Ma B. - Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

Bin Ma, Jeroen Leijten, Ling Wu, Michelle Kip, Clemens A. van Blitterswijk, Janine N. Post, Marcel Karperien

Osteoarthritis and Cartilage 2013



When primary chondrocytes are cultured in monolayer, they undergo dedifferentiation during which they lose their phenotype and their capacity to form cartilage. Dedifferentiation is an obstacle for cell therapy for cartilage degeneration. In this study, we aimed to systemically evaluate the changes in gene expression during dedifferentiation of human articular chondrocytes to identify underlying mechanisms.