Phone: +31 (0)53 489 1116
My name is Sara Monteiro and I was born in Coimbra, known as the city of students, in the centre of Portugal. I received my bachelor’s degree in Biomedical Engineering, at the Faculty of Science and Technology of the University of Coimbra, Portugal. In 2018, I became a master student at the University of Twente, after extending my ERASMUS programme. Last semester, I performed an internship at the University of Genova (Italy) where I became familiar with the Micro Electrode Array (MEA) Technology and had the chance to develop a project on rat cortical cultures coupled MEAs and the effects of electrical and chemical stimulation. I have always been interested in neuroscience and my goal is to acquire knowledge in order to analyse and solve problems in the area of healthcare and medicine. At the moment, I am working on my MSc thesis at the Clinical Neurophysiology Group.
When a stroke occurs, the region close to the ictal site - penumbra - is not irreversibly damaged and is still active for a few days. However, there is limited knowledge on the factors that initiate the transition to irreversible damage. In my master thesis assignment, I will use neuronal cultures differentiated from human induced Pluripotent Stem Cells (iPSCs) to model ischemic penumbra. By modelling this effect on human neurons coupled to Micro Electrode Arrays (MEA) and electrically/optogenetically stimulating them during hypoxia, I aim to improve the survival of these cells and provide a better insight on their behaviour.