Publications

2020-2025

20. Lieke Pieters, Talitha C. Visser,* Albert S. Y. Wong*, "Preparing the Next-generation Chemistry Student for Systems Thinking: Bridging Secondary and Higher Education" under review

19. A. Hazal Koyuncu, Albert S. Y. Wong*, "Harnessing Material Interfaces for the Design of Intelligent Chemical Feedback Loops" under review 

18. Pei, L.; Onnink,A.J.; Susarrey-Arce, A.; van Lente, J.J.; Wong, A.S.Y.; ten Elshof, J.E.; Wormeester, H.; Krab-Hüsken,L.E. "Integrating Systems Thinking and Essential Skills into Chemistry Education: The CLEAR Initiative for Sustainability" Proceedings of the 12^th EESD Conference (EESD2025) 2025, London, United Kingdom. 

17. Dávid Komáromy, Aisha N. Bismillah, Vedang A. Puranik, Heyifei Fu, Albert S.Y. Wong, Ivan Aprahamian*, "Coupling Synthetic Negative Feedback Loops" Chem. 2025, 12, 102692. DOI: 10.1016/j.chempr.2025.102692

16. Éverton F. da Cunha,^# Yanna J. Kraakman,# Dmitrii V. Kriukov, Thomas van Poppel, Clara Stegehuis*, Albert S. Y. Wong*, "Identify structures underlying out-of-equilibrium reaction networks with random graph analysis" Chem. Sci. 2025, 16, 3099 - 3106. DOI: https://doi.org/10.1039/D4SC05234J

15. Dmitrii V. Kriukov, Jurriaan Huskens, Albert S. Y. Wong*, "Exploring the Programmability of Autocatalytic Chemical Reaction Networks" Nat. Commun. 2024, 15, 8289. DOI: https://doi.org/10.1038/s41467-024-52649-z  

This work appearedand in several media outlets, four national (C2W-Mens&Milieu, DeIngenieur, NewScientist, and Nationaleonderwijsgids) and five international news outlets (Phys.org, EngineersOnline, inovacaotecnologica, Nanowerk, and M2PressWIRE).

14. Koyuncu, A. H.; Allegri, G.; Moazzenzade, T.; Huskens, J.; Lindhoud, S.; Wong, A. S. Y.* "Molecular Information Processing in a Chemical Reaction Network using Surface-Mediated Polyelectrolyte Complexation" ChemSystemsChem 2024, e202400050, 1-7. DOI: http://dx.doi.org/10.1002/syst.202400050.

13. Krab-Hüsken, L. E.; Pei, L.; de Vries, P. G.; Lindhoud, S.; Paulusse, J. M. J.; Jonkheijm, P.; Wong, A. S. Y.* “Conceptual Modeling enables Systems Thinking in Sustainable Chemistry and Chemical Engineering” J. Chem. Educ. 2023, 100, 12, 4577–4584. https://doi.org/10.1021/acs.jchemed.3c00337.

This work appearedand in C2W Mens&Molecule as "Uitzoomen en vooruitkijken: conceptueel modelleren in de klas" , UT News as "Facilitating learning chemistry with conceptual modeling (EN)", and MySicence as "Facilitating learning chemistry with conceptual modelling".

12. Koyuncu, A. H.; Movilli, J.; Sahin, S.; Kriukov, D. V.; Huskens, J.;* Wong, A. S. Y.* “Polylysine-coated surfaces drive competition in chemical reaction networks to enable molecular information processing” ChemSystemsChem 2023, 6, e20230003, 1-7. https://doi.org/10.1002/syst.202300030. 

This work appeared in C2W Mens&Molecule as "Evenwichtsverstorende coating (NL)" and was selected as Cover Art in ChemSystemsChem. 

11. ter Harmsel, M.; Maguire, O. R.; Runikhina, S. A.; Wong, A. S. Y.; Huck, W. T. S.*; Harutyunyan, S. R.* “A catalytically active small organic molecule oscillator” Nature 2023, 621, 87–93. https://doi.org/10.1038/s41586-023-06310-2 

10. Kriukov, D. V.; Koyuncu, A. H.; Wong, A. S. Y.* "History dependence in a chemical reaction network enables dynamic switching" Small 2022, 18, 2107523, 1-7. https://doi.org/10.1002/smll.202107523

This work appeared in UT News as "Calculating with chemical reactions with a memory" (in Dutch "Rekenen met slimme chemie die kan onthouden"). 

2015-2020

9. Maguire, O. R.; Wong, A. S. Y.; Westerdiep, J. H.; Huck, W. T. S.* “Early Warning Signals in Chemical Reaction Networks” Chem. Commun. 2020, 56, 3725-3728 DOI: 10.1039/D0CC01010C

8. Maguire, O. R.; Wong, A. S. Y.; Baltussen, M. G.; van Duppen, P.; Pogodaev, A. A.; Huck, W. T. S.* “Dynamic Environments as a Tool to preserve Desired Output in a Chemical Reaction Network” Chem. Eur. J. 2020, 26, 1676-1682. DOI: 10.1002/chem.201904725

7. Cafferty, B. J.; Wong, A. S. Y.; Semenov, S. N.; Belding, L.; Gmuer, S.; Huck, W. T. S.; and Whitesides. G. M.* “Robustness, Entrainment, and Hybridization in Dissipative Molecular Networks, and the Origin of Life” J. Am. Chem. Soc. 2019, 141 (20), 8289-8295. DOI: 10.1021/jacs.9b02554

6. Pogodaev, A. A.; Wong, A. S. Y.; Huck, W. T. S.* “Photochemical Control over Oscillations in Chemical Reaction Networks” J. Am. Chem. Soc. 2017, 139, 15296-15299. DOI: 10.1021/jacs.7b08109

5. Wong, A. S. Y.*; Huck, W. T. S.* “Grip on Complexity in Chemical Reaction Networks” Beilstein J. Org. Chem.2017, 13, 1486–1497. DOI: 10.3762/bjoc.13.147

4. Postma, S. G. J.; te Brinke, D.; Vialshin, I. N.; Wong, A. S. Y.; Huck, W. T. S.* “A Trypsin-based Bistable Switch”, Tetrahedron Lett. 2017, 73 (33), 4896–4900. DOI: 10.1016/j.tet.2017.04.053

3. Wong, A. S. Y.; Pogodaev, A. A.; Vialshin, I. N.; Helwig, B.; Huck, W. T. S.* “Molecular Engineering of Robustness and Resilience in Enzymatic Reaction Networks” J. Am. Chem. Soc. 2017, 139 (24), 8146 – 8151. DOI: 10.1021/jacs.7b00632 

2. Wong, A. S. Y.; Postma, S. G. J.; Vialshin, I. N.; Semenov, S. N.; Huck, W. T. S.* “The Influence of Molecular Structure on the Properties of Out-of-equilibrium Oscillating Enzymatic Reaction Networks” J. Am. Chem. Soc. 2015, 137, 12415−12420. DOI: 10.1021/jacs.5b08129

1. Semenov, S. N.^#; Wong, A. S. Y.^#; Van der Made, R. M.; Postma, S. G. J.; Groen, J.; Van Roekel, H. W. H.; De Greef, T. F. A.; Huck, W. T. S.* “Rational Design of Functional and Tunable Oscillating Enzymatic Networks” Nat. Chem. 2015, 7, 160-165. ^#Authors with equal contributions. DOI: 10.1038/nchem.2142

2. Fink, M. J.; Wong, A. S. Y.; Whitesides, G. M. "Sparse and non-sparse coding in molecular data storage" 2021, Patent No. WO 2021/062220.

1. Wong, A. S. Y.; Fink, M. J.; Mohamed, K. A.; Whitesides, G. M. "Array-based molecular computation on reactive surfaces". 2021, Patent No. WO/2021/041667.