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2024
Synergistic effect of Hypoxic Conditioning and Cell-Tethering Colloidal Gels enhanced Productivity of MSC Paracrine Factors and Accelerated Vessel Regeneration (2024)Advanced materials. Article 2408488 (E-pub ahead of print/First online). Lee, M. C., Lee, J. S., Kim, S., Jamaiyar, A., Wu, W., Gonzalez, M. L., Durán, T. C. A., Madrigal-Salazar, A. D., Bassous, N., Carvalho, V., Choi, C., Kim, D. S., Seo, J. W., Rodrigues, N., Teixeira, S. F. C. F., Alkhateeb, A. F., Soto, J. A. L., Hussain, M. A., Leijten, J., … Shin, S. R.https://doi.org/10.1002/adma.202408488Hyaluronic acid and dextran hydrogels for tissue engineering applications (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Banigo, A. T.https://doi.org/10.3990/1.9789036562218Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis (2024)Journal of cellular physiology. Article e31443 (E-pub ahead of print/First online). Govindaraj, K., Kannan, S., Coutinho de Almeida, R., Jansen Klomp, L., Karperien, M., Meulenbelt, I. & Post, J. N.https://doi.org/10.1002/jcp.31443Coaxial Bioprinting of Enzymatically Crosslinkable Hyaluronic Acid-Tyramine Bioinks for Tissue Regeneration (2024)Polymers, 16(17). Article 2470. Banigo, A. T., Nauta, L., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/polym16172470Dextran-tryamine hydrogel maintains position and integrity under simulated loading in a human cadaver knee model (2024)Osteoarthritis and Cartilage Open, 6(3). Article 100492. van der Weiden, G. S., Mastbergen, S. C., Both, S. K., Karperien, M., Lafeber, F. P., van Egmond, N. & Custers, R. J. H.https://doi.org/10.1016/j.ocarto.2024.100492Bioactive Hydrogels Based on Tyramine and Maleimide Functionalized Dextran for Tissue Engineering Applications (2024)Gels, 10(9). Article 566. Zhong, L., Banigo, A. T., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/gels10090566Injectable Self-Oxygenating Cardio-Protective and Tissue Adhesive Silk-Based Hydrogel for Alleviating Ischemia After Mi Injury (2024)Small, 20(32). Article 2312261. Hassan, S., Rezaei, Z., Luna, E., Yilmaz-Aykut, D., Lee, M. C., Perea, A. M., Jamaiyar, A., Bassous, N., Hirano, M., Tourk, F. M., Choi, C., Becker, M., Yazdi, I., Fan, K., Avila-Ramirez, A. E., Ge, D., Abdi, R., Fisch, S., Leijten, J., … Shin, S. R.https://doi.org/10.1002/smll.202312261Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels (2024)Small (E-pub ahead of print/First online). Husch, J. F. A., Araújo-Gomes, N., Willemen, N. G. A., Cofiño-Fabrés, C., van Creij, N., Passier, R., Leijten, J. & van den Beucken, J. J. J. P.https://doi.org/10.1002/smll.202403272Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (2024)Advanced materials, 36(28). Article 2308949. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J.https://doi.org/10.1002/adma.202308949Engineering Synthetic Erythrocytes as Next-Generation Blood Substitutes (2024)Advanced functional materials, 34(28). Article 2315879. Gomes, F. L., Jeong, S. H., Shin, S. R., Leijten, J. & Jonkheijm, P.https://doi.org/10.1002/adfm.202315879Bioinspired crosslinking reactions occurring under physiological conditions for the synthesis of hydrogels for cell culture (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Jin, M.https://doi.org/10.3990/1.9789036561051An introduction to injectable hydrogels (2024)Journal of materials chemistry. B: materials for biology and medicine, 12(23), 5571-5572. Paez, J. I. & Lim, K. S.https://doi.org/10.1039/d4tb90085eTowards single-cell bioprinting: micropatterning tools for organ-on-chip development (2024)Trends in biotechnology, 42(6), 739-759. Bosmans, C., Ginés Rodriguez, N., Karperien, M., Malda, J., Moreira Teixeira, L., Levato, R. & Leijten, J.https://doi.org/10.1016/j.tibtech.2023.11.014An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs (2024)Bio-Design and Manufacturing, 7(3), 240-261. Jeong, S. H., Hiemstra, J., Blokzijl, P. V., Damian-Ferrara, R., dos Santos, D. M., da Fonseca, J. H. L., Kang, M. H., Kim, J., Yilmaz-Aykut, D., Cham-Pérez, M. L. L., Leijten, J. & Shin, S. R.https://doi.org/10.1007/s42242-024-00281-7Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology (2024)Advanced science, 11(11). Article 2306722. Govindaraj, K., Meteling, M., van Rooij, J., Becker, M., van Wijnen, A. J., van den Beucken, J. J. J. P., Ramos, Y. F. M., van Meurs, J., Post, J. N. & Leijten, J.https://doi.org/10.1002/advs.202306722Health-related quality of life in early onset scoliosis patients treated with the spring distraction system: what to expect in the first 2 years after surgery (2024)Spine Deformity, 12(2), 489-499. Lemans, J. V. C., Top, A., Tabeling, C. S., Scholten, E. P., Stempels, H. W., Schlösser, T. P. C., Castelein, R. M. & Kruyt, M. C.https://doi.org/10.1007/s43390-023-00777-9Scalable production of 3D microtissues using novel microfluidic technologies (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Loo, S. R.https://doi.org/10.3990/1.9789464960372Gelatin-tyramine addition and low hydrogel density improves cell attachment, migration, and metabolic activity in vitro and tissue response in vivo in enzymatically crosslinkable dextran-hyaluronic acid hydrogels (2024)International journal of biological macromolecules, 259. Article 128843. Hendriks, J., Zoetebier, B., Larrea, C. S., Le, N. X. T., Saris, D. B. F. & Karperien, M.https://doi.org/10.1016/j.ijbiomac.2023.128843Enzyme Responsive Delivery of Engineered Antibody Fragments (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Zhong, L.https://doi.org/10.3990/1.9789036559706
2023
Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules (2023)Nature communications, 14. Article 6685. van Loo, S. R., ten Den, S. A., Araújo-Gomes, N., de Jong, V., Snabel, R., Schot, M. R., Rivera Arbelaez, J. M., Veenstra, G. J., Passier, R., Kamperman, T. & Leijten, J.https://doi.org/10.1038/s41467-023-42297-0Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Spoelstra, L. R., Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M., Karperien, M., Segerink, L. & Le Gac, S.Single-Step Biofabrication of In Situ Spheroid-Forming Compartmentalized Hydrogel for Clinical-Sized Cartilage Tissue Formation (2023)Advanced healthcare materials, 12(27). Article 2300095. van Loo, B., Schot, M., Gurian, M., Kamperman, T. & Leijten, J.https://doi.org/10.1002/adhm.202300095The use of peptides, aptamers, and variable domains of heavy chain only antibodies in tissue engineering and regenerative medicine (2023)Acta biomaterialia, 170, 1-14. Koerselman, M., Morshuis, L. C. M. & Karperien, M.https://doi.org/10.1016/j.actbio.2023.07.045Bioluminescence imaging on-chip platforms for non-invasive high-content bioimaging (2023)Biosensors & bioelectronics, 237. Article 115510. Araújo-Gomes, N., Zambito, G., Johnbosco, C., Calejo, I., Leijten, J., Löwik, C., Karperien, M., Mezzanotte, L. & Teixeira, L. M.https://doi.org/10.1016/j.bios.2023.115510Microencapsulated stem cells reduce cartilage damage in a material dependent manner following minimally invasive intra-articular injection in an OA rat model (2023)Materials Today Bio, 22. Article 100791. Johnbosco, C., Karbaat, L., Korthagen, N. M., Warmink, K., Koerselman, M., Coeleveld, K., Becker, M., van Loo, B., Zoetebier, B., Both, S., Weinans, H., Karperien, M. & Leijten, J.https://doi.org/10.1016/j.mtbio.2023.100791Self-oxygenation of engineered living tissues orchestrates osteogenic commitment of mesenchymal stem cells (2023)Biomaterials, 300. Article 122179. Hassan, S., Wang, T., Shi, K., Huang, Y., Urbina Lopez, M. E., Gan, K., Chen, M., Willemen, N., Kalam, H., Luna-Ceron, E., Cecen, B., Elbait, G. D., Li, J., Garcia-Rivera, L. E., Gurian, M., Banday, M. M., Yang, K., Lee, M. C., Zhuang, W., … Ryon Shin, S.https://doi.org/10.1016/j.biomaterials.2023.122179Microfluidic Generation of Thin-Shelled Polyethylene Glycol-Tyramine Microgels for Non-Invasive Delivery of Immunoprotected β-Cells (2023)Advanced healthcare materials. Article 2301552 (E-pub ahead of print/First online). Araújo-Gomes, N., Zoetebier-Liszka, B., van Loo, B., Becker, M., Nijhuis, S., Smink, A. M., de Haan, B. J., de Vos, P., Karperien, M. & Leijten, J.https://doi.org/10.1002/adhm.202301552Choice of Protein, Not Its Amyloid-Fold, Determines the Success of Amyloid-Based Scaffolds for Cartilage Tissue Regeneration (2023)ACS Omega, 8(27), 24198-24209. Dalen, M. C. E. v., Karperien, M., Claessens, M. M. A. E. & Post, J. N.https://doi.org/10.1021/acsomega.3c00151Effect of Autologous Conditioned Plasma Injections in Patients With Knee Osteoarthritis (2023)Orthopaedic Journal of Sports Medicine, 11(7). Korpershoek, J. V., Vonk, L. A., Filardo, G., Kester, E. C., van Egmond, N., Saris, D. B. F. & Custers, R. J. H.https://doi.org/10.1177/23259671231184848A Modular Platform for Cytocompatible Hydrogels with Tailored Mechanical Properties Based on Monolithic Matrices and Particulate Building Blocks (2023)Biomacromolecules, 24(6), 2755–2765. Andrée, L., Bertsch, P., Wang, R., Becker, M., Leijten, J., Fischer, P., Yang, F. & Leeuwenburgh, S. C. G.https://doi.org/10.1021/acs.biomac.3c00177Altered intracellular molecular crowding plays a key role in osteoarthritis pathology (2023)[Contribution to conference › Poster] 47th FEBS Congress 2023. Govindaraj, K., Meteling, M. A. W. & Leijten, J.Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli-Responsive Cell-Adhesive Micromaterials (2023)Advanced science, 10(10). Article 2205487. Kamperman, T., Willemen, N. G. A., Kelder, C., Koerselman, M., Becker, M., Lins, L., Johnbosco, C., Karperien, M. & Leijten, J.https://doi.org/10.1002/advs.202205487Spatial control of self-organizing vascular networks with programmable aptamer-tethered growth factor photopatterning (2023)Materials Today Bio, 19. Article 100551. Rana, D., Padmanaban, P., Becker, M., Stein, F., Leijten, J., Koopman, B. & Rouwkema, J.https://doi.org/10.1016/j.mtbio.2023.100551Mapping RUNX2 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells (2023)[Working paper › Preprint]. bioRxiv. Govindaraj, K., Kannan, S., Karperien, M. & Post, J. N.https://doi.org/10.1101/2023.03.30.534618High-Throughput Fabrication of Size-Controlled Pickering Emulsions, Colloidosomes, and Air-Coated Particles via Clog-Free Jetting of Suspensions (2023)Advanced materials, 35(13). Article 2208894. Jiang, J., Poortinga, A. T., Liao, Y., Kamperman, T., Venner, C. H. & Visser, C. W.https://doi.org/10.1002/adma.202208894Aqueous Two-Phase Enabled Low Viscosity 3D (LoV3D) Bioprinting of Living Matter (2023)Advanced science, 10(8). Article 2204609. Becker, M., Gurian, M., Schot, M. & Leijten, J.https://doi.org/10.1002/advs.202204609Programmable bio-ionic liquid functionalized hydrogels for in situ 3D bioprinting of electronics at the tissue interface (2023)Materials Today Advances, 17. Article 100352. Krishnadoss, V., Kanjilal, B., Masoumi, A., Banerjee, A., Dehzangi, I., Pezhouman, A., Ardehali, R., Martins-Green, M., Leijten, J. & Noshadi, I.https://doi.org/10.1016/j.mtadv.2023.100352Aggregation and Gelation Behavior of Stereocomplexed Four-Arm PLA-PEG Copolymers Containing Neutral or Cationic Linkers (2023)International journal of molecular sciences, 24(4). Article 3327. Signori, F., Wennink, J. W. H., Bronco, S., Feijen, J., Karperien, M., Bizzarri, R. & Dijkstra, P. J.https://doi.org/10.3390/ijms24043327Chitosan and carboxymethyl cellulose-based 3D multifunctional bioactive hydrogels loaded with nano-curcumin for synergistic diabetic wound repair (2023)International journal of biological macromolecules, 227, 1203-1220. Shah, S. A., Sohail, M., Karperien, M., Johnbosco, C., Mahmood, A. & Kousar, M.https://doi.org/10.1016/j.ijbiomac.2022.11.307Enzymatic co-crosslinking of star-shaped poly(ethylene glycol) tyramine and hyaluronic acid tyramine conjugates provides elastic biocompatible and biodegradable hydrogels (2023)Bioactive Materials, 20, 53-63. Wang, R., Huang, X., Zoetebier, B., Dijkstra, P. J. & Karperien, M.https://doi.org/10.1016/j.bioactmat.2022.05.020Gelation Kinetics and Mechanical Properties of Thiol-Tetrazole Methylsulfone Hydrogels Designed for Cell Encapsulation (2023)Macromolecular bioscience, 23(2). Article 2200419. de Miguel-Jiménez, A., Ebeling, B., Paez, J. I., Fink-Straube, C., Pearson, S. & del Campo, A.https://doi.org/10.1002/mabi.202200419Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] 32nd NBTE Annual Meeting 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Improving interfacial adhesion of hydrogel matrices to PDMS-based microfluidic platforms (2023)[Contribution to conference › Poster] TechMed Research Day 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Preclinical model for lumbar interbody fusion in small ruminants: Rationale and guideline (2023)Journal of orthopaedic translation, 38, 167-174. Duits, A., Salvatori, D., Schouten, J., van Urk, P., Gaalen, S. v., Ottink, K., Öner, C. & Kruyt, M.https://doi.org/10.1016/j.jot.2022.10.006Scalable fabrication, compartmentalization and applications of living microtissues (2023)Bioactive Materials, 19, 392-405. Schot, M., Araújo-Gomes, N., van Loo, B., Kamperman, T. & Leijten, J.https://doi.org/10.1016/j.bioactmat.2022.04.005
2022
Kinetic characterization of SPR-based biomarker assays enables quality control, calibration free measurements and robust optimization for clinical application (2022)Analytical biochemistry, 658. Article 114918. Hendriks, J., Schasfoort, R. B. M., Huskens, J., Saris, D. B. F. & Karperien, M.https://doi.org/10.1016/j.ab.2022.114918Use of Allogeneic Mesenchymal Signaling Cells (MSCs) to Augment Cartilage Repair (2022)Operative Techniques in Sports Medicine, 30(4). Article 150962. Saris, T. F. F., de Windt, T. S., Custers, R. J. H. & Saris, D. B. F.https://doi.org/10.1016/j.otsm.2022.150962Tunable and Compartmentalized Multimaterial Bioprinting for Complex Living Tissue Constructs (2022)ACS applied materials & interfaces, 14(46), 51602-51618. Hassan, S., Gomez-Reyes, E., Enciso-Martinez, E., Shi, K., Campos, J. G., Soria, O. Y. P., Luna-Cerón, E., Lee, M. C., Garcia-Reyes, I., Steakelum, J., Jeelani, H., García-Rivera, L. E., Cho, M., Cortes, S. S., Kamperman, T., Wang, H., Leijten, J., Fiondella, L. & Shin, S. R.https://doi.org/10.1021/acsami.2c12585Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules (2022)Cells, 11(22). Article 3657. van Tienderen, G. S., Willemse, J., van Loo, B., van Hengel, E. V. A., de Jonge, J., van der Laan, L. J. W., Leijten, J. & Verstegen, M. M. A.https://doi.org/10.3390/cells11223657Small antibodies with a big opportunity: The variable domain of the heavy chain only antibody and its potential as disease modifying osteoarthritic drug (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Koerselman, M.https://doi.org/10.3990/1.9789036554404Hybrid extracellular vesicles-liposome incorporated advanced bioink to deliver microRNA (2022)Biofabrication, 14(4). Article 045008. Elkhoury, K., Chen, M., Koçak, P., Enciso-Martínez, E., Bassous, N. J., Lee, M. C., Byambaa, B., Rezaei, Z., Li, Y., Ubina López, M. E., Gurian, M., Sobahi, N., Hussain, M. A., Sanchez-Gonzalez, L., Leijten, J., Hassan, S., Arab-Tehrany, E., Ward, J. E. & Ryon Shin, S.https://doi.org/10.1088/1758-5090/ac8621Injectable Cell-Laden Polysaccharide Hydrogels: In Vivo Evaluation of Cartilage Regeneration (2022)Polymers, 14(20). Article 4292. Fu, Y., Both, S. K., Plass, J. R. M., Dijkstra, P. J., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/polym14204292Current strategies for ligand bioconjugation to poly(acrylamide) gels for 2D cell culture: Balancing chemo-selectivity, biofunctionality, and user-friendliness (2022)Frontiers in Chemistry, 10. Article 1012443. Wolfel, A., Jin, M. & Paez, J. I.https://doi.org/10.3389/fchem.2022.1012443Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs (2022)Advanced science, 9(25). Article 2201392. Kajtez, J., Wesseler, M. F., Birtele, M., Khorasgani, F. R., Rylander Ottosson, D., Heiskanen, A., Kamperman, T., Leijten, J., Martínez-Serrano, A., Larsen, N. B., Angelini, T. E., Parmar, M., Lind, J. U. & Emnéus, J.https://doi.org/10.1002/advs.202201392Redox-triggerable firefly luciferin-bioinspired hydrogels as injectable and cell-encapsulating matrices (2022)Polymer chemistry, 13(35), 5116-5126. Jin, M., Gläser, A. & Paez, J. I.https://doi.org/10.1039/d2py00481jEnzyme-Mediated Alleviation of Peroxide Toxicity in Self-Oxygenating Biomaterials (2022)Advanced healthcare materials, 11(13). Article 2102697. Willemen, N. G. A., Hassan, S., Gurian, M., Jasso-Salazar, M. F., Fan, K., Wang, H., Becker, M., Allijn, I. E., Bal-Öztürk, A., Leijten, J. & Ryon Shin, S.https://doi.org/10.1002/adhm.202102697Simulating differentiation from iPS cells to chondrocytes (2022)[Contribution to conference › Poster] Bioinformatics & Systems Biology Conference, BioSB 2022. Jansen Klomp, L., Coutinho de Almeida, R., Meulenbelt, I., Post, J. N. & Meijer, H. G. E.Implementing Computational Modeling in Tissue Engineering: Where Disciplines Meet (2022)Tissue engineering. Part A, 28(11-12), 542-554. Post, J. N., Loerakker, S., Merks, R. M. H. & Carlier, A.https://doi.org/10.1089/ten.tea.2021.0215Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects (2022)Tissue engineering. Part A, 28(11-12), 478-499. Zoetebier, B., Schmitz, T. C., Ito, K., Karperien, M., Tryfonidou, M. A. & Paez, J. I.https://doi.org/10.1089/ten.tea.2021.02263D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes (2022)ACS biomaterials science & engineering, 8(6), 2684-2699. Baptista, D., Moreira Teixeira, L., Barata, D., Tahmasebi Birgani, Z., King, J., van Riet, S., Pasman, T., Poot, A. A., Stamatialis, D., Rottier, R. J., Hiemstra, P. S., Carlier, A., van Blitterswijk, C., Habibović, P., Giselbrecht, S. & Truckenmüller, R.https://doi.org/10.1021/acsbiomaterials.1c01463Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip (2022)Lab on a chip, 22(9), 1815-1828. Paggi, C. A., Hendriks, J., Karperien, M. & Gac, S. L.https://doi.org/10.1039/D1LC01069GMicrofluidic fabrication of lipid nanoparticles for the delivery of nucleic acids (2022)Advanced drug delivery reviews, 184. Article 114197. Prakash, G., Shokr, A., Willemen, N., Bashir, S. M., Ryon Shin, S. & Hassan, S.https://doi.org/10.1016/j.addr.2022.114197One-Step Fabrication of Porous Membrane-Based Scaffolds by Air-Water Interfacial Phase Separation: Opportunities for Engineered Tissues (2022)Membranes, 12(5). Article 453. Allijn, I., du Preez, N., Tasior, M., Bansal, R. & Stamatialis, D.https://doi.org/10.3390/membranes12050453High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease Severity (2022)Frontiers in Immunology, 13. Article 867716. Hendriks, J., Schasfoort, R., Koerselman, M., Dannenberg, M., Cornet, A. D., Beishuizen, A., van der Palen, J., Krabbe, J., Mulder, A. H. L. & Karperien, M.https://doi.org/10.3389/fimmu.2022.867716Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis (2022)Carbohydrate polymers, 281. Article 118923. Allawadhi, P., Singh, V., Govindaraj, K., Khurana, I., Sarode, L. P., Navik, U., Banothu, A. K., Weiskirchen, R., Bharani, K. K. & Khurana, A.https://doi.org/10.1016/j.carbpol.2021.118923Intra-articular drug depots for controlled release of heavy chain only antibodies blocking joint inflammation (2022)Osteoarthritis and cartilage, 29(suppl. 1), S12-S13. Koerselman, M., Warmink, K., Korthagen, N. M., van Midwoud, P. M., Verrips, T., Weinans, H. & Karperien, M.https://doi.org/10.1016/j.joca.2021.02.032Joint-on-chip platforms: entering a new era of in vitro models for arthritis (2022)Nature reviews rheumatology, 18, 217-231. Paggi, C. A., Moreira Teixeira, L., le Gac, S. & Karperien, M.https://doi.org/10.1038/s41584-021-00736-6Osmolarity-Induced altered intracellular molecular crowding drives osteoarthritis pathology (2022)Osteoarthritis and cartilage, 30(Suppl. 1), S24-S25. Govindaraj, K., Meteling, M., Becker, M., Post, J. & Leijten, J.https://doi.org/10.1016/j.joca.2022.02.021Developing a joint-on-chip platform: A multi-organ-on-chip model to mimic healthy and diseased conditions of the synovial joints (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Paggi, C. A.https://doi.org/10.3990/1.9789036553261Human meniscus allograft augmentation by allogeneic mesenchymal stromal/stem cell injections (2022)Journal of orthopaedic research, 40(3), 712-726. Struijk, C., Van Genechten, W., Verdonk, P., Krych, A. J., Dietz, A. B., van Wijnen, A. J. & Saris, D. B. F.https://doi.org/10.1002/jor.25074Advancing Tumor Microenvironment Research by Combining Organs-on-Chips and Biosensors (2022)In Microfluidics and Biosensors in Cancer Research: Applications in Cancer Modeling and Theranostics (pp. 171-203) (Advances in Experimental Medicine and Biology; Vol. 1379). Springer. Calejo, I., Heinrich, M. 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2021
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A. & Karperien, M.https://doi.org/10.1021/acs.analchem.5b00114Synovial fluid concentration of Gremlin1 but not frizzled-related protein is increased in patients after acute knee injury (2015)[Contribution to conference › Abstract] 2015 OARSI World Congress on Osteoarthritis. Zhong, L., Leijten, J. C. H., Post, J. N., Larsson, S., Karperien, H. B. J. & Struglics, A.Injectable hydrogel for cartilage repair (2015)[Contribution to conference › Abstract] Health Valley, Nijmegen, Netherlands. Both, S. K., Wang, R., Dijkstra, P. J. & Karperien, H. B. J.Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets (2015)Journal of cellular and molecular medicine, 19(8), 1836-1846. Hilderink, J., Spijker, S., Carlotti, F., Lange, L., Engelse, M., van Blitterswijk, C., de Koning, E., Karperien, M. & van Apeldoorn, A. A.https://doi.org/10.1111/jcmm.12555In vitro development of donated frozen-thawed human embryos in a prototype static microfluidic device: a randomized controlled trial (2015)Fertility and sterility, 103(3), 680-686. Kieslinger, D. C., Hao, Z., Vergouw, C. G., Kostelijk, E. H., Lambalk, C. B. & le Gac, S.https://doi.org/10.1016/j.fertnstert.2014.12.089The influence of process parameters on the properties of electrospun PLLA yarns studied by the response surface methodology (2015)Journal of applied polymer science, 132(5). Article 41388. Maleki, H., Gharehaghaji, A. A., Criscenti, G., Moroni, L. & Dijkstra, P. J.https://doi.org/10.1002/app.41388Osteogenic capacity of human BM-MSCs, AT-MSCs and their co-cultures using HUVECs in FBS and PL supplemented media. (2015)Journal of tissue engineering and regenerative medicine, 9(7), 779-788. Ma, K., van den Beucken, J. J., Both, S. K., Prins, H. J., Helder, M. N., Yang, F. & Jansen, J. A.https://doi.org/10.1002/term.1704Poly(amido amine)-based multilayered thin films on 2D and 3D supports for surface-mediated cell transfection (2015)Journal of controlled release, 205, 181-189. Hujaya, S. D., Marchioli, G., Roelofs, K., van Apeldoorn, A. A., Moroni, L., Karperien, M., Paulusse, J. M. J. & Engbersen, J. F. J.https://doi.org/10.1016/j.jconrel.2015.01.034Novel biomedical applications of supported lipid bilayers (2015)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Weerd, J.https://doi.org/10.3990/1.9789036538268Quantifying cell adhesion through impingement of a controlled microjet (2015)Biophysical journal, 108(1), 23-31. Visser, C. W., Gielen, M. V., Hao, Z., le Gac, S., Lohse, D. & Sun, C.https://doi.org/10.1016/j.bpj.2014.10.071Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study (2015)Osteoarthritis and cartilage, 23(1), 143-150. de Windt, T. S., Vonk, L. A., Buskermolen, J. K., Visser, J., Karperien, M., Bleys, R. L. A. W., Dhert, W. J. A. & Saris, D. B. F.https://doi.org/10.1016/j.joca.2014.09.016Cartilage Regeneration in the Head and Neck Area: Combination of Ear or Nasal Chondrocytes and Mesenchymal Stem Cells Improves Cartilage Production (2015)Plastic and reconstructive surgery, 136(6), 762e-774e. Pleumeekers, M. M., Nimeskern, L., Koevoet, W. L. M., Karperien, M., Stok, K. S. & van Osch, G. J. V. M.https://doi.org/10.1097/PRS.0000000000001812Designer Peptide (2015)[Patent › Patent] (In preparation). Post, J. N., Karperien, H. B. J. & Scholma, J.Engineering Cartilage Tissue by Pellet Coculture of Chondrocytes and Mesenchymal Stromal Cells (2015)In Osteoporosis and Osteoarthritis (pp. 31-41) (Methods in molecular biology; Vol. 1226). Springer. Wu, L., Post, J. N. & Karperien, H. B. J.https://doi.org/10.1007/978-1-4939-1619-1_4In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction (2015)PLoS ONE, 10(12), -. Article e0145240. Steins, A., Dik, P., Müller, W. H., Vervoort, S. J., Reimers, K., Kubhier, J. W., Vogt, P. M., van Apeldoorn, A. A., Coffer, P. J. & Schepers, K.https://doi.org/10.1371/journal.pone.0145240Optimizing cell viability in droplet-based cell deposition (2015)Scientific reports, 5. Article 11304. Hendriks, J., Visser, C. W., Henke, S. J., Leijten, J. C. H., Saris, D. B. F., Sun, C., Lohse, D. & Karperien, H. B. J.https://doi.org/10.1038/srep11304Osteoarthritis treatment using autologous conditioned serum after placebo: Patient considerations and clinical response in a non-randomized case series (2015)Acta orthopaedica, 86(1), 114-118. Rutgers, M., Creemers, L. B., Yang, K. G. A., Raijmakers, N. J. H., Dhert, W. J. A. & Saris, D. B. F.https://doi.org/10.3109/17453674.2014.950467Pain following primary total knee replacement: Causes, diagnosis and treatment (2015)Nederlands tijdschrift voor geneeskunde, 159(40), -. Article A8445. van Geene, A. R., Saris, D. B. F. & Custers, R. J. H.https://www.ntvg.nl/artikelen/pijn-na-primaire-totale-knieprothese/artikelinfoPhoto-switchable distributors of light based on self-assembled monodisperse chiral nematic microspheres (2015)In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 233-235). The Chemical and Biological Microsystems Society. Asshoff, S. J., Lancia, F., Sukas, S., Blondé, J. B., Yamaguchi, T., Hommersom, C. A., Le Gac, S. & Katsonis, N.Photoacoustic imaging: Cells make themselves heard (2015)Nature photonics, 9, 216-218. Manohar, S., van Apeldoorn, A. A. & Steenbergen, W.https://doi.org/10.1038/nphoton.2015.46Photoresponsive Cucurbit[8]uril-Mediated Adhesion of Bacteria on Supported Lipid Bilayers (2015)Small, 11(46), 6187-6196. Sankaran, S., van Weerd, J., Voskuhl, J., Karperien, H. B. J. & Jonkheijm, P.https://doi.org/10.1002/smll.201502471
2014
On-Chip Electrophoresis in Supported Lipid Bilayer Membranes Achieved Using Low Potentials (2014)Journal of the American Chemical Society, 136(1), 100-103. van Weerd, J., Krabbenborg, S., Eijkel, J. C. T., Karperien, H. B. J., Huskens, J. & Jonkheijm, P.https://doi.org/10.1021/ja411287uDroplet microfluidics for the encapsulation of beta-cells in microgels of natural polysaccharides conjugates (2014)[Contribution to conference › Abstract] 23rd NBTE Annual Meeting 2014. Henke, S. J., Leijten, J. C. H., Kamperman, T., Wang, R., van den Berg, A., Dijkstra, P. J., van Apeldoorn, A. A. & Karperien, H. B. J.Hydrogels By Supramolecular Crosslinking Of Terpyridine End Group Functionalized 8-arm Poly(Ethylene Glycol) (2014)[Contribution to conference › Poster] 23rd NBTE Annual Meeting 2014. Wang, R., Dijkstra, P. J. & Karperien, H. B. J.Primary Chemical Sequence Ultimately Determines Crystal Thickness in Segmented All-Aliphatic Copolymers (2014)Macromolecules, 47(22), 7890-7899. Odarchenko, Y. I., Anokhin, D. V., Doblas, D., Rosenthal, M., Hernandez, J. J., Vidal, L., Sijbrandi, N. J., Kimenai, A. J., Mes, E. P. C., Broos, R., Bar, G., Dijkstra, P. J., Feijen, J., Soloviev, M. & Ivanov, D. A.https://doi.org/10.1021/ma501545bHydrogels By Supramolecular Crosslinking Of Terpyridine End Group Functionalized 8-arm Poly(Ethylene Glycol) (2014)[Contribution to conference › Abstract] NIRM 2014, Rotterdam, 29-30 October 2014. Wang, R., Dijkstra, P. J. & Karperien, H. B. J.Hydrogels By SupramolecularCrosslinking Of Terpyridine End Group Functionalized 8-Arm Poly(Ethylene Glycol) (2014)[Contribution to conference › Poster] NIRM 2014, Rotterdam, Netherlands. Wang, R., Dijkstra, P. J. & Karperien, H. B. J.Microfluidic production of tissue engineered islets of Langerhans: microgel functionalization using biomimetic elements (2014)[Contribution to conference › Abstract] New Frontiers In Regenerative Medicine Symposium 2014, Nijmegen. Henke, S. J., Leijten, J. C. H., van den Berg, A., Dijkstra, P. J., van Apeldoorn, A. A. & Karperien, H. B. J.Boosting angiogenesis and functional vascularization in injectable dextran-hyaluronic acid hydrogels by endothelial-like mesenchymal stromal cells (2014)Tissue engineering. Part A, 20(3-4), 819-829. Janeczek Portalska, K., Moreira Teixeira, L., Leijten, J. C. H., Jin, R., van Blitterswijk, C., de Boer, J. & Karperien, M.https://doi.org/10.1089/ten.TEA.2013.0280Glucose Gradients Influence Zonal Matrix Deposition in 3D Cartilage Constructs (2014)Tissue engineering. Part A, 20(23-24), 3270-3278. Spitters, T., Mota, C. M. D., Uzoechi, S. C., Slowinska, B., Martens, D. E., Moroni, L. & Karperien, H. B. J.https://doi.org/10.1089/ten.tea.2014.0059Method for making a polymer, a polymer article, a biodevice, and cyclic carbonate (2014)[Patent › Patent]. Zhong, Z., Meng, F., Wang, R. & Feijen, J.Single domain antibodies in tissue engineering (2014)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Rodrigues, E. D.https://doi.org/10.3990/1.9789036537353Locked-in Biomimetic Surface Gradients that are Tunable in Size, Density and Functionalization (2014)ChemPhysChem, 15(16), 3460-3465. Krabbenborg, S., van Weerd, J., Karperien, H. B. J., Jonkheijm, P. & Huskens, J.https://doi.org/10.1002/cphc.201402509ANIMO: a tool for modeling biological pathway dynamics (2014)[Contribution to conference › Abstract] TERMIS-EU Chapter Meeting 2014<br/>. Schivo, S., Scholma, J., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N.https://doi.org/10.1002/term.1931ECHO: the executable chondrocyte (2014)In Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting (pp. 54-54) (s1; Vol. 8). Wiley. Scholma, J., Schivo, S., Kerkhofs, J., Langerak, R., Karperien, H. B. J., van de Pol, J. C., Geris, L. & Post, J. N.https://doi.org/10.1002/term.1931Microfluidic production of enzymatically crosslinked Dextran-Tyramine microgels to improve type 1 diabetes therapies (2014)[Contribution to conference › Abstract] 1st international Conference on Micro & Nano Fluidics, FLOW 2014. Henke, S. J., Leijten, J. C. H., Kemna, E., van den Berg, A., Dijkstra, P. J., van Apeldoorn, A. A. & Karperien, H. B. J.Modeling Biological Pathway Dynamics With Timed Automata (2014)IEEE journal of biomedical and health informatics, 18(3), 832-839. Schivo, S., Scholma, J., Wanders, B., Urquidi Camacho, R. A., van der Vet, P. E., Karperien, M., Langerak, R., van de Pol, J. & Post, J. N.https://doi.org/10.1109/JBHI.2013.2292880DKK1 FRZB GREM1 Prevent IL1 Induced Articular Cartilage Degradation (2014)[Contribution to conference › Abstract] 2014 OARSI World Congress on Osteoarthritis. Zhong, L., Karperien, H. B. J. & Post, J. N.Lipids as mediators of chondrogenesis (2014)[Contribution to conference › Abstract] 2014 OARSI World Congress on Osteoarthritis. Georgi, N., Cillero Pastor, B., Eijkel, G., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J.https://doi.org/10.1016/j.joca.2014.02.104Protein fibrils as scaffold material for cartilage tissue engineering - effects on cell viability and proliferation (2014)[Contribution to conference › Abstract] 2014 OARSI World Congress on Osteoarthritis. van Dalen, M. C. E., Karperien, H. B. J., Subramaniam, V., Claessens, M. M. A. E. & Post, J. N.Setting Parameters for Biological Models With ANIMO (2014)In Proceedings 1st International Workshop on Synthesis of Continuous Parameters (pp. 35-47) (Electronic Proceedings in Theoretical Computer Science; Vol. 145). Open Publishing Association. Schivo, S., Scholma, J., Karperien, H. B. J., Post, J. N., van de Pol, J. C. & Langerak, R.https://doi.org/10.4204/EPTCS.145.5An echo in biology: validating the executable chondrocyte (2014)In 2014 World Congress on Osteoarthritis (pp. S157-S157) (Osteoarthritis and Cartilage; Vol. 22). Elsevier. Scholma, J., Schivo, S., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N.https://doi.org/10.1016/j.joca.2014.02.291Mesenchymal Stromal/Stem Cell–or Chondrocyte-Seeded Microcarriers as Building Blocks for Cartilage Tissue Engineering (2014)Tissue engineering. Part A, 20(17-18), 2513-2523. Georgi, N., van Blitterswijk, C. & Karperien, H. B. J.https://doi.org/10.1089/ten.tea.2013.0681Immuno-Protective Membrane-Based Scaffolds For Extra Hepatic Islet Transplantation (2014)[Contribution to conference › Abstract] 4th Joint EPITA and AIDPIT Winter Symposium, Innsbruck, Austria. Groot Nibbelink, M., Skrzypek, K., de Koning, E. J. P., Karperien, H. B. J., Stamatialis, D. & van Apeldoorn, A. A.Microfluidic Encapsulation of Beta cells: comparing the suitability of enzymatic, ionic and photo crosslinking hydrogels (2014)[Contribution to conference › Abstract] EPITA and AIDPIT Innsbrück, Austria. Henke, S. J., Leijten, J. C. H., Kemna, E., van den Berg, A., Dijkstra, P. J., van Apeldoorn, A. A. & Karperien, H. B. J.Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches (2014)Advanced materials, 26(16), 2592-2599. Leferink, A., Schipper, D., Arts, E., Vrij, E., Rivron, N., Karperien, M., Mittmann, K., van Blitterswijk, C., Moroni, L. & Truckenmüller, R.https://doi.org/10.1002/adma.201304539A Supramolecular Host-Guest Carrier System for Growth Factors Employing VHH Fragments (2014)Journal of the American Chemical Society, 136(36), 12675-12681. Cabanas Danés, J., Rodrigues, E. D., Landman, E., van Weerd, J., van Blitterswijk, C., Verrips, T., Huskens, J., Karperien, M. & Jonkheijm, P.https://doi.org/10.1021/ja505695wBiological networks 101: computational modeling for molecular biologists (2014)Gene, 533(42), 379-384. Scholma, J., Schivo, S., Urquidi Camacho, R. A., van de Pol, J. C., Karperien, H. B. J. & Post, J. N.https://doi.org/10.1016/j.gene.2013.10.010Cartilage adhesive and mechanical properties of enzymatically crosslinked polysaccharide tyramine conjugate hydrogels (2014)Polymers for advanced technologies, 25(5), 568-574. Wang, R., Leber, N., Buhl, C., Verdonschot, N. J. J., Dijkstra, P. J. & Karperien, H. B. J.https://doi.org/10.1002/pat.3286Clinical outcome 3 years after autologous chondrocyte implantation does not correlate with the expression of a predefined gene marker set in chondrocytes prior to implantation but is associated with critical signaling pathways (2014)Orthopaedic Journal of Sports Medicine, 2(9). Stenberg, J., de Windt, T. S., Synnergren, J., Hynsjö, L., van der Lee, J., Saris, D. B. F., Brittberg, M., Peterson, L. & Lindahl, A.https://doi.org/10.1177/2325967114550781Copy number variants in patients with short stature (2014)European journal of human genetics, 22(5), 602-609. van Duyvenvoorde, H. A., Lui, J. C., Kant, S. G., Oostdijk, W., Gijsbers, A. C. J., Hoffer, M. J. V., Karperien, M., Walenkamp, M. J. E., Noordam, C., Voorhoeve, P. G., Mericq, V., Pereira, A. M., Claahsen-van de Grinten, H. L., van Gool, S. A., Breuning, M. H., Losekoot, M., Baron, J., Ruivenkamp, C. A. L. & Wit, J. M.https://doi.org/10.1038/ejhg.2013.203Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes (2014)Arthritis research & therapy, 16(441), -. Article 441. Tsuchida, A. I., Beekhuizen, M., 't Hart, M. C., Radstake, T. R. D. J., Dhert, W. J. A., Saris, D. B. F., van Osch, G. J. V. M. & Creemers, L. B.https://doi.org/10.1186/s13075-014-0441-0Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line (2014)Cartilage, 5(3), 181-189. Landman, E., Periyasamy, P. C., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J.https://doi.org/10.1177/1947603514525036Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy (2014)Tissue engineering. Part C: Methods, 20(2), 160-168. Wu, L., Gonzalez, S., Shah, S., Kyupelyan, L., Petrigliano, F. A., McAllister, D. R., Adams, J. S., Karperien, H. B. J., Tuan, T.-L., Benya, P. D. & Evseenko, D.https://doi.org/10.1089/ten.TEC.2013.0056High Throughput Micro-Well Generation of Hepatocyte Micro-Aggregates for Tissue Engineering (2014)PLoS ONE, 9(8), -. Article e105171. Gevaert, E., Dollé, L., Billiet, T., Dubruel, P., van Grunsven, L., van Apeldoorn, A. A. & Cornelissen, R.https://doi.org/10.1371/journal.pone.0105171Hydrogels by supramolecular crosslinking of terpyridine end group functionalized 8-arm poly(ethylene glycol) (2014)Soft matter, 10(37), 7328-7336. Wang, R., Geven, M. A., Dijkstra, P. J., Martens, P. & Karperien, H. B. J.https://doi.org/10.1039/C4SM01162GHydrogels in a historical perspective: From simple networks to smart materials (2014)Journal of controlled release, 190, 254-273. Buwalda, S. J., Boere, K. W. M., Dijkstra, P. J., Feijen, J., Vermonden, T. & Hennink, W. E.https://doi.org/10.1016/j.jconrel.2014.03.052Identification of novel SHOX target genes in the developing limb using a transgenic mouse model (2014)PLoS ONE, 9(6), -. Article e98543. Beiser, K. U., Glaser, A., Kleinschmidt, K., Scholl, I., Röth, R., Li, L., Gretz, N., Mechtersheimer, G., Karperien, H. B. J., Marchini, A., Richter, W. & Rappold, G. A.https://doi.org/10.1371/journal.pone.0098543Injectable hydrogels for cartilage repair (2014)Osteoarthritis and cartilage, 22(Suppl.), S151-S152. Both, S. K., Wang, R., Dijkstra, P. J. & Karperien, H. B. J.https://doi.org/10.1016/j.joca.2014.02.282Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Two-year follow-up of a prospective randomized trial (2014)The American journal of sports medicine, 42(6), 1384-1394. Saris, D., Price, A., Widuchowski, W., Bertrand-Marchand, M., Caron, J., Drogset, J. O., Emans, P., Podskubka, A., Tsuchida, A. I., Kili, S., Levine, D. & Brittberg, M.https://doi.org/10.1177/0363546514528093Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate (2014)Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13954-13959. Leijten, J., Georgi, N., Moreira Teixeira, L., van Blitterswijk, C., Post, J. N. & Karperien, M.https://doi.org/10.1073/pnas.1410977111Producing artificial chondrons for improved cartilage repair (2014)Osteoarthritis and cartilage, 22(Suppl.), S485-S486. Kamperman, T., Leijten, J. C. H., Henke, S. J. & Karperien, M.https://doi.org/10.1016/j.joca.2014.02.921Tissue Formation during Embryogenesis (2014)In Tissue Engineering (pp. 67-109). Elsevier. Karperien, M., Roelen, B. A. J., Poelmann, R. E., Gittenberger-de Groot, A., Hierck, B. P., DeRuiter, M. C., Meijer, D. & Gibbs, S.https://doi.org/10.1016/B978-0-12-420145-3.00003-1Treatment algorithm for articular cartilage repair of the knee: Towards patient profiling using evidence-based tools (2014)In Techniques in Cartilage Repair Surgery (pp. 23-31). Springer. de Windt, T. S. & Saris, D. B. F.https://doi.org/10.1007/978-3-642-41921-8_3
2013
Introducing small cationic groups into 4-armed PLLAePEG copolymers leads to preferred micellization over thermo-reversible gelation (2013)Polymer, 54(26), 6894-6901. Wennink, J. W. H., Signori, F., Signori, F., Karperien, H. B. J., Bronco, S., Feijen, J. & Dijkstra, P. J.https://doi.org/10.1016/j.polymer.2013.11.007Maintenance of multi-potential differentiation capacity of human mesenchymal stem cells on polymeric rapid prototyped 3D scaffolds (2013)[Contribution to conference › Poster] Till & McCulloch meetings. Leferink, A. M., Karperien, H. B. J., van Blitterswijk, C. & Moroni, L.Label-Free Detection of Insulin and Glucagon within Human Islets of Langerhans Using Raman Spectroscopy (2013)PLoS ONE, 8(10), e78148-e78148. Hilderink, J., Otto, C., Slump, C. H., Lenferink, A. T. M., Engelse, M. A., van Blitterswijk, C., de Koning, E. J. P., Karperien, H. B. J. & van Apeldoorn, A. A.https://doi.org/10.1371/journal.pone.0078148Beating diabetes: strategies to improve pancreatic islet transplantation (2013)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Hilderink, J.https://doi.org/10.3990/1.9789036507752Amyloid Scaffolds for Cartilage Tissue Engineering: The Effect of Amyloid Structures on Cell Viability and Proliferation (2013)[Contribution to conference › Poster] Annual Dutch meeting on Molecular and Cellular Biophysics 2013. van Dalen, M. C. E., Karperien, H. B. J., Subramaniam, V., Post, J. N. & Claessens, M. M. A. E.Modulation of cholesterol metabolism for better cartilage formation by influencing FGF signaling (2013)[Contribution to conference › Poster] Annual Dutch meeting on Molecular and Cellular Biophysics 2013. Georgi, N., Cillero Pastor, B., Wu, L., Eijkel, G., Kiss, A., Gratton, R., WIlson, B., Heeren, R. M. A., Karperien, H. B. J. & Post, J. N.GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis associated factors (2013)Arthritis research & therapy, 15(5), 1-11. Article R126. Leijten, J. C. H., Bos, S. D., Landman, E., Georgi, N., Jahr, H., Meulenbelt, I., Post, J. N., van Blitterswijk, C. & Karperien, H. B. J.https://doi.org/10.1186/ar4306Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures (2013)Tissue engineering. Part B: Reviews, 19(1), 31-40. Leijten, J. C. H., Georgi, N., Wu, L., van Blitterswijk, C. & Karperien, H. B. J.https://doi.org/10.1089/ten.TEB.2012.0273Branched biodegradable polymers, a macromonomer, processes for the preparation of same, and their use (2013)[Patent › Patent] (Submitted). Feijen, J., Zhong, Z. & Dijkstra, P. J.http://www.uspto.gov/web/patents/patog/week30/OG/html/1392-4/US08492505-20130723.htmlPleisters plakken (2013)[Book/Report › Inaugural speech]. University of Twente. Karperien, H. B. J.Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans (2013)PLoS ONE, 8(5). Article e64772. Buitinga, M., Truckenmüller, R., Engelse, M. A., Moroni, L., ten Hoopen, H. W. M., van Blitterswijk, C. A., de Koning, E. J. P., van Apeldoorn, A. A. & Karperien, M.https://doi.org/10.1371/journal.pone.0064772The effect of donor variation and senescence on endothelial differentiation of human mesenchymal stromal cells (2013)Tissue engineering. Part A, 19(21-22), 2318-2329. Portalska, K. K., Groen, N., Krenning, G., Georgi, N., Mentink-Leusink, A., Harmsen, M. C., van Blitterswijk, C. & de Boer, J.https://doi.org/10.1089/ten.TEA.2012.0646Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: Perspectives from stem cell biology and molecular medicine (2013)Journal of cellular physiology, 228(5), 938-944. 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B. J.Biodegradable hydrogels by physical and enzymatic crosslinking of biomacromolecules (2013)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Wennink, J. W. H.https://doi.org/10.39990/1.9789036535038Insulin-like-growth-factor-I enhances proliferation and differentiation of human mesenchymal stromal cells in vitro (2013)Tissue engineering. Part A, 19(15-16), 1817-1828. Doorn, J., Roberts, S. J., Hilderink, J., Groen, N., van Apeldoorn, A. A., van Blitterswijk, C., Schrooten, J. & de Boer, J.https://doi.org/10.1089/ten.TEA.2012.0522Multiple choice: leveraging instructive culture models to improve cartilage tissue engineering (2013)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Georgi, N.https://doi.org/10.3990/1.9789036535205Molecular modulation of articular cartilage degradation (2013)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Landman, E. B. 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2012
Dextran-hyaluronic acid based hydrogels (2012)[Patent › Patent]. Jin, R., Moreira Teixeira, L., Feijen, J., Dijkstra, P. J. & Karperien, M.Sotos Syndrome Is Associated with Deregulation of the MAPK/ERK-Signaling Pathway (2012)PLoS ONE, 7(11). Article e49229. Visser, R., Landman, E. B. M., Goeman, J., Wit, J. M. & Karperien, M.https://doi.org/10.1371/journal.pone.0049229Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis (2012)[Non-textual form › Web publication/site]. F1000 Rheumatology & Clinical Immunology. Leijten, J. C. H., Emons, J., Sticht, C., van Gool, S., Decker, E., Uitterlinden, A., Rappold, G., Hofman, A., Rivadeneira, F., Scherjon, S., Wit, J. M., van Meurs, J., van Blitterswijk, C. & Karperien, H. B. J.https://doi.org/10.3410/f.717961030.793463944Hydrogels based on polymers of dextran tyramine and tyramine conjugates of natural polymers (2012)[Patent › Patent]. Feijen, J., Karperien, M., Jin, R., Moreira Teixeira, L. & Dijkstra, P. J.Modelling biological pathway dynamics with Timed Automata (2012)In 2012 IEEE 12th International Conference on Bioinformatics and Bioengineering (BIBE 2012) (pp. 447-453). IEEE. Schivo, S., Scholma, J., Wanders, B., Urquidi Camacho, R. A., van der Vet, P. E., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N.https://doi.org/10.1109/BIBE.2012.6399719Stress-strain measurements of single micro and nanoscale fibers with modified AFM cantilevers (2012)[Contribution to conference › Poster] 4th Multifrequency Conference. Bennink, M. L., van der Werf, K., Sijbrandi, N. J., Dijkstra, P. J., Feijen, J. & Subramaniam, V.Poly(bisoxalamides) (2012)[Patent › Patent]. Broos, R., Sijbrandi, N., Dijkstra, P. & Feijen, J.Mesenchymal stem cells as trophic mediators in cartilage regeneration (2012)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Wu, L.https://doi.org/10.3990/1.9789036533973Wnt signaling in cartilage development and degeneration (2012)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Ma, B.https://doi.org/10.3990/1.9789036534222Improved Neocartilage Fomation in Dex-TA Hydrogels by Seeding Cell Micro-aggregates Produced in A (2012)[Contribution to conference › Poster] 9th World Biomaterials Congress, WBC 2012. Leijten, J. C. H., Moreira Teixeira, L., Sobral, J., Jin, R., van Apeldoorn, A. A., Feijen, J., van Blitterswijk, C., Dijkstra, P. J. & Karperien, H. B. J.Screening in vitro and in vivo to Reduce Animal Experiments (2012)[Contribution to conference › Poster] 9th World Biomaterials Congress, WBC 2012. Higuera Sierra, G., Wu, L., Moreira Teixeira, L., Leijten, J. C. H., Karperien, H. B. J., van Blitterswijk, C., Moroni, L. & van Dalum, J.Vroege opsporing Artrose wordt eenvoudiger (2012)Reuma Magazine.nl, -. Leijten, J. C. H.http://www.reumafonds.nl/actueel/nieuwsoverzicht/2012/vroege-opsporing-artrose-dichterbijA quest for copy number variations causing extreme tall stature (2012)[Contribution to conference › Poster] European Society for Pediatric Endocrinology Annual Meeting 2012. Duyvenvoorde, H. A., Ruivenkamp, C. A., Mul, D., Oostdijk, W., Karperien, M., Losekoot, M., Pereira, A. M., Kant, S. G. & Wit, J. M.Bioactive hydrogels to induce angiogenesis and improve islets of Langerhans viability (2012)[Contribution to conference › Poster] 20th NBTE Annual Meeting 2011. Marchioli, G., Engelse, M. A., Dijkstra, P. J., de Koning, E. J. P., Karperien, H. B. J., van Blitterswijk, C., Moroni, L. & van Apeldoorn, A. A.Copy number variations in patients with idiopathic short stature (2012)[Contribution to conference › Poster] European Society for Pediatric Endocrinology Annual Meeting 2012. van Duyvenvoorde, H. A., Lui, J., Kant, S. G., Oostdijk, W., Gijsbers, A. C. J., Karperien, M., Walenkamp, M. J. E., Noordam, C., Voorhoeve, P. G., Mericq, V., van Gool, S. A., Breuning, M. H., Losekoot, M., Baron, J., Ruivenkamp, C. A. & Wit, J. M.Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering (2012)Biomaterials, 33(5), 1281-1290. Moreira Teixeira, L., Feijen, J., van Blitterswijk, C., Dijkstra, P. J. & Karperien, H. B. J.https://doi.org/10.1016/j.biomaterials.2011.10.067Fetal Mesenchymal Stromal Cells Differentiating towards Chondrocytes Acquire a Gene Expression Profile Resembling Human Growth Plate Cartilage (2012)PLoS ONE, 7(11), 1-11. Article e44561. van Gool, S. A., Emons, J. A. M., Leijten, J. C. H., Decker, E., Sticht, C., van Houwelingen, J. C., Goeman, J. J., Kleijburg, C., Scherjon, S., Gretz, N., Wit, J. M., Rappold, G., Post, J. N. & Karperien, H. B. J.https://doi.org/10.1371/journal.pone.0044561Fluorescently Labeled Branched Polymers and Thermal Responsive Nanoparticles for Live Cell Imaging (2012)Macromolecular bioscience, 12(4), 465-474. 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H., van Blitterswijk, C. & Karperien, H. B. J.https://doi.org/10.1038/nrrheum.2012.82Poly(ethylene glycol)-poly(L -lactide) star block copolymer hydrogels crosslinked by metal-ligand coordination (2012)Journal of polymer science. Part A: Polymer chemistry, 50(9), 1783-1791. Buwalda, S. J., Dijkstra, P. J. & Feijen, J.https://doi.org/10.1002/pola.25945Recent insights from scanning electron microscopic assessment of durable polymer-coated drug-eluting stents (2012)Interventional cardiology, 4(6), 661-674. Basalus, M. W. Z., Tandjung, K., Sen, H., van Apeldoorn, A. A., Grijpma, D. W. & von Birgelen, C.https://doi.org/10.2217/ica.12.67Recognizing different tissues in human fetal femur cartilage by label-free Raman microspectroscopy (2012)Journal of biomedical optics, 17(11), -. Article 116012. Kunstar, A., Leijten, J. C. H., van Leuveren, S., Hilderink, J., Otto, C., van Blitterswijk, C., Karperien, H. B. J. & van Apeldoorn, A. 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2011
HYDROGELS BASED ON POLYMERS OF DEXTRAN TYRAMINE AND TYRAMINE CONJUGATES OF NATURAL POLYMERS (2011)[Patent › Patent]. Karperien, H. B. J., Jin, R., Moreira Teixeira, L., Feijen,, J. & Dijkstra, P. J.Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells (2011)Journal of tissue engineering and regenerative medicine, 5(3), 180-190. Both, S. K., van Apeldoorn, A. A., Jukes, J. M., Englund, M. C. O., Hyllner, J., van Blitterswijk, C. & de Boer, J.https://doi.org/10.1002/term.303Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo (2011)Clinical sarcoma research, 1. Article 5. Meijer, D., Gelderblom, H., Karperien, M., Cleton-Jansen, A.-M., Hogendoorn, P. C. W. & Bovée, J. V. M. G.https://doi.org/10.1186/2045-3329-1-5Genome-wide association identifies three new susceptibility loci for Paget's disease of bone (2011)Nature genetics, 43(7), 685-689. Albagha, O. M. E., Wani, S. E., Visconti, M. R., Alonso, N., Goodman, K., Brandi, M. L., Cundy, T., Chung, P. Y. J., Dargie, R., Devogelaer, J.-P., Falchetti, A., Fraser, W. D., Gennari, L., Gianfrancesco, F., Hooper, M. J., van Hul, W., Isaia, G., Nicholson, G. C., Nuti, R., … Karperien, H. B. J.https://doi.org/10.1038/ng.845
2010
Dextran-tyramine Hydrogels for Cartilage Repair: Enhanced Chondrogenicity by Engraftment with Hyaluronic Acid and Heparin (2010)[Contribution to conference › Abstract] TERMIS-EU Chapter Meeting 2010. Moreira Teixeira, L., Jin, R., Dijkstra, P. T. S., van Blitterswijk, C., Feijen, J. & Karperien, H. B. J.https://www.termis.org/docs/eu10_abstracts/TERMIS2010_0371.pdfMateriomics: Dealing with complexity in tissue engineering (2010)European cells & materials, 20(SUPPL. 1). van Blitterswijk, C. A., Stamatialis, D., Unadkat, H., Papenburg, B., Rouwkema, J., Truckenmuller, R., van Apeldoorn, A., Wessling, M. & de Boer, J.
2009
Scaffold for diabetes treatment (2009)[Patent › Patent] (Submitted). van Apeldoorn, A. A., van Blitterswijk, C., Engelse, M. A., de Koning, E. J. P. & Karperien, H. B. J.
2007
Cell-based and molecular imaging tools for validating new therapies in the treatment of bone metabolic disorders and metastases (2007)Current opinion in molecular therapeutics, 8(6), 477-479. Kaijzel, E. L., Karperien, M., van der Horst, G., van der Pluijm, G., Löwik, C. W. G. M. & Chan, A.
2003
Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET) (2003)Biochemical Society transactions, 31(5), 1020-1027. Lidke, D. S., Nagy, P., Barisas, B. G., Heintzmann, R., Post, J. N., Lidke, K. A., Clayton, A. H. A., Arndt-jovin, D. J. & Jovin, T. M.https://doi.org/10.1042/bst0311020
2001
Nuclear localization signals in the Xenopus FGF embryonic early response 1 protein (2001)FEBS letters, 502(1-2), 41-45. Post, J. N., Gillespie, L. L. & Paterno, G. D.https://doi.org/10.1016/S0014-5793(01)02653-9