During, for example, hart surgeries, an artificial lung machine is used to oxygenate the patients’ blood. During this step, CO2 must be removed from the blood and O2 will be introduced. This is often done by poly(dimethyl siloxane) (PDMS) membranes. However, protein adsorption on these PDMS surfaces can cause an immune reaction, and therefore clogging of the blood will occur.
Protein adsorption and clogging can be prevented by coating the PDMS with a thin layer of cells. A surface with primary amine groups potentially allows for the adhesion of cells to the PDMS surface.
During this assignment, the student will explore possible pathways on how to functionalize the PDMS scaffold with primary amine groups. After functionalization of the PDMS, the resulting materials will be characterized with, FTIR, SEM and AFM.
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