Ellie Landman (1985) obtained her master’s degree in Biomedical Sciences at the Radboud University Nijmegen in 2008. She did a major in Human Pathobiology and minors in Clinical Chemistry and Drug Research. In October 2008, she started working as a PhD student in the Tissue Regeneration group of Clemens van Blitterswijk at the University of Twente, under the supervision of Marcel Karperien. Since January 2012, the group of Marcel Karperien continues as a new group, Developmental BioEngineering.
In osteoarthritis, the balance between anabolic and catabolic processes is shifted towards excessive breakdown of cartilage extracellular matrix. Even though the exact etiology of osteoarthritis remains to be elucidated, wnt/β-catenin signaling has been found to play an important role in the onset and progression of osteoarthritis.
During her PhD project, Ellie is focusing on the involvement of wnt/β-catenin signaling in healthy cartilage and degenerative cartilage diseases. She uses small molecules to modulate the wnt/β-catenin signaling pathway and she studies the histological and molecular effects in vitro and in vivo.
Ellie Landman defended her thesis titled “Molecular modulation of articular cartilage degradation”on 15 March 2013