NeuroChip - Nano-electrodes for electrical recordings in human brain cells Techniques to record electrical activity from brain cells are essential for brain research and the screening of potential new drugs against bran disease. We want to explore a new approach to electrically record many single neurons in parallel, with high-resolution, using nano-electrodes on a chip. The main challenge is to integrate the electrodes into the cellular membrane to create a GigaOhm "seal" to prevent leakage of electrical current from the cell.
Development of a sensor for drug testing The goal of this project is to develop a microfluidic sensing system to capture target molecules are produced as a result of metabolized medicines in the body. The project consists of several steps including, investigation of the drug metabolites and sensing molecules giving colorimetric reactions upon exposure, integration of the sensing molecules into the microfluidic system, improvement of the system for optimal results.
Development of a microfluidic chip for anti-counterfeiting in diagnosis The overall goal of this project is to develop a microfluidic system for static or dynamic security code generation using hydrogels and microchannels. This project consists of several steps including, identification of e.g. colorimetric reactions, swelling properties, etc. to be used as the main working mechanism, design, and optimization of a hydrogel-integrated microfluidic platform. Several model studies including high-content optical codes, embedded bar-codes, polymer microtaggants, could be considered as a starting point to boost creativity in this project.
Noble metal patterns by controlled dewetting on 3D curved surfaces Solid-state metal dewetting is a process that occurs at higher temperatures, and is one of the causes for catalyst particle agglomeration. The assignment focuses on the construction of various 3D test structures of sizes ranging from nanometers to micrometers, with the goal of studying the effect of local 3D surface curvature on this dewetting process. The experimental work involves silicon microfabrication and thin film deposition, with subsequent metal coating and annealing of the structure.