-

C

-

+

 

+

-

D

-

-

+

 

-

E

-

-

-

-