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2026
Self-Feeding Living Materials Enabled by Cell Responsive Glycogen Nanoparticles as Metabolic Batteries (2026) Advanced materials, 38(52) . Article e74812 . Gurian, M. , Willemen, N. G. A. , Porsul, I. R. , Bassous, N. , Hiemstra, J. , Na, Y. , Gawlitta, D. , Shin, S. R. & Leijten, J. https://doi.org/10.1002/adma.74812 Zein-Ceria Hybrid Microparticles Enable Long-Term ROS-Scavenging Oxygenation for Osteogenic Microtissues Engineering (2026) Advanced materials, 38(44) . Article e73849 . Byun, H. , Han, S. G. , Willemen, N. , Park, E. , Govindaraj, K. , Jeong, S. H. , Jeon, O. , Alsberg, E. , Leijten, J. , Shin, H. & Shin, S. R. https://doi.org/10.1002/adma.73849 Bioluminescence-based biosensing of NF-κB activity for osteoarthritis drug screening in a cartilage-on-chip model (2026) Biosensors & Bioelectronics: X, 30 . Article 100786 . Gudi, S. , Araújo-Gomes, N. , Conceição, F. , van den Akker, G. , Welting, T. , Narcisi, R. , Karperien, M. & Moreira Teixeira, L. https://doi.org/10.1016/j.biosx.2026.100786 Effects of Compression on Extracellular Matrix Synthesis by Chondrocytes and Chondrosarcoma Cells (2026) Cartilage (E-pub ahead of print/First online) . Paggi, C. A. , Porsul, I. , Le Gac, S. & Karperien, M. https://doi.org/10.1177/19476035261460455 Investigating transcription factor dynamics in health and disease using FRAP (2026) FEBS letters (E-pub ahead of print/First online) . Govindaraj, K. , Garzon, C. V. , Velasco, J. J. & Post, J. N. https://doi.org/10.1002/1873-3468.70405 Defective alveolar regeneration in emphysema: Identifying dysfunctional cellular crosstalk and novel therapeutic opportunities for tissue repair (2026) European Respiratory Review, 35(181) . Article 260090 . Torre Flores, L. P. , Jalink, P. J. , Fuentes-Mateos, R. , Erasmus, M. , van Oorschot, M. E. , Gan, T. , Hoffmann, R. , Zwaginga, J. J. , Brandsma, C.-A. , Nawijn, M. , Chen, L. , Homkar, N. , Prakash, J. , Hiemstra, P. S. , Van der Does, A. M. , Leijten, J. , Gosens, R. & Heijink, I. https://doi.org/10.1183/16000617.0090-2026 Modelling stem cell differentiation related processes: A practical overview for biologists (2026) FEBS letters (E-pub ahead of print/First online) . Zeegelaar, R. , Yan, X. , Klomp, L. J. , Schivo, S. & Post, J. N. https://doi.org/10.1002/1873-3468.70395 Sex-related differences in femorotibial cartilage thickness: A matched pair analysis (2026) Annals of Anatomy, 266 . Article 152824 . Spoelder, N. , Turmezei, T. D. , Kessler, D. A. , Mackay, J. W. , Mastbergen, S. C. , Karperien, M. , Jansen, M. P. & Eckstein, F. https://doi.org/10.1016/j.aanat.2026.152824 A Synovium-on-Chip Platform to Study Multicellular Interactions in Arthritis (2026) Advanced healthcare materials, 15(15) . Article e04857 . Spoelstra, L. R. , Semmekrot, F. R. , Araújo-Gomes, N. , Wijnperle, D. , Helsen, M. M. A. , Van Den Bosch, M. H. J. , Segerink, L. I. , Le Gac, S. & Karperien, M. https://doi.org/10.1002/adhm.202504857 Non-oral tissue regeneration, angiogenesis, and healing with enamel matrix derivative (2026) Academia Biology, 4(1) . Zada, O. , Serrano-Larrea, C. , Karperien, M. & Veen, E. J. D. https://doi.org/10.20935/AcadBiol8227 A Quantitative Printability Framework for Programmable Assembly of Pre‐Vascular Patterns via Laser‐Induced Forward Transfer (2026) Advanced healthcare materials, 15(8) . Article e03665 . Bosmans, C. , Ginés Rodriguez, N. , Hernández, U. J. G. , Rivas, D. F. , Karperien, M. , Malda, J. , Teixeira, L. M. , Levato, R. & Leijten, J. https://doi.org/10.1002/adhm.202503665 Guiding cell behaviour via intracellular crowding (2026) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Meteling, M. A. W. https://doi.org/10.3990/1.9789036570107 Advanced biofabrication techniques of muscle cell-powered biohybrid robots (2026) International Journal of Extreme Manufacturing, 8(1) . Article 012007 . Wang, N. , Yang, Y. , Rezaei, Z. , Hernández, M. J. V. , Govindaraj, K. , Garzon, C. V. , Colin, M. , Rodríguez, A. d. J. A. , Martinez Blanco, A. D. , Velasco, J. J. , Lee, J. , Choi, J. W. & Shin, S. R. https://doi.org/10.1088/2631-7990/ae0bc7 Tailoring human joint-on-a-chip: From biological principles, materials, to disease modeling (2026) Materials Today Bio, 36 . Article 102549 . Wang, X. , Ye Ong, L. J. , Karperien, M. & Wen, C. https://doi.org/10.1016/j.mtbio.2025.102549 Tailorable Biofunctionalization of Poly(acrylamide) Hydrogels via Firefly Luciferin-Bioinspired Click Ligation Accelerates Cell Attachment, Spreading, and Proliferation (2026) ACS Applied Materials & Interfaces, 18(3) , 4805-4817 . Wolfel, A. , Jin, M. , Araújo-Gomes, N. , Becker, M. , Leijten, J. , Moreira Teixeira, L. & Paez, J. I. https://doi.org/10.1021/acsami.5c20298 Intracellular crowding links dimensionality to cell fate through a mechano-metabolic signalling axis (2026) [Working paper › Preprint] . bioRxiv . Meteling, M. , van Loo, B. , Suurmond, C. , Mulders, R. , Wijngaarden, R. , Govindaraj, K. , Geris, L. , Meulenbelt, I. , Ramos, Y. F. M. , Moreira Teixera, L. & Leijten, J. https://doi.org/10.64898/2026.01.20.700361 Molecular insights into heart field-specific cardiomyocyte differentiation - A computational study: Boolean model of cardiac development (2026) PLoS ONE, 21(1) . Article e0340054 . Zeegelaar, R. , Limana, F. , Argyris, G. & Post, J. N. https://doi.org/10.1371/journal.pone.0340054 Bone-on-chip models (2026) In Genetics of Bone Biology and Skeletal Disease (pp. 83-104) . Elsevier Doyma . Conceição, F. , Araújo-Gomes, N. , Kocer, G. , Jin, J. , Klein-Nulend, J. , Nolte, P. A. , Jonkheijm, P. , Bravenboer, N. & Moreira Teixeira, L. https://doi.org/10.1016/B978-0-443-13683-2.00013-X Engineering osteoclast resorption units via sacrificial microgels in a bone-on-chip platform (2026) Lab on a chip, 26(2) , 331-344 . Conceição, F. , Araújo-Gomes, N. , Husch, J. F. A. , Becker, M. , van den Beucken, J. J. J. P. , Leijten, J. & Moreira Teixeira, L. https://doi.org/10.1039/d5lc00682a
2025
DANSE: A pipeline for dynamic modelling of time-series multi-omics data (2025) BMC bioinformatics, 27(1) . Article 28 (E-pub ahead of print/First online) . Jansen Klomp, L. F. , Yan, X. , Snabel, R. R. , Veenstra, G. J. C. , Meijer, H. G. E. & Post, J. N. https://doi.org/10.1186/s12859-025-06354-3 Self-Feeding of Engineered Tissues via Controlled Glucose Release Facilitates Survival and Vascularization of Living Implants (2025) Advanced functional materials . Article e28636 (E-pub ahead of print/First online) . Gurian, M. , Allijn, I. E. , Veenendaal, L. , Bassous, N. , Shin, S. R. & Leijten, J. https://doi.org/10.1002/adfm.202528636 Arresting Microphase Separation Encodes Material Mechanics by Sculpting Microarchitectures and Local Polymer Enrichment (2025) Advanced materials . Article e12578 (E-pub ahead of print/First online) . Johnbosco, C. , Dalenoord, F. , Hiemstra, J. , Na, Y. , Wolfel, A. , Bosmans, C. , Gering, C. , Willemen, N. , Shin, S. R. & Leijten, J. https://doi.org/10.1002/adma.202512578 Organ-on-chip technologies: Novel tools with the potential to revolutionize osteoarthritis research and clinical development (2025) Osteoarthritis and Cartilage Open, 7(4) . Article 100686 . Paggi, C. A. https://doi.org/10.1016/j.ocarto.2025.100686 Connecting the D.O.T.S.: Design of fluidic circuit boards for multi-OoC platforms using CAD Tools for Standardization (2025) In 2025 IEEE/ACM International Conference On Computer Aided Design (ICCAD) . IEEE . Spoelstra, L. R. , Kramer, M. , Rietveld, J. , Loessberg-Zahl, J. T. & Segerink, L. https://doi.org/10.1109/ICCAD66269.2025.11240924 Automated routing for fluidic and pneumatic channels in standardized microfluidic platforms using CAD software (2025) [Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025 . Spoelstra, L. R. , Kramer, M. , Karperien, M. , Le Gac, S. & Segerink, L. Computational toolset for fluidic network-to-layout translation applied in FCB design for chemical gradients in parallelized organ-on-chips (2025) [Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025 . Spoelstra, L. R. , Emmerich, M. , Rietveld, J. , Berendsen, J. T. W. , Loessberg-Zahl, J. T. , Wille, R. & Segerink, L. Effect of Microbial Stimuli and Bone Morphogenetic Protein 2 on Ectopic Bone Formation (2025) Tissue engineering. Part A, 31(21-22) , 1227-1238 . Rahmani, N. R. , Duits, A. , Khokhani, P. , Croes, M. , Kaludjerovic, V. , Gawlitta, D. , Weinans, H. & Kruyt, M. C. https://doi.org/10.1089/ten.tea.2025.0020 Aqueous two-phase system enabled advances for biofabrication (2025) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Becker, M. L. https://doi.org/10.3990/1.9789036568265 Novel strategies to encode engineered living matter with self-feeding properties (2025) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Gurian, M. https://doi.org/10.3990/1.9789036568302 Bioxolography Using Diphenyliodonium Chloride and N-Vinylpyrrolidone Enables Rapid High-Resolution Volumetric 3D Printing of Spatially Encoded Living Matter (2025) Advanced materials, 37(37) . Article 2501052 . Wolfel, A. , Johnbosco, C. , Anspach, A. , Meteling, M. , Olijve, J. , König, N. F. & Leijten, J. https://doi.org/10.1002/adma.202501052 Developing a cartilage-on-chip platform for osteoarthritis (2025) Orthopaedic proceedings, 107-B(SUPP. 6) , 109-109 . Le, T. , Zoetebier, B. , Damle, A. , Barbero, A. , Martin, I. , Lauwers, E. , Paggi, C. A. & Karperien, M. https://doi.org/10.1302/1358-992X.2025.6.109 Injectable hydrogels for VHH delivery to restore joint homeostasis (2025) Orthopaedic proceedings, 107-B(SUPP_6) , 110-110 . Serrano Larrea, C. , Morshuis, L. , Zhong, L. , Zambonino, M. , Le, T. , Semmekrot, F. , Zoetebier, B. & Karperien, M. https://doi.org/10.1302/1358-992X.2025.6.110 Targeting Chondromodulin-I (Cnmd) for novel osteoarthritis interventions: In vivo and 3D model insights (2025) Orthopaedic proceedings, 107-B(Suppl. 6) , 107-107 . Reyes Alcaraz, V. , Pattappa, G. , Müller-Deubert, S. , Serrano Larrea, C. , Le, N. X. T. , Rudert, M. , Karperien, M. & Docheva, D. https://doi.org/10.1302/1358-992X.2025.6.107 Mechanically Tunable Biofabricated Channels Enable Mimicking Arterial Pulsatility and Dynamic Tissue Actuation (2025) Small Science, 5(9) . Article 2500176 . Bosmans, C. , Becker, M. , Moreira Teixeira, L. S. & Leijten, J. https://doi.org/10.1002/smsc.202500176 A human engineered mini-heart platform for mimicking ventricular pump function (2025) [Working paper › Preprint] . bioRxiv . Ribeiro, M. C. , Cano-Jorge, M. , ten Den, S. , Snippert, D. , Karperien, M. , Kamperman, T. , Lajoinie, G. P. R. , Versluis, M. & Passier, R. https://doi.org/10.1101/2025.08.25.672056 Vessels in the void: Microtissue packing for vascular integration in engineered tissues (2025) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Schot, M. R. https://doi.org/10.3990/1.9789036567909 Identification of models describing gene expression data leveraging machine learning methods (2025) Interface focus, 15(3) . Article 20250014 . Jansen Klomp, L. F. , Queirolo, E. , Post, J. N. , Meijer, H. G. E. & Brune, C. https://doi.org/10.1098/rsfs.2025.0014 A Transparent, Antimicrobial, Bio-Ionic Liquid Functionalized Hydrogel for Corneal Injury Repair (2025) ACS Applied Materials & Interfaces, 17(33) , 46596-46609 . Kanjilal, B. , Krishnadoss, V. , Banerjee, A. , Basu, P. , Tonmoy, T. I. , Leijten, J. , Soll, S. M. , Masoumi, A. , Park, B. H. & Noshadi, I. https://doi.org/10.1021/acsami.5c08239 DANSE: a pipeline for dynamic modelling of time-series multi-omics data (2025) [Working paper › Preprint] . bioRxiv . Klomp, L. F. J. , Yan, X. , Snabel, R. R. , Veenstra, G. J. C. , Meijer, H. G. E. & Post, J. N. https://doi.org/10.1101/2025.07.04.663170 Enhancing organoid technology with carbon-based nanomaterial biosensors: Advancements, challenges, and future directions (2025) Advanced drug delivery reviews, 222 . Article 115592 . Rezaei, Z. , Wang, N. , Yang, Y. , Govindaraj, K. , Velasco, J. J. , Martinez Blanco, A. D. , Bae, N. H. , Lee, H. Y. & Shin, S. R. https://doi.org/10.1016/j.addr.2025.115592 Hierarchical engineering of modular tissues (2025) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Johnbosco, C. https://doi.org/10.3990/1.9789036567060 One-way self-expanding rods for early onset neuromuscular scoliosis: a two-year follow-up of an international cohort (2025) European spine journal, 34(7) , 2771-2780 . Post, A. M. , Gaume, M. , van Royen, B. J. , Janssen, E. , Lundine, K. , Johnson, M. , Neagoe, P. , Kruyt, M. , Boissiere, L. , Kaleeta Maalu, J. P. , Renkens, J. , Deml, M. C. , Stadhouder, A. , Solla, F. , Schaible, S. , Tabeling, C. , Mielenbrink, J. & Miladi, L. https://doi.org/10.1007/s00586-025-08884-z Spinal ultrasound to quantify in-brace correction before nighttime brace fabrication in adolescent idiopathic scoliosis (2025) European spine journal, 34(7) , 2646-2652 . van de Fliert, D. G. , Lafranca, P. P. G. , Arets, A. , van Loon, I. C. J. , Kruyt, M. C. , van Rhijn, L. W. , Castelein, R. M. & Schlösser, T. P. C. https://doi.org/10.1007/s00586-025-08916-8 Genetic Engineering of VHH Antibody Fragments for Efficient Site-Specific Conjugation to Polysaccharides (2025) Bioconjugate chemistry, 36(6) , 1319-1328 . Zhong, L. , Morshuis, L. C. M. , Koerselman, M. , Memelink, A. , Kolecka, A. , Heukers, R. , Verrips, T. , Karperien, M. & Zoetebier, B. https://doi.org/10.1021/acs.bioconjchem.5c00167 VHHs as disease modifying therapeutics for osteoarthritis (2025) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Morshuis, L. C. M. https://doi.org/10.3990/1.9789036566438 The Joint-on-Chip: A multi-Organ-on-Chip Model for Studying Inter-Tissue Crosstalk in Arthritis (2025) [Contribution to conference › Poster] 1st Dutch Osteoarthritis Research Day, OA Research Day NL . Spoelstra, L. R. , Semmekrot, F. R. , Serrano-Larrea, C. , Le, T. , Le Gac, S. , Segerink, L. & Karperien, M. Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model (2025) Journal of Cartilage & Joint Preservation, 5(2) . Article 100233 . Piluso, S. , Li, Y. , Texeira, L. M. , Padmanaban, P. , Rouwkema, J. , Leijten, J. , van Weeren, R. , Karperien, M. & Malda, J. https://doi.org/10.1016/j.jcjp.2025.100233 Research Progress on the Application of Neutralizing Nanobodies in the Prevention and Treatment of Viral Infections (2025) Microorganisms, 13(6) . Article 1352 . Duan, Q. , Ai, T. , Ma, Y. , Li, R. , Jin, H. , Chen, X. , Zhang, R. , Bao, K. & Chen, Q. https://doi.org/10.3390/microorganisms13061352 Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation (2025) Materials Today Bio, 32 . Article 101728 . Pereira Dos Santos Conceição, F. , Meneses, J. , Lebre, F. , Becker, M. , Araújo-Gomes, N. , Vos, R. , Ribeiro, A. R. , Alfaro-Moreno, E. , Leijten, J. & Moreira Teixeira, L. https://doi.org/10.1016/j.mtbio.2025.101728 Molecular profiling of oxygen's impact on chondrocytes: Insights from mass spectrometry imaging (2025) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Bakker, B. https://doi.org/10.3990/1.9789036565783 Mixtures of PRR Ligands Partly Mimic the Immunomodulatory Response of γi Staphylococcus aureus, Enhancing Osteogenic Differentiation of Human Mesenchymal Stromal Cells (2025) Stem cells international, 2025(1) . Article 1445520 (E-pub ahead of print/First online) . Khokhani, P. , Warmink, K. , Kruyt, M. , Weinans, H. & Gawlitta, D. https://doi.org/10.1155/sci/1445520 Incorporating Microbial Stimuli for Osteogenesis in a Rabbit Posterolateral Spinal Fusion Model (2025) Tissue engineering. Part A, 31(9-10) , 387-397 . Rahmani, N. R. , Duits, A. , Croes, M. , Lock, O. , Gawlitta, D. , Weinans, H. & Kruyt, M. C. https://doi.org/10.1089/ten.tea.2024.0064 Local delivery of lipid-based nanoparticles containing microbial nucleic acid for osteoimmunomodulation (2025) European journal of pharmaceutical sciences, 208 . Article 107050 . Rahmani, N. R. , Jahanmard, F. , Hassani Najafabadi, A. , Flapper, J. , Dogan, O. , Khodaei, A. , Storm, G. , Croes, M. , Kruyt, M. C. , Gawlitta, D. , Weinans, H. , Mastrobattista, E. & Amin Yavari, S. https://doi.org/10.1016/j.ejps.2025.107050 Covalent On-Cell Conjugation of Biomaterials Through Oxidative Phenolic Coupling Regulates Stem Cell Fate via Intracellular Biophysical Programming (2025) Advanced functional materials, 35(17) . Article 2418963 . Johnbosco, C. , Becker, M. , Willemen, N. , Meteling, M. , Govindaraj, K. , Kamperman, T. & Leijten, J. https://doi.org/10.1002/adfm.202418963 MODELING CARTILAGE FATE: ADVANCING OA TREATMENTS AND CHONDROCYTE DIFFERENTIATION (2025) Osteoarthritis and cartilage, 33(Supplement) , S108 . Klomp, L. J. , Schivo, S. , Kannan, S. , Meijer, H. & Post, J. https://doi.org/10.1016/j.joca.2025.02.146 Topography of genuine sex-differences in femorotibial cartilage thickness (2025) Osteoarthritis and cartilage, 33(Supplement) , S305-S306 . Spoelder, N. , Wirth, W. , Turmezei, T. , Eckstein, F. , Kessler, D. A. , Mackay, J. W. , Karperien, M. , Mastbergen, S. & Jansen, M. P. https://doi.org/10.1016/j.joca.2025.02.428 The Modified Canine Groove Model of Osteoarthritis † (2025) Biomedicines, 13(4) . Article 913 . van der Weiden, G. S. , Meij, B. P. , van de Belt, A. , Custers, R. J. H. , Both, S. K. , Karperien, M. & Mastbergen, S. C. https://doi.org/10.3390/biomedicines13040913 673 - Replate: a multi-compression cartilage-on-chip model for medium-trhoughput mechano-response assessment (2025) Osteoarthritis and cartilage, 33 , S464-S465 . Paggi, C. A. , Semmekrot, F. , Lauwers, E. , Le, T. , Larrea, C. S. & Karperien, M. https://doi.org/10.1016/j.joca.2025.02.681 A multi-tissue model to investigate synovial membrane and cartilage crosstalk (2025) Osteoarthritis and cartilage, 33(Supplement) , S84-S85 . Paggi, C. A. , Lauwers, E. , Dopsa, D. & Karperien, M. https://doi.org/10.1016/j.joca.2025.02.117 ATPS-enabled single-step printing of chemically and mechanically on-demand tunable perfusable channels in ejectable constructs (2025) Biofabrication, 17(2) . Article 025027 . Becker, M. , Gomes, F. , Porsul, I. & Leijten, J. https://doi.org/10.1088/1758-5090/adbcdc Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages (2025) Acta Pharmaceutica Sinica B, 15(4) , 2114-2133 . Geervliet, E. , Arora, S. , Donohue, D. , de Albuquerque Pinheiro, C. A. , Terstappen, L. W. M. M. , Schasfoort, R. , Paez, J. , Kumar, R. & Bansal, R. https://doi.org/10.1016/j.apsb.2025.02.018 Hydrogel-Based Bioinks for Coaxial and Triaxial Bioprinting: A Review of Material Properties, Printing Techniques, and Applications (2025) Polymers, 17(7) . Article 917 . Banigo, A. T. , Nauta, L. , Zoetebier, B. & Karperien, M. https://doi.org/10.3390/polym17070917 Engineering synthetic erythrocytes for blood substitution (2025) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Fernandes Gomes, F. L. https://doi.org/10.3990/1.9789036565226 OPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility (2025) ACS Applied Materials & Interfaces, 17(12) , 18179-18193 . Fernandes Gomes, F. L. , Wasserberg, D. , Edelbroek, R. , van Weerd, J. , Jonkheijm, P. & Leijten, J. https://doi.org/10.1021/acsami.5c02103 High-Throughput Single-Cell Analysis of Local Nascent Protein Deposition in 3D Microenvironments via Extracellular Protein Identification Cytometry (EPIC) (2025) Advanced materials, 37(6) . Article 2415981 . Meteling, M. , Johnbosco, C. , Wolfel, A. , Conceição, F. , Govindaraj, K. , Teixeira, L. M. & Leijten, J. https://doi.org/10.1002/adma.202415981 High‐Throughput Single‐Cell Analysis of Local Nascent Protein Deposition in 3D Microenvironments via Extracellular Protein Identification Cytometry (EPIC) (Adv. Mater. 6/2025): Graphical Abstract (2025) Advanced materials, 37(6) . Meteling, M. , Johnbosco, C. , Wolfel, A. , Conceição, F. , Govindaraj, K. , Moreira Teixeira, L. & Leijten, J. https://doi.org/10.1002/adma.202570044 Pelvic osteotomies for correction of sagittal imbalance of the spine: An in-silico study comparing four different osteotomies (2025) Annals of 3D Printed Medicine, 17 . Article 100185 . Ochtman, A. E. A. , Claessens, M. J. , Öner, F. C. , Schlösser, T. P. C. , Willemsen, K. , Magré, J. , Nguyen, H. C. & Kruyt, M. C. https://doi.org/10.1016/j.stlm.2024.100185 Injectable hydrogels for cartilage tissue engineering: key design needs toward clinical applications (2025) Academia Biology, 3(1) . Banigo, A. T. , Nwekwo, A. , Zoetebier, B. & Karperien, M. https://doi.org/10.20935/AcadBiol7512 Synergistic effect of Hypoxic Conditioning and Cell-Tethering Colloidal Gels enhanced Productivity of MSC Paracrine Factors and Accelerated Vessel Regeneration (2025) Advanced materials, 37(3) . Article 2408488 . Lee, M. C. , Lee, J. S. , Kim, S. , Jamaiyar, A. , Wu, W. , Gonzalez, M. L. , Durán, T. C. A. , Madrigal-Salazar, A. D. , Bassous, N. , Carvalho, V. , Choi, C. , Kim, D. S. , Seo, J. W. , Rodrigues, N. , Teixeira, S. F. C. F. , Alkhateeb, A. F. , Soto, J. A. L. , Hussain, M. A. , Leijten, J. , … Shin, S. R. https://doi.org/10.1002/adma.202408488 Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration (2025) Pharmaceutics, 17(1) . Article 64 . Gomes, F. L. , Conceição, F. , Teixeira, L. M. , Leijten, J. & Jonkheijm, P. https://doi.org/10.3390/pharmaceutics17010064 Synergistic effect of Hypoxic Conditioning and Cell‐Tethering Colloidal Gels enhanced Productivity of MSC Paracrine Factors and Accelerated Vessel Regeneration (Adv. Mater. 3/2025): Graphical Abstract (2025) Advanced materials, 37(3) . Lee, M. C. , Lee, J. S. , Kim, S. , Jamaiyar, A. , Wu, W. , Gonzalez, M. L. , Durán, T. C. 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2019
3D Printed Cartilage-Like Tissue Constructs with Spatially Controlled Mechanical Properties (2019) Advanced functional materials, 29(51) . Article 1906330 . de Melo, B. A. G. , Jodat, Y. A. , Mehrotra, S. , Calabrese, M. A. , Kamperman, T. , Mandal, B. B. , Santana, M. H. A. , Alsberg, E. , Leijten, J. & Ryon Shin, S. https://doi.org/10.1002/adfm.201906330 Ezh2 inhibition primes BMP2-mediated osteogenic differentiation and bone healing (2019) Journal of bone and mineral research, 34(S1) , 229-229 . Article SUN-468 . Dudakovic, A. , Samsonraj, R. , Paradise, C. , Galeano-Garces, C. , Mol, M. , Galeano-Garces, D. , Galvan, M. L. , Thaler, R. , Larson, A. N. , Westendorf, J. , van Wijnen, A. , Zan, P. , Begun, D. , Kloen, P. & Karperien, M. https://doi.org/10.1002/jbmr.3936 Meniscus regeneration combining meniscus and mesenchymal stromal cells in a degradable meniscus implant: An in vitro study (2019) European cells & materials, 38 , 51-62 . Hagmeijer, M. H. , Vonk, L. 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Karperien, M. https://doi.org/10.1136/annrheumdis-2019-eular.8511 Secondary Meniscal Tears in Patients With Anterior Cruciate Ligament Injury: Relationship Among Operative Management, Osteoarthritis, and Arthroplasty at 18-Year Mean Follow-up (2019) The American journal of sports medicine, 47(7) , 1583-1590 . Hagmeijer, M. H. , Hevesi, M. , Desai, V. S. , Sanders, T. L. , Camp, C. L. , Hewett, T. E. , Stuart, M. J. , Saris, D. B. F. & Krych, A. J. https://doi.org/10.1177/0363546519844481 What Controls Endothelial Sprouting?: Interstitial Flow vs. Shear Stress (2019) [Contribution to conference › Abstract] TERMIS European Chapter Meeting 2019 . Salehi Nik, N. , Sayedipour, S. S. , Padmanaban, P. , Stein, F. & Rouwkema, J. A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model (2019) Tissue engineering. Part C: Methods, 25(4) , 191-196 . Hevesi, M. , Crispim, J. F. , Paggi, C. A. , Dudakovic, A. , van Genechten, W. , Hewett, T. 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Moreira Teixeira, L. , Paggi, C. , Piluso, S. , Leijten, J. , Malda, J. , van Weeren, R. , le Gac, S. & Karperien, M. An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells (2019) Acta biomaterialia, 83 , 233-244 . Jooybar, E. , Abdekhodaie, M. J. , Alvi, M. , Karperien, M. & Dijkstra, P. J. https://doi.org/10.1016/j.actbio.2018.10.031 Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 406-407) . The Chemical and Biological Microsystems Society . Paggi, C. A. , Venzac, B. , Leijten, J. , Leijten, L. M. T. , Karperien, M. & Le Gac, S. 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K. , Coeleveld, K. , Zoetebier, B. , Leijten, J. , Weinans, H. & Karperien, H. B. J. Spatiotemporal biomaterial functionalization via competitive supramolecular complexation of avidin and biotin analogs (2019) [Contribution to conference › Abstract] TERMIS European Chapter Meeting 2019 . Kamperman, T. , Koerselman, M. , Kelder, C. , Hendriks, J. , Crispim, J. F. , de Peuter, X. , Dijkstra, P. J. , Karperien, M. & Leijten, J.
2018
Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affectcartilage development (2018) Journal of biological chemistry, 293 , 19001-19011 . Camilleri, E. T. , Dudakovic, A. , Riester, S. M. , Galeano Garces, C. , Paradise, C. R. , Bradley, E. W. , McGee-Lawrence, M. E. , Im, H.-J. , Karperien, M. , Krych, A. J. , Westendorf, J. J. , Larson, A. N. & van Wijnen, A. J. https://doi.org/10.1074/jbc.RA118.003909 Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments (2018) Scientific reports, 8(1) . Article 10251 . Huang, X. , Zhong, L. , Post, J. N. & Karperien, M. https://doi.org/10.1038/s41598-018-27602-y Surgical Feasibility of a One-Stage Cell-Based Arthroscopic Procedure for Meniscus Regeneration: A Cadaveric Study (2018) Tissue engineering. Part C: Methods, 24(12) , 688-696 . Hagmeijer, M. H. , Vonk, L. A. , Kouwenhoven, J.-W. , Custers, R. J. H. , Bleys, R. L. , Krych, A. J. & Saris, D. B. F. https://doi.org/10.1089/ten.tec.2018.0240 Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells (2018) Tissue engineering. Part C: Methods, 24(11) , 628-636 . Hadavi, E. , Leijten, J. , Brinkmann, J. , Jonkheijm, P. , Karperien, M. & van Apeldoorn, A. https://doi.org/10.1089/ten.TEC.2018.0151 Mimicking articular motion in a cartilage-on-a-chip model (2018) [Contribution to conference › Poster] 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 . Paggi, C. A. , Venzac, B. , Leijten, J. & le Gac, S. An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes (2018) Journal of Materials Science: Materials in Medicine, 29(11) . Article 174 . Groot Nibbelink, M. , Skrzypek, K. , Karbaat, L. , Both, S. , Plass, J. , Klomphaar, B. , van Lente, J. , Henke, S. , Karperien, M. , Stamatialis, D. & van Apeldoorn, A. https://doi.org/10.1007/s10856-018-6178-6 Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling (2018) Heart Rhythm, 15(11) , 1708-1716 . Meijering, R. A. M. , Wiersma, M. , Zhang, D. , Lanters, E. A. H. , Hoogstra-Berends, F. , Scholma, J. , Diks, S. , Qi, X. Y. , de Groot, N. M. S. , Nattel, S. , Henning, R. H. & Brundel, B. J. J. M. https://doi.org/10.1016/j.hrthm.2018.06.014 A cartilage-on-a-chip platform recapitulating joint motion (2018) [Contribution to conference › Poster] NanoBioTech Montreux 2018 . Paggi, C. A. , Venzac, B. , Leijten, J. & le Gac, S. Bioactive Tape With BMP-2 Binding Peptides Captures Endogenous Growth Factors and Accelerates Healing After Anterior Cruciate Ligament Reconstruction (2018) The American journal of sports medicine, 46(12) , 2905-2914 . Crispim, J. F. , Fu, S. C. , Lee, Y. W. , Fernandes, H. A. M. , Jonkheijm, P. , Yung, P. S. H. & Saris, D. B. F. https://doi.org/10.1177/0363546518787507 Molecular characterization of physis tissue by RNA sequencing (2018) Gene, 668 , 87-96 . Paradise, C. R. , Galeano-Garces, C. , Galeano-Garces, D. , Dudakovic, A. , Milbrandt, T. A. , Saris, D. B. F. , Krych, A. J. , Karperien, M. , Ferguson, G. B. , Evseenko, D. , Riester, S. M. , van Wijnen, A. J. & Noelle Larson, A. https://doi.org/10.1016/j.gene.2018.05.034 Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice (2018) Journal of biological chemistry, 293(33) , 12894-12907 . Dudakovic, A. , Camilleri, E. T. , Paradise, C. R. , Samsonraj, R. M. , Gluscevic, M. , Paggi, C. A. , Begun, D. L. , Khani, F. , Pichurin, O. , Ahmed, F. S. , Elsayed, R. , Elsalanty, M. , McGee-Lawrence, M. E. , Karperien, M. , Riester, S. M. , Thaler, R. , Westendorf, J. J. & van Wijnen, A. J. https://doi.org/10.1074/jbc.RA118.002983 Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6 (2018) Langmuir, 34(31) , 9298-9306 . Cabanas-Danés, J. , Landman, E. , Huskens, J. , Karperien, M. & Jonkheijm, P. https://doi.org/10.1021/acs.langmuir.8b00853 Single-Cell Microgels: Technology, Challenges, and Applications (2018) Trends in biotechnology, 36(8) , 850-865 . Kamperman, T. , Karperien, M. , Le Gac, S. & Leijten, J. https://doi.org/10.1016/j.tibtech.2018.03.001 Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics (2018) ACS Applied Materials & Interfaces, 10(28) , 23433-23438 . Kamperman, T. , Trikalitis, V. D. , Karperien, M. , Visser, C. W. & Leijten, J. https://doi.org/10.1021/acsami.8b05227 Synthesis of Hyaluronic acid-Tyramine Microgels for Sustained Protein Release (2018) In 2018 25th Iranian Conference on Biomedical Engineering and 2018 3rd International Iranian Conference on Biomedical Engineering, ICBME 2018 . Article 8703588 (2018 25th Iranian Conference on Biomedical Engineering and 2018 3rd International Iranian Conference on Biomedical Engineering, ICBME 2018) . IEEE . Jooybar, E. , Abdekhodaie, M. J. & Dijkstra, P. J. https://doi.org/10.1109/ICBME.2018.8703588 An important step towards a prevascularized islet macroencapsulation device: Effect of micropatterned membranes on development of endothelial cell network (2018) Journal of Materials Science: Materials in Medicine, 29(7) . Article 91 . Skrzypek, K. , Nibbelink, M. G. , Karbaat, L. P. , Karperien, M. , van Apeldoorn, A. & Stamatialis, D. https://doi.org/10.1007/s10856-018-6102-0 Detection of early cartilage damage: feasibility and potential of gagCEST imaging at 7T (2018) European radiology, 28(7) , 2874-2881 . Brinkhof, S. , Nizak, R. , Khlebnikov, V. , Prompers, J. J. , Klomp, D. W. J. & Saris, D. B. F. https://doi.org/10.1007/s00330-017-5277-y Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging (2018) Analytical chemistry, 90(11) , 6563-6571 . Hendriks, J. , Stojanovic, I. , Schasfoort, R. B. M. , Saris, D. B. F. & Karperien, M. https://doi.org/10.1021/acs.analchem.8b00260 Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis (2018) Osteoarthritis and cartilage, 26(6) , 834-843 . Huang, X. , Post, J. N. , Zhong, L. , Leijten, J. , Larsson, S. , Karperien, M. & Struglics, A. https://doi.org/10.1016/j.joca.2018.02.904 Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture Five-Year Follow-up of a Prospective Randomized Trial (2018) The American journal of sports medicine, 46(6) , 1343-1351 . Brittberg, M. , Recker, D. , Ilgenfritz, J. & Saris, D. B. F. https://doi.org/10.1177/0363546518756976 Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions (2018) ACS Applied Materials & Interfaces, 10(16) , 13293-13303 . Seo, J. , Shin, J. Y. , Leijten, J. , Jeon, O. , Bal Öztürk, A. , Rouwkema, J. , Li, Y. , Ryon Shin, S. , Hajiali, H. , Alsberg, E. & Khademhosseini, A. https://doi.org/10.1021/acsami.7b17991 A new method for multiplex measurements of biomarkers in synovial fluid aspirates with high sensitivity and extensive quality control (2018) Osteoarthritis and cartilage, 26(supplement 1) , S193-S193 . Article 374 . Hendriks, J. , Saris, D. & Karperien, M. https://doi.org/10.1016/j.joca.2018.02.413 Mitochondrial changes of articular chondrocytes revealed by omics analyses (2018) Osteoarthritis and cartilage, 26(supplement 1) , S170-S171 . Article 332 . Bakker, B. , Eijkel, G. , Mohren, R. , Heeren, R. , Karperien, M. , Post, J. & Cillero-Pastor, B. https://doi.org/10.1016/j.joca.2018.02.370 SOX9 transcriptional activity is differentially regulated in healthy and osteoarthritic chondrocytes (2018) Osteoarthritis and cartilage, 26(suppl. 1) , S106-S107 . Article 195 . 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Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macrenvironments (2017) Advanced healthcare materials, 6(3) . Article 1600913 . Kamperman, T. , Henke, S. J. , van den Berg, A. , Shin, S. R. , Tamayol, A. , Khademhosseini, A. , Karperien, H. B. J. & Leijten, J. C. H. https://doi.org/10.1002/adhm.201600913 Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization (2017) Journal of Materials Science: Materials in Medicine, 28(12) . Article 195 . Marchioli, G. , Zellner, L. , Oliveira, C. , Engelse, M. , de Koning, E. , Mano, J. F. , Karperien, M. , Apeldoorn, A. v. & Moroni, L. https://doi.org/10.1007/s10856-017-6004-6 Pancreatic islet macroencapsulation using microwell porous membranes (2017) Scientific reports, 7(1) . Article 9186 . Skrzypek, K. , Groot Nibbelink, M. , van Lente, J. , Buitinga, M. , Engelse, M. A. , de Koning, E. J. 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N. https://doi.org/10.1016/j.joca.2016.01.339 Dextran (2016) In Biomaterials from Nature for Advanced Devices and Therapies (pp. 307-319) . Wiley . Wang, R. , Dijkstra, P. J. & Karperien, M. https://doi.org/10.1002/9781119126218.ch18 From the printer: Potential of three-dimensional printing for orthopaedic applications (2016) Journal of orthopaedic translation, 6 , 42-49 . Mok, S.-W. , Nizak, R. , Fu, S.-C. , Ho, K.-W. K. , Qin, L. , Saris, D. B. F. , Chan, K.-M. & Malda, J. https://doi.org/10.1016/j.jot.2016.04.003 Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production (2016) Stem cell research & therapy, 7(1) , 1-16 . Article 107 . Camilleri, E. T. , Gustafson, M. P. , Dudakovic, A. , Riester, S. M. , Garces, C. G. , Paradise, C. R. , Takai, H. , Karperien, M. , Cool, S. , Sampen, H. J. I. , Larson, A. N. , Qu, W. , Smith, J. , Dietz, A. B. & van Wijnen, A. J. https://doi.org/10.1186/s13287-016-0370-8 In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications (2016) Biomicrofluidics, 10(1) . Article 011501 . Lajoinie, G. , De Cock, I. , Coussios, C. C. , Lentacker, I. , le Gac, S. , Stride, E. & Versluis, M. https://doi.org/10.1063/1.4940429 In-air microfluidics for chip-free generation of microdroplets, -particles, -fibers, and 3D hierarchical prints (2016) In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 79-80) . The Chemical and Biological Microsystems Society . Kamperman, T. , Visser, C. W. , Leijten, J. , Lohse, D. & Karperien, M. Injectable enzymatically cross linkable hydrogels: a minimally invasive cell free approach to regenerate chondral defects (2016) Osteoarthritis and cartilage, 24(Suppl. 1) , S161-S161 . Both, S. , de Cockelaere, S. , Wang, R. , Vos, N. , Li, G. , Lin, Y. , van Weeren, R. , Dijkstra, P. & Karperien, M. https://doi.org/10.1016/j.joca.2016.01.317 Method and apparatus for in-air production of single droplets, compound droplets, and shape-controlled (compound) particles or fibers (2016) [Patent › Patent] (In preparation) . Visser, C. W. , Kamperman, T. , Karperien, H. B. J. & Lohse, D. Monovalent cation selective crown ether containing poly(arylene ether ketone)/SPEEK blend membranes (2016) RSC advances, 6 , 55635-55642 . Tas, S. , Zoetebier, B. , Hempenius, M. A. , Vancso, G. J. & Nijmeijer, K. https://doi.org/10.1039/c6ra11566g Nanocellular polymer foams nucleated by core-shell nanoparticles (2016) Polymer, 104 , 22-30 . Liu, S. , Zoetebier, B. , Hulsman, L. , Zhang, Y. , Duvigneau, J. & Vancso, G. J. https://doi.org/10.1016/j.polymer.2016.09.016 Oxygen regulates lipid profiles in human primary chondrocyte cultures (2016) Osteoarthritis and cartilage, 24(supplement 1) , S456-S457 . Article 779 . Bakker, B. , Eijkel, G. B. , Heeren, R. M. A. , Karperien, M. , Post, J. N. & Cillero Pastor, B. https://doi.org/10.1016/j.joca.2016.01.833 PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery (2016) Chemical communications, 52(49) , 7707-7710 . Zoetebier, B. , Sohrabi, A. , Lou, B. , Hempenius, M. A. , Hennink, W. E. & Vancso, G. J. https://doi.org/10.1039/C6CC02733D Stamcellen. Wetenschap, werkelijkheid en fictie (2016) [Book/Report › Book] . Stichting Bio-Wetenschappen en Maatschappij . Karperien, H. B. J. & Mummery, C. L. http://www.biomaatschappij.nl/product/stamcellen-2/ The matrix reloaded: the evolution of regenerative hydrogels (2016) Materials Today Bio, 19(4) , 190-196 . Jabbari, E. , Leijten, J. C. H. , Xu, Q. & Khademhosseini, A. https://doi.org/10.1016/j.mattod.2015.10.005 The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes (2016) Gene, 591(2) , 456-464 . Lewallen, E. A. , Bonin, C. A. , Li, X. , Smith, J. , Karperien, H. B. J. , Larson, A. N. , Lewallen, D. G. , Cool, S. M. , Westendorf, J. J. , Krych, A. J. , Leontovich, A. A. , Im, H.-J. & Wijnen, van, A. J. https://doi.org/10.1016/j.gene.2016.06.063 Weefselregeneratie en tissue-engineering (2016) In Stamcellen: wetenschap, werkelijkheid en fictie (pp. 31-35) (Cahier biowetenschappen en maatschappij) . Stichting BWM . Karperien, H. B. J. http://www.biomaatschappij.nl/wordpress/wp-content/uploads/2016/06/BWM_Stamcellen_72dpi.pdf ‘CTA-Lite’ for Exploring Possible Innovation Pathways of a Nanomedicine-Related Platform–Embedded Responsible Research and Innovation in Practice (2016) In Responsibility and Emerging Technologies: Experiences, Education and Beyond (pp. 25-42) (Studies of New and Emerging Technologies; Vol. 7) . IOS . Schulze Greiving, V. C. , Konrad, K. , Robinson, D. K. R. & le Gac, S.
2015
Injectable enzymatically cross linkable hydrogels: a minimally invasive cell free approach to regenerate chondral defects (2015) [Contribution to conference › Abstract] Go Life 2015 . Both, S. K. , de Cockelaere, S. , Wang, R. , Vos, N. J. , Li, G. , Lin, Y. , van Weeren, R. , Dijkstra, P. J. & Karperien, M. Supporting data of spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo (2015) Data in brief, 5 , 84-94 . Higuera Sierra, G. , Fernandes, H. , Spitters, T. , van de Peppel, J. , Auffermann, N. , Truckenmüller, R. , Escalante, M. , Stoop, R. , van Leeuwen, J. P. , de Boer, J. , Subramaniam, V. , Karperien, M. , van Blitterswijk, C. , van Boxtel, A. & Moroni, L. https://doi.org/10.1016/j.dib.2015.08.012 Process for the preparation of an object supporting a lipid layer (2015) [Patent › Patent] (Submitted) . van Weerd, J. , Karperien, H. B. J. & Jonkheijm, P. Supported Lipid Bilayers for the Generation of Dynamic Cell–Material Interfaces (2015) Advanced healthcare materials, 4(18) , 2743-2779 . van Weerd, J. , Karperien, H. B. J. & Jonkheijm, P. https://doi.org/10.1002/adhm.201500398 Biological evaluation of porous aliphatic polyurethane/hydroxyapatite composite scaffolds for bone tissue engineering. (2015) Journal of biomedical materials research. Part A, 103(7) , 2251-2259 . Yang, W. , Both, S. K. , Zuo, Y. , Tahmasebi Birgani, Z. , Habibovic, P. , Jansen, J. A. & Yang, F. https://doi.org/10.1002/jbm.a.35365 Differentiation capacity and maintenance of differentiated phenotypes of human mesenchymal stromal cells cultured on two distinct types of 3D polymeric scaffolds (2015) Integrative biology, 7(12) , 1574-1586 . Leferink, A. M. , Santos, D. , Karperien, M. , Truckenmüller, R. K. , van Blitterswijk, C. A. & Moroni, L. https://doi.org/10.1039/c5ib00177c Plan-β: a bioengineering approach against type 1 diabetes (2015) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Buitinga, M. https://doi.org/10.3990/1.9789462330627 Photo-switchable distributors of light based on self-assembled monodisperse chiral nematic micropsheres (2015) In 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015) (pp. 3) (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2015) . The Chemical and Biological Microsystems Society . Asshoff, S. J. , Lancia, F. , Sukas, S. , Blonde, J.-B. , Yamaguchi, T. , Hommersom, C. A. , le Gac, S. & Katsonis, N. An orthotopic mouse model for chondrosarcoma of bone provides an in vivo tool for drug testing (2015) Virchows Archiv, 466(1) , 101-109 . van Oosterwijk, J. G. , Plass, J. R. M. , Meijer, D. , Que, I. , Karperien, M. & Bovée, J. V. M. G. https://doi.org/10.1007/s00428-014-1670-y Musculoskeletal regeneration research network: A global initiative (2015) Journal of orthopaedic translation, 3(4) , 160-165 . Chan, K. M. , Rolf, C. G. , Qin, L. , Felländer-Tsai, L. , Castelein, R. M. , Saris, D. B. F. , Malda, J. , Richards, G. , Goodman, S. B. , Tuan, R. S. , Maloney, W. , Lidgren, L. , Hopkins, C. , Fu, S. C. , Li, G. , Ding, M. , Tang, T. T. , Zhang, X. L. , Wei, L. , … Ouyang, H. W. https://doi.org/10.1016/j.jot.2015.08.007 Superstructures of chiral nematic microspheres as all-optical switchable distributors of light (2015) Scientific reports, 6 . Article 14183 . Asshoff, S. , Sukas, S. , Yamaguchi, T. , Hommersom, C. A. , Le Gac, S. & Katsonis, N. https://doi.org/10.1038/srep14183 Injectable hydrogel for cartilage repair (2015) [Contribution to conference › Abstract] Eurocell 2 meeting, Oswestry, Shropshire, United Kingdom . Both, S. K. , de Cockelaere, S. , Wang, R. , van Weeren, R. , Dijkstra, P. J. & Karperien, H. B. J. Enzymatically Crosslinked Polysaccharide Based Hydrogels as an Extracellular Matrix for Cartilage Tissue Engineering (2015) [Contribution to conference › Abstract] 14th Bayreuth Polymer Symposium, BPS 2015 . Wang, R. , Dijkstra, P. J. & Karperien, H. B. J. Stimulation of beta-cell function by extracellular matrix proteins (2015) [Contribution to conference › Abstract] TERMIS World Congress 2015 . Hadavi, E. , de Koning, E. J. P. , Karperien, H. B. J. , Jonkheijm, P. & van Apeldoorn, A. A. Cell-transfecting multilayered surfaces from poly(amido amine)s (2015) Journal of controlled release, 213 , e58-e59 . Hujaya, S. D. , Marchioli, G. , Apeldoorn, A. A. v. , Paulusse, J. M. J. , Karperien, M. & Engbersen, J. F. J. https://doi.org/10.1016/j.jconrel.2015.05.096 Progress and future of in vitro models to study translocation of nanoparticles (2015) Archives of toxicology, 89(9) , 1469-1495 . Braakhuis, H. M. , Kloet, S. K. , Kezic, S. , Kuper, F. , Park, M. V. D. Z. , le Gac, S. , Krystek, P. , Peters, R. J. B. , Rietjens, I. M. C. M. & Bouwmeester, H. https://doi.org/10.1007/s00204-015-1518-5 Kinetically stable metal ligand charge transfer complexes as crosslinks in nanogels/hydrogels: Physical properties and cytotoxicity (2015) Acta biomaterialia, 26 , 136-144 . Wang, R. , Both, S. K. , Geven, M. , Calucci, L. , Forte, C. , Dijkstra, P. J. & Karperien, M. https://doi.org/10.1016/j.actbio.2015.08.019 MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors (2015) Stem cells and development, 24(16) , 1946-1955 . Georgi, N. , Taipaleenmaki, H. , Raiss, C. C. , Groen, N. , Portalska, K. J. , van Blitterswijk, C. , de Boer, J. , Post, J. N. , van Wijnen, A. J. & Karperien, M. https://doi.org/10.1089/scd.2014.0534 The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes (2015) International journal of molecular sciences, 16(8) , 19225-19247 . Zhong, L. , Huang, X. , Karperien, H. B. J. & Post, J. N. https://doi.org/10.3390/ijms160819225 Direct Cell–Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis (2015) Tissue engineering. Part A, 21(19/20) , 2536-2547 . de Windt, T. S. , Saris, D. B. F. , Slaper-Cortenbach, I. C. M. , van Rijen, M. H. P. , Gawlitta, D. , Creemers, L. B. , de Weger, R. A. , Dhert, W. J. A. & Vonk, L. A. https://doi.org/10.1089/ten.tea.2014.0673 Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo (2015) Biomaterials, 61 , 190-202 . Higuera, G. A. , Fernandes, H. , Spitters, T. W. G. M. , van de Peppel, J. , Auffermann, N. , Truckenmüller, R. , Escalante, M. , Stoop, R. , van Leeuwen, J. P. , de Boer, J. , Subramaniam, V. , Karperien, M. , van Blitterswijk, C. , van Boxtel, A. & Moroni, L. https://doi.org/10.1016/j.biomaterials.2015.05.017 Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation (2015) Biofabrication, 7(2) . Article 025009 . Marchioli, G. , van Gurp, L. , van Krieken, P. P. , Stamatialis, D. , Engelse, M. , van Blitterswijk, C. , Karperien, H. B. J. , de Koning, E. , Alblas, J. , Moroni, L. & van Apeldoorn, A. A. https://doi.org/10.1088/1758-5090/7/2/025009 Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review (2015) Stem cell research & therapy, 6 . Article 94 . Vonk, L. A. , de Windt, T. S. , Slaper-Cortenbach, I. C. M. & Saris, D. B. F. https://doi.org/10.1186/s13287-015-0086-1 Bone forming capacity of cell- and growth factor-based constructs at different ectopic implantation sites. (2015) Journal of biomedical materials research. Part A, 103(2) , 439-450 . Ma, K. , Yang, F. , Both, S. K. , Prins, H. J. , Helder, M. N. , Pan, J. , Cui, F. Z. , Jansen, J. A. & van den Beucken, J. J. https://doi.org/10.1002/jbm.a.35192 High-Throughput Screening Assay for the Identification of Compounds Enhancing Collagenous Extracellular Matrix Production by ATDC5 Cells (2015) Tissue engineering. Part C: Methods, 21(7) , 726-736 . le Bach, Q. , Fernandes, H. , Bouten, C. V. C. , Karperien, H. B. J. , van Blitterswijk, C. & de Boer, J. https://doi.org/10.1089/ten.tec.2014.0088 Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis (2015) Analytical chemistry, 87(7) , 3981-3988 . Georgi, N. , Cillero-Pastor, B. , Eijkel, G. B. , Periyasamy, P. C. , Kiss, A. , van Blitterswijk, C. , Post, J. N. , Heeren, R. M. A. & Karperien, M. https://doi.org/10.1021/acs.analchem.5b00114 Synovial fluid concentration of Gremlin1 but not frizzled-related protein is increased in patients after acute knee injury (2015) [Contribution to conference › Abstract] 2015 OARSI World Congress on Osteoarthritis . Zhong, L. , Leijten, J. C. H. , Post, J. N. , Larsson, S. , Karperien, H. B. J. & Struglics, A. Injectable hydrogel for cartilage repair (2015) [Contribution to conference › Abstract] Health Valley, Nijmegen, Netherlands . Both, S. K. , Wang, R. , Dijkstra, P. J. & Karperien, H. B. J. Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets (2015) Journal of cellular and molecular medicine, 19(8) , 1836-1846 . Hilderink, J. , Spijker, S. , Carlotti, F. , Lange, L. , Engelse, M. , van Blitterswijk, C. , de Koning, E. , Karperien, M. & van Apeldoorn, A. A. https://doi.org/10.1111/jcmm.12555 The influence of process parameters on the properties of electrospun PLLA yarns studied by the response surface methodology (2015) Journal of applied polymer science, 132(5) . Article 41388 . Maleki, H. , Gharehaghaji, A. A. , Criscenti, G. , Moroni, L. & Dijkstra, P. J. https://doi.org/10.1002/app.41388 Osteogenic capacity of human BM-MSCs, AT-MSCs and their co-cultures using HUVECs in FBS and PL supplemented media. (2015) Journal of tissue engineering and regenerative medicine, 9(7) , 779-788 . Ma, K. , van den Beucken, J. J. , Both, S. K. , Prins, H. J. , Helder, M. N. , Yang, F. & Jansen, J. A. https://doi.org/10.1002/term.1704 Poly(amido amine)-based multilayered thin films on 2D and 3D supports for surface-mediated cell transfection (2015) Journal of controlled release, 205 , 181-189 . Hujaya, S. D. , Marchioli, G. , Roelofs, K. , van Apeldoorn, A. A. , Moroni, L. , Karperien, M. , Paulusse, J. M. J. & Engbersen, J. F. J. https://doi.org/10.1016/j.jconrel.2015.01.034 Novel biomedical applications of supported lipid bilayers (2015) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . van Weerd, J. https://doi.org/10.3990/1.9789036538268 Quantifying cell adhesion through impingement of a controlled microjet (2015) Biophysical journal, 108(1) , 23-31 . Visser, C. W. , Gielen, M. V. , Hao, Z. , le Gac, S. , Lohse, D. & Sun, C. https://doi.org/10.1016/j.bpj.2014.10.071 Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study (2015) Osteoarthritis and cartilage, 23(1) , 143-150 . de Windt, T. S. , Vonk, L. A. , Buskermolen, J. K. , Visser, J. , Karperien, M. , Bleys, R. L. A. W. , Dhert, W. J. A. & Saris, D. B. F. https://doi.org/10.1016/j.joca.2014.09.016 Cartilage Regeneration in the Head and Neck Area: Combination of Ear or Nasal Chondrocytes and Mesenchymal Stem Cells Improves Cartilage Production (2015) Plastic and reconstructive surgery, 136(6) , 762e-774e . Pleumeekers, M. M. , Nimeskern, L. , Koevoet, W. L. M. , Karperien, M. , Stok, K. S. & van Osch, G. J. V. M. https://doi.org/10.1097/PRS.0000000000001812 Designer Peptide (2015) [Patent › Patent] (In preparation) . Post, J. N. , Karperien, H. B. J. & Scholma, J. Engineering Cartilage Tissue by Pellet Coculture of Chondrocytes and Mesenchymal Stromal Cells (2015) In Osteoporosis and Osteoarthritis (pp. 31-41) (Methods in molecular biology; Vol. 1226) . Springer . Wu, L. , Post, J. N. & Karperien, H. B. J. https://doi.org/10.1007/978-1-4939-1619-1_4 In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction (2015) PLoS ONE, 10(12) , - . Article e0145240 . Steins, A. , Dik, P. , Müller, W. H. , Vervoort, S. J. , Reimers, K. , Kubhier, J. W. , Vogt, P. M. , van Apeldoorn, A. A. , Coffer, P. J. & Schepers, K. https://doi.org/10.1371/journal.pone.0145240 Optimizing cell viability in droplet-based cell deposition (2015) Scientific reports, 5 . Article 11304 . Hendriks, J. , Visser, C. W. , Henke, S. J. , Leijten, J. C. H. , Saris, D. B. F. , Sun, C. , Lohse, D. & Karperien, M. https://doi.org/10.1038/srep11304 Osteoarthritis treatment using autologous conditioned serum after placebo: Patient considerations and clinical response in a non-randomized case series (2015) Acta orthopaedica, 86(1) , 114-118 . Rutgers, M. , Creemers, L. B. , Yang, K. G. A. , Raijmakers, N. J. H. , Dhert, W. J. A. & Saris, D. B. F. https://doi.org/10.3109/17453674.2014.950467 Pain following primary total knee replacement: Causes, diagnosis and treatment (2015) Nederlands tijdschrift voor geneeskunde, 159(40) , - . Article A8445 . van Geene, A. R. , Saris, D. B. F. & Custers, R. J. H. https://www.ntvg.nl/artikelen/pijn-na-primaire-totale-knieprothese/artikelinfo Photo-switchable distributors of light based on self-assembled monodisperse chiral nematic microspheres (2015) In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 233-235) . The Chemical and Biological Microsystems Society . Asshoff, S. J. , Lancia, F. , Sukas, S. , Blondé, J. B. , Yamaguchi, T. , Hommersom, C. A. , Le Gac, S. & Katsonis, N. Photoacoustic imaging: Cells make themselves heard (2015) Nature photonics, 9 , 216-218 . Manohar, S. , van Apeldoorn, A. A. & Steenbergen, W. https://doi.org/10.1038/nphoton.2015.46 Photoresponsive Cucurbit[8]uril-Mediated Adhesion of Bacteria on Supported Lipid Bilayers (2015) Small, 11(46) , 6187-6196 . Sankaran, S. , van Weerd, J. , Voskuhl, J. , Karperien, M. & Jonkheijm, P. https://doi.org/10.1002/smll.201502471
2014
On-Chip Electrophoresis in Supported Lipid Bilayer Membranes Achieved Using Low Potentials (2014) Journal of the American Chemical Society, 136(1) , 100-103 . van Weerd, J. , Krabbenborg, S. , Eijkel, J. C. T. , Karperien, H. B. J. , Huskens, J. & Jonkheijm, P. https://doi.org/10.1021/ja411287u Droplet microfluidics for the encapsulation of beta-cells in microgels of natural polysaccharides conjugates (2014) [Contribution to conference › Abstract] 23rd NBTE Annual Meeting 2014 . Henke, S. J. , Leijten, J. C. H. , Kamperman, T. , Wang, R. , van den Berg, A. , Dijkstra, P. J. , van Apeldoorn, A. A. & Karperien, H. B. J. Hydrogels By Supramolecular Crosslinking Of Terpyridine End Group Functionalized 8-arm Poly(Ethylene Glycol) (2014) [Contribution to conference › Poster] 23rd NBTE Annual Meeting 2014 . Wang, R. , Dijkstra, P. J. & Karperien, H. B. J. Primary Chemical Sequence Ultimately Determines Crystal Thickness in Segmented All-Aliphatic Copolymers (2014) Macromolecules, 47(22) , 7890-7899 . Odarchenko, Y. I. , Anokhin, D. V. , Doblas, D. , Rosenthal, M. , Hernandez, J. J. , Vidal, L. , Sijbrandi, N. J. , Kimenai, A. J. , Mes, E. P. C. , Broos, R. , Bar, G. , Dijkstra, P. J. , Feijen, J. , Soloviev, M. & Ivanov, D. A. https://doi.org/10.1021/ma501545b Hydrogels By Supramolecular Crosslinking Of Terpyridine End Group Functionalized 8-arm Poly(Ethylene Glycol) (2014) [Contribution to conference › Abstract] NIRM 2014, Rotterdam, 29-30 October 2014 . Wang, R. , Dijkstra, P. J. & Karperien, H. B. J. Hydrogels By SupramolecularCrosslinking Of Terpyridine End Group Functionalized 8-Arm Poly(Ethylene Glycol) (2014) [Contribution to conference › Poster] NIRM 2014, Rotterdam, Netherlands . Wang, R. , Dijkstra, P. J. & Karperien, H. B. J. Microfluidic production of tissue engineered islets of Langerhans: microgel functionalization using biomimetic elements (2014) [Contribution to conference › Abstract] New Frontiers In Regenerative Medicine Symposium 2014, Nijmegen . Henke, S. J. , Leijten, J. C. H. , van den Berg, A. , Dijkstra, P. J. , van Apeldoorn, A. A. & Karperien, H. B. J. Boosting angiogenesis and functional vascularization in injectable dextran-hyaluronic acid hydrogels by endothelial-like mesenchymal stromal cells (2014) Tissue engineering. Part A, 20(3-4) , 819-829 . Janeczek Portalska, K. , Moreira Teixeira, L. , Leijten, J. C. H. , Jin, R. , van Blitterswijk, C. , de Boer, J. & Karperien, M. https://doi.org/10.1089/ten.TEA.2013.0280 Glucose Gradients Influence Zonal Matrix Deposition in 3D Cartilage Constructs (2014) Tissue engineering. Part A, 20(23-24) , 3270-3278 . Spitters, T. , Mota, C. M. D. , Uzoechi, S. C. , Slowinska, B. , Martens, D. E. , Moroni, L. & Karperien, H. B. J. https://doi.org/10.1089/ten.tea.2014.0059 Method for making a polymer, a polymer article, a biodevice, and cyclic carbonate (2014) [Patent › Patent] . Zhong, Z. , Meng, F. , Wang, R. & Feijen, J. Single domain antibodies in tissue engineering (2014) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Rodrigues, E. D. https://doi.org/10.3990/1.9789036537353 Locked-in Biomimetic Surface Gradients that are Tunable in Size, Density and Functionalization (2014) ChemPhysChem, 15(16) , 3460-3465 . Krabbenborg, S. , van Weerd, J. , Karperien, H. B. J. , Jonkheijm, P. & Huskens, J. https://doi.org/10.1002/cphc.201402509 ANIMO: a tool for modeling biological pathway dynamics (2014) [Contribution to conference › Abstract] TERMIS-EU Chapter Meeting 2014<br/> . Schivo, S. , Scholma, J. , Karperien, H. B. J. , Langerak, R. , van de Pol, J. C. & Post, J. N. https://doi.org/10.1002/term.1931 ECHO: the executable chondrocyte (2014) In Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting (pp. 54-54) (s1; Vol. 8) . Wiley . Scholma, J. , Schivo, S. , Kerkhofs, J. , Langerak, R. , Karperien, H. B. J. , van de Pol, J. C. , Geris, L. & Post, J. N. https://doi.org/10.1002/term.1931 Microfluidic production of enzymatically crosslinked Dextran-Tyramine microgels to improve type 1 diabetes therapies (2014) [Contribution to conference › Abstract] 1st international Conference on Micro & Nano Fluidics, FLOW 2014 . Henke, S. J. , Leijten, J. C. H. , Kemna, E. , van den Berg, A. , Dijkstra, P. J. , van Apeldoorn, A. A. & Karperien, H. B. J. Modeling Biological Pathway Dynamics With Timed Automata (2014) IEEE journal of biomedical and health informatics, 18(3) , 832-839 . Schivo, S. , Scholma, J. , Wanders, B. , Urquidi Camacho, R. A. , van der Vet, P. E. , Karperien, M. , Langerak, R. , van de Pol, J. & Post, J. N. https://doi.org/10.1109/JBHI.2013.2292880 DKK1 FRZB GREM1 Prevent IL1 Induced Articular Cartilage Degradation (2014) [Contribution to conference › Abstract] 2014 OARSI World Congress on Osteoarthritis . Zhong, L. , Karperien, H. B. J. & Post, J. N. Lipids as mediators of chondrogenesis (2014) [Contribution to conference › Abstract] 2014 OARSI World Congress on Osteoarthritis . Georgi, N. , Cillero Pastor, B. , Eijkel, G. , Periyasamy, P. C. , Kiss, A. , van Blitterswijk, C. , Post, J. N. , Heeren, R. M. A. & Karperien, H. B. J. https://doi.org/10.1016/j.joca.2014.02.104 Protein fibrils as scaffold material for cartilage tissue engineering - effects on cell viability and proliferation (2014) [Contribution to conference › Abstract] 2014 OARSI World Congress on Osteoarthritis . van Dalen, M. C. E. , Karperien, H. B. J. , Subramaniam, V. , Claessens, M. M. A. E. & Post, J. N. Setting Parameters for Biological Models With ANIMO (2014) In Proceedings 1st International Workshop on Synthesis of Continuous Parameters (pp. 35-47) (Electronic Proceedings in Theoretical Computer Science; Vol. 145) . Open Publishing Association . Schivo, S. , Scholma, J. , Karperien, H. B. J. , Post, J. N. , van de Pol, J. C. & Langerak, R. https://doi.org/10.4204/EPTCS.145.5 Setting Parameters for Biological Models With ANIMO (2014) [Working paper › Preprint] . ArXiv.org . Schivo, S. , Scholma, J. , Karperien, M. , Post, J. N. , van de Pol, J. & Langerak, R. https://doi.org/10.48550/arXiv.1404.0444 An echo in biology: validating the executable chondrocyte (2014) In 2014 World Congress on Osteoarthritis (pp. S157-S157) (Osteoarthritis and Cartilage; Vol. 22) . Elsevier . Scholma, J. , Schivo, S. , Karperien, H. B. J. , Langerak, R. , van de Pol, J. C. & Post, J. N. https://doi.org/10.1016/j.joca.2014.02.291 Mesenchymal Stromal/Stem Cell–or Chondrocyte-Seeded Microcarriers as Building Blocks for Cartilage Tissue Engineering (2014) Tissue engineering. Part A, 20(17-18) , 2513-2523 . Georgi, N. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.1089/ten.tea.2013.0681 Immuno-Protective Membrane-Based Scaffolds For Extra Hepatic Islet Transplantation (2014) [Contribution to conference › Abstract] 4th Joint EPITA and AIDPIT Winter Symposium, Innsbruck, Austria . Groot Nibbelink, M. , Skrzypek, K. , de Koning, E. J. P. , Karperien, H. B. J. , Stamatialis, D. & van Apeldoorn, A. A. Microfluidic Encapsulation of Beta cells: comparing the suitability of enzymatic, ionic and photo crosslinking hydrogels (2014) [Contribution to conference › Abstract] EPITA and AIDPIT Innsbrück, Austria . Henke, S. J. , Leijten, J. C. H. , Kemna, E. , van den Berg, A. , Dijkstra, P. J. , van Apeldoorn, A. A. & Karperien, H. B. J. Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches (2014) Advanced materials, 26(16) , 2592-2599 . Leferink, A. , Schipper, D. , Arts, E. , Vrij, E. , Rivron, N. , Karperien, M. , Mittmann, K. , van Blitterswijk, C. , Moroni, L. & Truckenmüller, R. https://doi.org/10.1002/adma.201304539 A Supramolecular Host-Guest Carrier System for Growth Factors Employing VHH Fragments (2014) Journal of the American Chemical Society, 136(36) , 12675-12681 . Cabanas Danés, J. , Rodrigues, E. D. , Landman, E. , van Weerd, J. , van Blitterswijk, C. , Verrips, T. , Huskens, J. , Karperien, M. & Jonkheijm, P. https://doi.org/10.1021/ja505695w Biological networks 101: computational modeling for molecular biologists (2014) Gene, 533(42) , 379-384 . Scholma, J. , Schivo, S. , Urquidi Camacho, R. A. , van de Pol, J. , Karperien, M. & Post, J. N. https://doi.org/10.1016/j.gene.2013.10.010 Cartilage adhesive and mechanical properties of enzymatically crosslinked polysaccharide tyramine conjugate hydrogels (2014) Polymers for advanced technologies, 25(5) , 568-574 . Wang, R. , Leber, N. , Buhl, C. , Verdonschot, N. J. J. , Dijkstra, P. J. & Karperien, H. B. J. https://doi.org/10.1002/pat.3286 Clinical outcome 3 years after autologous chondrocyte implantation does not correlate with the expression of a predefined gene marker set in chondrocytes prior to implantation but is associated with critical signaling pathways (2014) Orthopaedic Journal of Sports Medicine, 2(9) . Stenberg, J. , de Windt, T. S. , Synnergren, J. , Hynsjö, L. , van der Lee, J. , Saris, D. B. F. , Brittberg, M. , Peterson, L. & Lindahl, A. https://doi.org/10.1177/2325967114550781 Copy number variants in patients with short stature (2014) European journal of human genetics, 22(5) , 602-609 . van Duyvenvoorde, H. A. , Lui, J. C. , Kant, S. G. , Oostdijk, W. , Gijsbers, A. C. J. , Hoffer, M. J. V. , Karperien, M. , Walenkamp, M. J. E. , Noordam, C. , Voorhoeve, P. G. , Mericq, V. , Pereira, A. M. , Claahsen-van de Grinten, H. L. , van Gool, S. A. , Breuning, M. H. , Losekoot, M. , Baron, J. , Ruivenkamp, C. A. L. & Wit, J. M. https://doi.org/10.1038/ejhg.2013.203 Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes (2014) Arthritis research & therapy, 16(441) , - . Article 441 . Tsuchida, A. I. , Beekhuizen, M. , 't Hart, M. C. , Radstake, T. R. D. J. , Dhert, W. J. A. , Saris, D. B. F. , van Osch, G. J. V. M. & Creemers, L. B. https://doi.org/10.1186/s13075-014-0441-0 Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line (2014) Cartilage, 5(3) , 181-189 . Landman, E. , Periyasamy, P. C. , van Blitterswijk, C. , Post, J. N. & Karperien, H. B. J. https://doi.org/10.1177/1947603514525036 Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy (2014) Tissue engineering. Part C: Methods, 20(2) , 160-168 . Wu, L. , Gonzalez, S. , Shah, S. , Kyupelyan, L. , Petrigliano, F. A. , McAllister, D. R. , Adams, J. S. , Karperien, H. B. J. , Tuan, T.-L. , Benya, P. D. & Evseenko, D. https://doi.org/10.1089/ten.TEC.2013.0056 High Throughput Micro-Well Generation of Hepatocyte Micro-Aggregates for Tissue Engineering (2014) PLoS ONE, 9(8) , - . Article e105171 . Gevaert, E. , Dollé, L. , Billiet, T. , Dubruel, P. , van Grunsven, L. , van Apeldoorn, A. A. & Cornelissen, R. https://doi.org/10.1371/journal.pone.0105171 Hydrogels by supramolecular crosslinking of terpyridine end group functionalized 8-arm poly(ethylene glycol) (2014) Soft matter, 10(37) , 7328-7336 . Wang, R. , Geven, M. A. , Dijkstra, P. J. , Martens, P. & Karperien, H. B. J. https://doi.org/10.1039/C4SM01162G Hydrogels in a historical perspective: From simple networks to smart materials (2014) Journal of controlled release, 190 , 254-273 . Buwalda, S. J. , Boere, K. W. M. , Dijkstra, P. J. , Feijen, J. , Vermonden, T. & Hennink, W. E. https://doi.org/10.1016/j.jconrel.2014.03.052 Identification of novel SHOX target genes in the developing limb using a transgenic mouse model (2014) PLoS ONE, 9(6) , - . Article e98543 . Beiser, K. U. , Glaser, A. , Kleinschmidt, K. , Scholl, I. , Röth, R. , Li, L. , Gretz, N. , Mechtersheimer, G. , Karperien, H. B. J. , Marchini, A. , Richter, W. & Rappold, G. A. https://doi.org/10.1371/journal.pone.0098543 Injectable hydrogels for cartilage repair (2014) Osteoarthritis and cartilage, 22(Suppl.) , S151-S152 . Both, S. K. , Wang, R. , Dijkstra, P. J. & Karperien, H. B. J. https://doi.org/10.1016/j.joca.2014.02.282 Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Two-year follow-up of a prospective randomized trial (2014) The American journal of sports medicine, 42(6) , 1384-1394 . Saris, D. , Price, A. , Widuchowski, W. , Bertrand-Marchand, M. , Caron, J. , Drogset, J. O. , Emans, P. , Podskubka, A. , Tsuchida, A. I. , Kili, S. , Levine, D. & Brittberg, M. https://doi.org/10.1177/0363546514528093 Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate (2014) Proceedings of the National Academy of Sciences of the United States of America, 111(38) , 13954-13959 . Leijten, J. , Georgi, N. , Moreira Teixeira, L. , van Blitterswijk, C. , Post, J. N. & Karperien, M. https://doi.org/10.1073/pnas.1410977111 Producing artificial chondrons for improved cartilage repair (2014) Osteoarthritis and cartilage, 22(Suppl.) , S485-S486 . Kamperman, T. , Leijten, J. C. H. , Henke, S. J. & Karperien, M. https://doi.org/10.1016/j.joca.2014.02.921 Tissue Formation during Embryogenesis (2014) In Tissue Engineering (pp. 67-109) . Elsevier . Karperien, M. , Roelen, B. A. J. , Poelmann, R. E. , Gittenberger-de Groot, A. , Hierck, B. P. , DeRuiter, M. C. , Meijer, D. & Gibbs, S. https://doi.org/10.1016/B978-0-12-420145-3.00003-1 Treatment algorithm for articular cartilage repair of the knee: Towards patient profiling using evidence-based tools (2014) In Techniques in Cartilage Repair Surgery (pp. 23-31) . Springer . de Windt, T. S. & Saris, D. B. F. https://doi.org/10.1007/978-3-642-41921-8_3
2013
Introducing small cationic groups into 4-armed PLLAePEG copolymers leads to preferred micellization over thermo-reversible gelation (2013) Polymer, 54(26) , 6894-6901 . Wennink, J. W. H. , Signori, F. , Karperien, M. , Bronco, S. , Feijen, J. & Dijkstra, P. J. https://doi.org/10.1016/j.polymer.2013.11.007 Maintenance of multi-potential differentiation capacity of human mesenchymal stem cells on polymeric rapid prototyped 3D scaffolds (2013) [Contribution to conference › Poster] Till & McCulloch meetings . Leferink, A. M. , Karperien, H. B. J. , van Blitterswijk, C. & Moroni, L. Label-Free Detection of Insulin and Glucagon within Human Islets of Langerhans Using Raman Spectroscopy (2013) PLoS ONE, 8(10) , e78148-e78148 . Hilderink, J. , Otto, C. , Slump, C. H. , Lenferink, A. T. M. , Engelse, M. A. , van Blitterswijk, C. , de Koning, E. J. P. , Karperien, H. B. J. & van Apeldoorn, A. A. https://doi.org/10.1371/journal.pone.0078148 Beating diabetes: strategies to improve pancreatic islet transplantation (2013) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Hilderink, J. https://doi.org/10.3990/1.9789036507752 Amyloid Scaffolds for Cartilage Tissue Engineering: The Effect of Amyloid Structures on Cell Viability and Proliferation (2013) [Contribution to conference › Poster] Annual Dutch meeting on Molecular and Cellular Biophysics 2013 . van Dalen, M. C. E. , Karperien, H. B. J. , Subramaniam, V. , Post, J. N. & Claessens, M. M. A. E. Modulation of cholesterol metabolism for better cartilage formation by influencing FGF signaling (2013) [Contribution to conference › Poster] Annual Dutch meeting on Molecular and Cellular Biophysics 2013 . Georgi, N. , Cillero Pastor, B. , Wu, L. , Eijkel, G. , Kiss, A. , Gratton, R. , WIlson, B. , Heeren, R. M. A. , Karperien, H. B. J. & Post, J. N. GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis associated factors (2013) Arthritis research & therapy, 15(5) , 1-11 . Article R126 . Leijten, J. C. H. , Bos, S. D. , Landman, E. B. M. , Georgi, N. , Jahr, H. , Meulenbelt, I. , Post, J. N. , van Blitterswijk, C. A. & Karperien, M. https://doi.org/10.1186/ar4306 Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures (2013) Tissue engineering. Part B: Reviews, 19(1) , 31-40 . Leijten, J. C. H. , Georgi, N. , Wu, L. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.1089/ten.TEB.2012.0273 Branched biodegradable polymers, a macromonomer, processes for the preparation of same, and their use (2013) [Patent › Patent] (Submitted) . Feijen, J. , Zhong, Z. & Dijkstra, P. J. http://www.uspto.gov/web/patents/patog/week30/OG/html/1392-4/US08492505-20130723.html Pleisters plakken (2013) [Book/Report › Inaugural speech] . University of Twente . Karperien, H. B. J. Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans (2013) PLoS ONE, 8(5) . Article e64772 . Buitinga, M. , Truckenmüller, R. , Engelse, M. A. , Moroni, L. , ten Hoopen, H. W. M. , van Blitterswijk, C. A. , de Koning, E. J. P. , van Apeldoorn, A. A. & Karperien, M. https://doi.org/10.1371/journal.pone.0064772 The effect of donor variation and senescence on endothelial differentiation of human mesenchymal stromal cells (2013) Tissue engineering. Part A, 19(21-22) , 2318-2329 . Portalska, K. K. , Groen, N. , Krenning, G. , Georgi, N. , Mentink-Leusink, A. , Harmsen, M. C. , van Blitterswijk, C. & de Boer, J. https://doi.org/10.1089/ten.TEA.2012.0646 Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: Perspectives from stem cell biology and molecular medicine (2013) Journal of cellular physiology, 228(5) , 938-944 . Wu, L. , Cai, X. , Zhang, S. , Karperien, M. & Lin, Y. https://doi.org/10.1002/jcp.24255 Mathematical modeling of signaling pathways in osteoarthritis (2013) In 2013 Osteoarthritis Research Society International (OARSI) World Congress (pp. -) (S123; Vol. 21) . Elsevier . Scholma, J. , Kerkhofs, J. , Schivo, S. , Langerak, R. , van der Vet, P. E. , Karperien, H. B. J. , van de Pol, J. C. , Geris, L. & Post, J. N. https://doi.org/10.1016/j.joca.2013.02.259 TCF4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating NF-κB signaling (2013) Journal of biological chemistry, 288 , 17552-17558 . Ma, B. , Zhong, L. , van Blitterswijk, C. , Post, J. N. & Karperien, H. B. J. https://doi.org/10.1074/jbc.M113.453985 Fibroblast growth factor-1 is a mesenchymal stromal cell secreted factor stimulating proliferation of Osteoarthritic chondrocytes (2013) [Contribution to conference › Abstract] 2013 OARSI World Congress on Osteoarthrtis . Ling, W. , Leijten, J. C. H. , Post, J. N. & Karperien, H. B. J. Biodegradable hydrogels by physical and enzymatic crosslinking of biomacromolecules (2013) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Wennink, J. W. H. https://doi.org/10.39990/1.9789036535038 Insulin-like-growth-factor-I enhances proliferation and differentiation of human mesenchymal stromal cells in vitro (2013) Tissue engineering. Part A, 19(15-16) , 1817-1828 . Doorn, J. , Roberts, S. J. , Hilderink, J. , Groen, N. , van Apeldoorn, A. A. , van Blitterswijk, C. , Schrooten, J. & de Boer, J. https://doi.org/10.1089/ten.TEA.2012.0522 Multiple choice: leveraging instructive culture models to improve cartilage tissue engineering (2013) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Georgi, N. https://doi.org/10.3990/1.9789036535205 Molecular modulation of articular cartilage degradation (2013) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Landman, E. B. M. A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering (2013) Tissue engineering. Part C: Methods, 19(10) , 774-783 . Spitters, T. , Leijten, J. C. H. , Deus, F. D. , Costa, I. B. F. , van Apeldoorn, A. A. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.1089/ten.TEC.2012.0435 Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture (2013) Osteoarthritis and cartilage, 21(4) , 599-603 . Ma, B. , Leijten, J. C. H. , Wu, L. , Kip, M. M. A. , van Blitterswijk, C. , Post, J. N. & Karperien, H. B. J. https://doi.org/10.1016/j.joca.2013.01.014 Synthesis and thermal properties of hetero-bifunctional PLA oligomers and their stereocomplexes (2013) Reactive & functional polymers, 73(1) , 30-38 . ten Breteler, M. R. , Feijen, J. , Dijkstra, P. J. & Signori, F. https://doi.org/10.1016/j.reactfunctpolym.2012.10.003 A fluorogenic monolayer to detect the co-immobilization of peptides that combine cartilage targeting and regeneration (2013) Journal of materials chemistry. B: materials for biology and medicine, 1(14) , 1903-1908 . Cabanas Danés, J. , Nicosia, C. , Landman, E. , Karperien, M. , Huskens, J. & Jonkheijm, P. https://doi.org/10.1039/C3TB20109K Effect of radiation on the Notch signaling pathway in osteoblasts (2013) International journal of molecular medicine, 31(3) , 698-706 . Yang, B. , Tang, Q. , Post, J. , Zhou, H. , Huang, X.-B. , Zhang, X.-D. , Wang, Q. , Sun, Y.-M. & Fan, F.-Y. https://doi.org/10.3892/ijmm.2013.1255 Fabrication, Characterization and Cellular Compatibility of Poly(Hydroxy Alkanoate) Composite Nanofibrous Scaffolds for Nerve Tissue Engineering (2013) PLoS ONE, 8(2) , 1-13 . Article e57157 . Masaeli, E. , Morshed, M. , Hossein Nasr-Esfahani, M. , Sadri, S. , Hilderink, J. , van Apeldoorn, A. A. , van Blitterswijk, C. & Moroni, L. https://doi.org/10.1371/journal.pone.0057157 Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture (2013) Stem cells and development, 22(17) , 2356-2367 . Wu, L. , Leijten, J. C. H. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.1089/scd.2013.0118 In vivo screening of extracellular matrix components produced under multiple experimental conditions implanted in one animal (2013) Integrative biology, 2013(6) , 889-898 . Higuera, G. A. , Hendriks, J. A. A. , van Dalum, J. , Wu, L. , Schotel, R. , Moreira-Teixeira, L. , van den Doel, M. , Leijten, J. C. H. , Riesle, J. , Karperien, M. , van Blitterswijk, C. & Moroni, L. https://doi.org/10.1039/C3IB40023A Influence of the solvent type on the morphology and mechanical properties of electrospun PLLA yarns (2013) Biofabrication, 5(3) , - . Article 035014 . Maleki, H. , Gharehaghaji, A. A. , Moroni, L. & Dijkstra, P. J. https://doi.org/10.1088/1758-5082/5/3/035014 Injecteerbare pleister op komst (2013) Rond reuma, 2013(maart) , 4-6 . Karperien, H. B. J. Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds (2013) Journal of the Royal Society. Interface, 10(86) , - . Article 20130464 . Kunstar, A. , Leferink, A. M. , Okagbare, P. I. , Morris, M. D. , Roessler, B. J. , Otto, C. , Karperien, H. B. J. , van Blitterswijk, C. , Moroni, L. & van Apeldoorn, A. A. https://doi.org/10.1098/rsif.2013.0464 MicroRNAs are prognostic markers for the chondrogenic potential of MSCs (2013) Osteoarthritis and cartilage, 21(Suppl.) , S31-S32 . Georgi, N. , Taipaleenmaki, H. , van Wijnen, A. , Groen, N. , Janaeczek-Portalska, K. , van Blitterswijk, C. A. , de Boer, J. , Post, J. N. & Karperien, M. https://doi.org/10.1016/j.joca.2013.02.085 Nanoparticle system for the local delivery of disease modifying osteoarthritic drugs (2013) Osteoarthritis and cartilage, 21(Supplement) , S303-S304 . Periyasamy, P. C. , Wennink, J. W. H. , Wang, R. , Karperien, H. B. J. , Dijkstra, P. J. & Post, J. N. https://doi.org/10.1016/j.joca.2013.02.633 Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering (2013) PLoS ONE, 8(2) , - . Article e55451 . Silva, J. M. , Georgi, N. , Costa, R. , Sher, P. , Reis, R. L. , van Blitterswijk, C. , Karperien, H. B. J. & Mano, J. F. https://doi.org/10.1371/journal.pone.0055451 PDB73 – The Expected Value Of Bio-Artificial Pancreas Development In View Of Endocrinologists' And Patients' Preferences (2013) Value in health, 16(3) , A169- . Wissing, T. B. , van Apeldoorn, A. A. & IJzerman, M. J. https://doi.org/10.1016/j.jval.2013.03.845 Process for the preparation of a scaffold supporting a lipid bilayer (2013) [Patent › Patent] (In preparation) . van Weerd, J. , Karperien, H. B. J. & Jonkheijm, P. Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes (2013) In Unknown (pp. S122-S123) . Zhong, L. , Ma, B. , Post, J. N. & Karperien, H. B. J. https://doi.org/10.1016/j.joca.2013.02.258 Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation (2013) Arthritis research & therapy, 15(4) . Article R93 . Landman, E. B. M. , Miclea, R. L. , van Blitterswijk, C. & Karperien, M. https://doi.org/10.1186/ar4273 WNT Signaling and Cartilage: Of Mice and Men (2013) Calcified tissue international, 92(5) , 399-411 . Ma, B. , Landman, E. , Miclea, R. L. , Wit, J. M. , Robanus-Maandag, E. C. , Post, J. N. & Karperien, H. B. J. https://doi.org/10.1007/s00223-012-9675-5
2012
Dextran-hyaluronic acid based hydrogels (2012) [Patent › Patent] . Jin, R. , Moreira Teixeira, L. , Feijen, J. , Dijkstra, P. J. & Karperien, M. Sotos Syndrome Is Associated with Deregulation of the MAPK/ERK-Signaling Pathway (2012) PLoS ONE, 7(11) . Article e49229 . Visser, R. , Landman, E. B. M. , Goeman, J. , Wit, J. M. & Karperien, M. https://doi.org/10.1371/journal.pone.0049229 Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis (2012) [Non-textual form › Web publication/site] . F1000 Rheumatology & Clinical Immunology . Leijten, J. C. H. , Emons, J. , Sticht, C. , van Gool, S. , Decker, E. , Uitterlinden, A. , Rappold, G. , Hofman, A. , Rivadeneira, F. , Scherjon, S. , Wit, J. M. , van Meurs, J. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.3410/f.717961030.793463944 Hydrogels based on polymers of dextran tyramine and tyramine conjugates of natural polymers (2012) [Patent › Patent] . Feijen, J. , Karperien, M. , Jin, R. , Moreira Teixeira, L. & Dijkstra, P. J. Modelling biological pathway dynamics with Timed Automata (2012) In 2012 IEEE 12th International Conference on Bioinformatics and Bioengineering (BIBE 2012) (pp. 447-453) . IEEE . Schivo, S. , Scholma, J. , Wanders, B. , Urquidi Camacho, R. A. , van der Vet, P. E. , Karperien, H. B. J. , Langerak, R. , van de Pol, J. C. & Post, J. N. https://doi.org/10.1109/BIBE.2012.6399719 Stress-strain measurements of single micro and nanoscale fibers with modified AFM cantilevers (2012) [Contribution to conference › Poster] 4th Multifrequency Conference . Bennink, M. L. , van der Werf, K. , Sijbrandi, N. J. , Dijkstra, P. J. , Feijen, J. & Subramaniam, V. Poly(bisoxalamides) (2012) [Patent › Patent] . Broos, R. , Sijbrandi, N. , Dijkstra, P. & Feijen, J. Mesenchymal stem cells as trophic mediators in cartilage regeneration (2012) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Wu, L. https://doi.org/10.3990/1.9789036533973 Wnt signaling in cartilage development and degeneration (2012) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Ma, B. https://doi.org/10.3990/1.9789036534222 Improved Neocartilage Fomation in Dex-TA Hydrogels by Seeding Cell Micro-aggregates Produced in A (2012) [Contribution to conference › Poster] 9th World Biomaterials Congress, WBC 2012 . Leijten, J. C. H. , Moreira Teixeira, L. , Sobral, J. , Jin, R. , van Apeldoorn, A. A. , Feijen, J. , van Blitterswijk, C. , Dijkstra, P. J. & Karperien, H. B. J. Screening in vitro and in vivo to Reduce Animal Experiments (2012) [Contribution to conference › Poster] 9th World Biomaterials Congress, WBC 2012 . Higuera Sierra, G. , Wu, L. , Moreira Teixeira, L. , Leijten, J. C. H. , Karperien, H. B. J. , van Blitterswijk, C. , Moroni, L. & van Dalum, J. Vroege opsporing Artrose wordt eenvoudiger (2012) Reuma Magazine.nl , - . Leijten, J. C. H. http://www.reumafonds.nl/actueel/nieuwsoverzicht/2012/vroege-opsporing-artrose-dichterbij A quest for copy number variations causing extreme tall stature (2012) [Contribution to conference › Poster] European Society for Pediatric Endocrinology Annual Meeting 2012 . Duyvenvoorde, H. A. , Ruivenkamp, C. A. , Mul, D. , Oostdijk, W. , Karperien, M. , Losekoot, M. , Pereira, A. M. , Kant, S. G. & Wit, J. M. Bioactive hydrogels to induce angiogenesis and improve islets of Langerhans viability (2012) [Contribution to conference › Poster] 20th NBTE Annual Meeting 2011 . Marchioli, G. , Engelse, M. A. , Dijkstra, P. J. , de Koning, E. J. P. , Karperien, H. B. J. , van Blitterswijk, C. , Moroni, L. & van Apeldoorn, A. A. Copy number variations in patients with idiopathic short stature (2012) [Contribution to conference › Poster] European Society for Pediatric Endocrinology Annual Meeting 2012 . van Duyvenvoorde, H. A. , Lui, J. , Kant, S. G. , Oostdijk, W. , Gijsbers, A. C. J. , Karperien, M. , Walenkamp, M. J. E. , Noordam, C. , Voorhoeve, P. G. , Mericq, V. , van Gool, S. A. , Breuning, M. H. , Losekoot, M. , Baron, J. , Ruivenkamp, C. A. & Wit, J. M. Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering (2012) Biomaterials, 33(5) , 1281-1290 . Moreira Teixeira, L. , Feijen, J. , van Blitterswijk, C. , Dijkstra, P. J. & Karperien, H. B. J. https://doi.org/10.1016/j.biomaterials.2011.10.067 Fetal Mesenchymal Stromal Cells Differentiating towards Chondrocytes Acquire a Gene Expression Profile Resembling Human Growth Plate Cartilage (2012) PLoS ONE, 7(11) , 1-11 . Article e44561 . van Gool, S. A. , Emons, J. A. M. , Leijten, J. C. H. , Decker, E. , Sticht, C. , van Houwelingen, J. C. , Goeman, J. J. , Kleijburg, C. , Scherjon, S. , Gretz, N. , Wit, J. M. , Rappold, G. , Post, J. N. & Karperien, H. B. J. https://doi.org/10.1371/journal.pone.0044561 Fluorescently Labeled Branched Polymers and Thermal Responsive Nanoparticles for Live Cell Imaging (2012) Macromolecular bioscience, 12(4) , 465-474 . Zhou, D. , Ma, Y. , Poot, A. A. , Dijkstra, P. J. & Feijen, J. https://doi.org/10.1002/mabi.201100254 Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis (2012) Arthritis & rheumatism, 64(10) , 3302-3312 . Leijten, J. C. H. , Emons, J. , Sticht, C. , van Gool, S. , Decker, E. , Uitterlinden, A. , Rappold, G. , Hofman, A. , Rivadeneira, F. , Scherjon, S. , Wit, J. M. , van Meurs, J. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.1002/art.34535 High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo (2012) European cells & materials, 23 , 387-399 . Moreira Teixeira, L. , Leijten, J. C. H. , Sobral, J. , Jin, R. , van Apeldoorn, A. A. , Feijen, J. , van Blitterswijk, C. , Dijkstra, P. J. & Karperien, H. B. J. http://www.ecmjournal.org/journal/papers/vol023/vol023a30.php Hypoxia Inhibits Hypertrophic Differentiation and Endochondral Ossification in Explanted Tibiae (2012) PLoS ONE, 7(11) , 1-7 . Article e49896 . Leijten, J. C. H. , Moreira Teixeira, L. , Landman, E. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.1371/journal.pone.0049896 In situ forming poly(ethylene glycol)- Poly(L -lactide) hydrogels via michael addition: Mechanical properties, degradation, and protein release (2012) Macromolecular chemistry and physics, 213(7) , 766-775 . Buwalda, S. J. , Dijkstra, P. J. & Feijen, J. https://doi.org/10.1002/macp.201100640 Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model (2012) Arthritis research & therapy, 14(R262) , - . Article R262 . Tsuchida, A. I. , Beekhuizen, M. , Rutgers, M. , van Osch, G. J. V. M. , Bekkers, J. E. J. , Bot, A. G. J. , Geurts, B. , Dhert, W. J. A. , Saris, D. B. F. & Creemers, L. B. https://doi.org/10.1186/ar4107 Mechanical testing of electrospun PCL fibers (2012) Acta biomaterialia, 8(1) , 218-224 . Croisier, F. , Duwez, A.-S. , Jerome, C. , Leanard, A. F. , van der Werf, K. , Dijkstra, P. J. & Bennink, M. L. https://doi.org/10.1016/j.actbio.2011.08.015 Micromechanical analysis of native and cross-linked collagen type 1 fibrils supports the existence of microfibrils (2012) Journal of the mechanical behavior of biomedical materials, 6 , 148-158 . Yang, L. , van der Werf, K. , Dijkstra, P. J. , Feijen, J. & Bennink, M. L. https://doi.org/10.1016/j.jmbbm.2011.11.008 Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs (2012) Journal of nanomaterials, 2012(673968) , - . Article 673968 . Periyasamy, P. C. , Leijten, J. C. H. , Dijkstra, P. J. , Karperien, H. B. J. & Post, J. N. https://doi.org/10.1155/2012/673968 Osteoarthritis: Control of human cartilage hypertrophic differentiation. Research highlight van: Gremlin1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis (2012) Nature reviews rheumatology, 8(7) , 368- . Buckland, J. , Leijten, J. C. H. , van Blitterswijk, C. & Karperien, H. B. J. https://doi.org/10.1038/nrrheum.2012.82 Poly(ethylene glycol)-poly(L -lactide) star block copolymer hydrogels crosslinked by metal-ligand coordination (2012) Journal of polymer science. Part A: Polymer chemistry, 50(9) , 1783-1791 . Buwalda, S. J. , Dijkstra, P. J. & Feijen, J. https://doi.org/10.1002/pola.25945 Recent insights from scanning electron microscopic assessment of durable polymer-coated drug-eluting stents (2012) Interventional cardiology, 4(6) , 661-674 . Basalus, M. W. Z. , Tandjung, K. , Sen, H. , van Apeldoorn, A. A. , Grijpma, D. W. & von Birgelen, C. https://doi.org/10.2217/ica.12.67 Recognizing different tissues in human fetal femur cartilage by label-free Raman microspectroscopy (2012) Journal of biomedical optics, 17(11) , - . Article 116012 . Kunstar, A. , Leijten, J. C. H. , van Leuveren, S. , Hilderink, J. , Otto, C. , van Blitterswijk, C. , Karperien, H. B. J. & van Apeldoorn, A. A. https://doi.org/10.1117/1.JBO.17.11.116012 Scanning electron microscopic assessment of coating irregularities and their precursors in unexpanded durable polymer-based drug-eluting stents (2012) Catheterization and cardiovascular interventions, 79(4) , 644-653 . Basalus, M. W. Z. , Tandjung, K. , van Westen, T. , Sen, H. , van der Jagt, P. K. N. , Grijpma, D. W. , van Apeldoorn, A. A. & von Birgelen, C. https://doi.org/10.1002/ccd.23273 Self-attaching and cell-attracting in-situ forming dextran-tyramine conjugates hydrogels for arthroscopic cartilage repair (2012) Biomaterials, 33(11) , 3164-3174 . Moreira Teixeira, L. , Bijl, S. , Pully, V. V. , Otto, C. , Jin, R. , Feijen, J. , van Blitterswijk, C. , Dijkstra, P. J. & Karperien, H. B. J. https://doi.org/10.1016/j.biomaterials.2012.01.001 Stereocomplexed 8-armed poly(ethylene glycol)-poly(lactide) star block copolymer hydrogels: Gelation mechanism, mechanical properties and degradation behavior (2012) Polymer, 53(14) , 2809-2817 . Buwalda, S. J. , Calucci, L. , Forte, C. , Dijkstra, P. J. & Feijen, J. https://doi.org/10.1016/j.polymer.2012.05.006 Synthesis, morphology and properties of segmented poly(ether ester amide)s comprising uniform glycine or β-alanine extended bisoxalamide hard segments (2012) Polymer, 53(19) , 4033-4044 . Sijbrandi, N. J. , Kimenai, A. J. , Mes, E. P. C. , Broos, R. , Bar, G. , Rosenthal, M. , Odarchenko, Y. , Ivanov, D. A. , Feijen, J. & Dijkstra, P. J. https://doi.org/10.1016/j.polymer.2012.07.015 Synthesis, morphology, and properties of segmented poly(ether amide)s with uniform oxalamide-based hard segments (2012) Macromolecules, 45(9) , 3948-3961 . Sijbrandi, N. J. , Kimenai, A. J. , Mes, E. P. C. , Broos, R. , Bar, G. , Rosenthal, M. , Odarchenko, Y. , Ivanov, D. A. , Dijkstra, P. J. & Feijen, J. https://doi.org/10.1021/ma2022309 The effect of platelet lysate supplementation of a dextran-based hydrogel on cartilage formation (2012) Biomaterials, 33(14) , 3651-3661 . Moreira Teixeira, L. S. , Leijten, J. C. H. , Wennink, J. W. H. , Chatterjea, A. G. , Feijen, J. , van Blitterswijk, C. A. , Dijkstra, P. J. & Karperien, M. https://doi.org/10.1016/j.biomaterials.2012.01.051 Wettability influences cell behavior on superhydrophobic surfaces with different topographies (2012) Biointerphases, 7(46) , 1-11 . Lourenco, B. N. , Marchioli, G. , Song, W. , Reis, R. L. , van Blitterswijk, C. , Karperien, H. B. J. , van Apeldoorn, A. A. & Mano, J. F. https://doi.org/10.1007/s13758-012-0046-6
2011
HYDROGELS BASED ON POLYMERS OF DEXTRAN TYRAMINE AND TYRAMINE CONJUGATES OF NATURAL POLYMERS (2011) [Patent › Patent] . Karperien, H. B. J. , Jin, R. , Moreira Teixeira, L. , Feijen,, J. & Dijkstra, P. J. Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells (2011) Journal of tissue engineering and regenerative medicine, 5(3) , 180-190 . Both, S. K. , van Apeldoorn, A. A. , Jukes, J. M. , Englund, M. C. O. , Hyllner, J. , van Blitterswijk, C. & de Boer, J. https://doi.org/10.1002/term.303 Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo (2011) Clinical sarcoma research, 1 . Article 5 . Meijer, D. , Gelderblom, H. , Karperien, M. , Cleton-Jansen, A.-M. , Hogendoorn, P. C. W. & Bovée, J. V. M. G. https://doi.org/10.1186/2045-3329-1-5 Genome-wide association identifies three new susceptibility loci for Paget's disease of bone (2011) Nature genetics, 43(7) , 685-689 . Albagha, O. M. E. , Wani, S. E. , Visconti, M. R. , Alonso, N. , Goodman, K. , Brandi, M. L. , Cundy, T. , Chung, P. Y. J. , Dargie, R. , Devogelaer, J.-P. , Falchetti, A. , Fraser, W. D. , Gennari, L. , Gianfrancesco, F. , Hooper, M. J. , van Hul, W. , Isaia, G. , Nicholson, G. C. , Nuti, R. , … Karperien, H. B. J. https://doi.org/10.1038/ng.845
2010
Dextran-tyramine Hydrogels for Cartilage Repair: Enhanced Chondrogenicity by Engraftment with Hyaluronic Acid and Heparin (2010) [Contribution to conference › Abstract] TERMIS-EU Chapter Meeting 2010 . Moreira Teixeira, L. , Jin, R. , Dijkstra, P. T. S. , van Blitterswijk, C. , Feijen, J. & Karperien, H. B. J. https://www.termis.org/docs/eu10_abstracts/TERMIS2010_0371.pdf Materiomics: Dealing with complexity in tissue engineering (2010) European cells & materials, 20(SUPPL. 1) . van Blitterswijk, C. A. , Stamatialis, D. , Unadkat, H. , Papenburg, B. , Rouwkema, J. , Truckenmuller, R. , van Apeldoorn, A. , Wessling, M. & de Boer, J.
2009
Scaffold for diabetes treatment (2009) [Patent › Patent] (Submitted) . van Apeldoorn, A. A. , van Blitterswijk, C. , Engelse, M. A. , de Koning, E. J. P. & Karperien, H. B. J.
2007
Cell-based and molecular imaging tools for validating new therapies in the treatment of bone metabolic disorders and metastases (2007) Current opinion in molecular therapeutics, 8(6) , 477-479 . Kaijzel, E. L. , Karperien, M. , van der Horst, G. , van der Pluijm, G. , Löwik, C. W. G. M. & Chan, A.
2003
Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET) (2003) Biochemical Society transactions, 31(5) , 1020-1027 . Lidke, D. S. , Nagy, P. , Barisas, B. G. , Heintzmann, R. , Post, J. N. , Lidke, K. A. , Clayton, A. H. A. , Arndt-jovin, D. J. & Jovin, T. M. https://doi.org/10.1042/bst0311020
2001
Nuclear localization signals in the Xenopus FGF embryonic early response 1 protein (2001) FEBS letters, 502(1-2) , 41-45 . Post, J. N. , Gillespie, L. L. & Paterno, G. D. https://doi.org/10.1016/S0014-5793(01)02653-9