UTFacultiesTNWResearchDept BETNBPDutch Chaperone Day 2023
R Molenaar

Dutch Chaperone Day 2023

The 23rd Dutch Chaperone day will be hosted by the Nanobiophysics group of the University of Twente and will take place on Wednesday 19th of April 2023 in Enschede. This annual meeting brings together Dutch and international researchers interested in protein quality control, protein folding and protein folding diseases.

We encourage especially PhD students and young postdocs, to submit a title and short abstract of their work. Please also indicate if you prefer an oral presentation or a poster. From the submitted (short) abstracts, we will select people for an oral presentation at the meeting.  As always, there will be a poster session at the meeting.

  • Date:    Wednesday April 19, 2023 from 10.00-17.00 hours
  • Venue:  Technohal, lecture hall TL 1133 (Auditorium) on the campus of the University of Twente, Enschede
  • Registration is free of charge

Invited speakers

  • Dr. Christian Ottman, Molecular Cell and Structural Biology, Eindhoven University
  • Dr. Tessa Sinnige, Bijvoet Centre for Biomolecular Research, Utrecht University
  • Dr. Kasia Tych, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen
  • Program

    10:00 – 10:30  Arrival with Coffee & Tea

    10:30 – 11:05  Invited –  Kasia Tych, Groningen Biomolecular Sciences and Biotechnology Institute (GBB)  Title: Using single-molecule methods to observe Hsp90 in action.

    11:05 – 11:25  Eduardo De Mattos, Cellular Protein Chemistry, UU  Title: The second transmembrane domain is the aggregation sensitive element in CFTR.

    11:25 – 11:45  Gobert Heesink, Nanobiophysics, UT  Title: 14-3-3τ Interferes Early in α-Synuclein Aggregation

    11:45 – 12:05  Vasista Adupa, Micromechanics, RUG  Title: Resolving the structure-function relation of the molecular chaperone DNAJB6 and its role in polyQ aggregation using molecular dynamics simulations.                  

    12:05 – 13:30  Lunch and Poster Session

    13:30 –14:20  Keynote –  Christian Ottmann, Molecular Cell and Structural Biology, TUE  Title: Molecular Glues for 14-3-3 Protein-Protein Interactions.

    14:20 – 14:40  Júlia Aragonès Pedrola, Cellular Protein Chemistry, UU  Title: Fibril paint to determine amyloid size.

    14:40 – 15:00  Wojciech Lipinski, Coacervates and Soft Interfaces, RU  Title: Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein.

    15:00 – 15:20  Tegan Otto, Cellular Biochemistry, ERIBA, UMCG  Title: Nucleoporin Nsp1 guards stability of intrinsically disordered proteins.

    15:20 – 15:50  Coffee Break

    15:50 – 16:25  Invited –  Tessa Sinnige, Membrane Biochemistry and Biophysics, UU  Title: The biophysics of protein aggregation studied in a multicellular animal model.

    16:25 – 16:45  Irene Van Dijken, Princess Maxima Center and Oncode Institute, Utrecht  Title: Chaperonin TRIC/CCT modulates the efficacy of endoplasmic reticulum-associated degeneration.

    16:45 – 17:05  Mario Mauthe, Molecular Cell Biology, UMCG  Title: Chaperone-mediated fragmentation of aggregates is essential for autophagic turnover.

    17:05 –17:15  Closing remarks

    17:15 – 17:45  Drinks & Bites

We hope to see many of you in Enschede in April!

Mireille Claessens and Christian Blum

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