MESA+ University of Twente
The BIOS Lab-on-a-chip group

The BIOS Lab-on-a-chip group

Project Description

Researches on silicon nanowire field-effect transistors (Si-NW FETs) have been very popular for over a decade. Due to the large surface-to-volume ratio, nanowires exhibit many interesting and unique physical characteristics, which endue nanowires with the special capability to be sensitive biosensors. For such applications, the gate material plays a crucial role on how well a biosensor performs. SiO2, a commonly used gate material for Si-NWs, can be simply formed by oxidation processes, however, there are several disadvantages for solution measurements:


Presents of intrinsic charge in buffer solution, which reduces surface charge sensitivity;


Device drift in buffer solution due to ion diffusion in SiO2;


Potential drop across the oxide gate.

These disadvantages become a big obstacle to the development of Si-NW biosensors. The goal of this project is to overcome these issues by applying advanced gate materials to improve both stability and sensitivity of Si-NW biosensors. We will perform real time protein/DNA detection with the advanced gate material. The sensing measurements will be carried out with the lab-on-a-chip (LOC) platform developed in BIOS group.

Left Top: HRSEM images of silicon nanowires; Left Bottom: Electrochemical measurement setup; Right: LOC/Si-NW biosensor platform.

Contact Information

Dr. Songyue Chen and Dr. Edwin Carlen

BIOS Lab on a Chip Group

MESA+ Institute for Nanotechnology

University of Twente