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Microfluidic Organ-Chip Platforms

In the Applied Stem Cell Technologies group, we use a number of well-characterized, microfluidic 'platforms' for our organ-on-chip models. The platforms are briefly described below, together with some of the key publications and examples of how they have been applied. The list is not exhaustive: new platforms are continuously being developed in our group.

Basic Vessel-Chip

The basic vessel-chip is a simple microfluidic channel of approximately 0.5 mm wide, 0.1 mm high and 2 cm long. The surfaces of the channels are fully covered with endothelial cells, and fluids can be perfused in the chips at controlled flow rates.

The most basic description of the vessel-chip can be found in Jain, Van der Meer, et al. "Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium." Biomedical microdevices 18(4):73 (2016).

The basic vessel-chip technology has been applied in many projects, for example:

3D vessel-chip

The 3D vessel-chip is a microfluidic channel with of 1 mm width, 1 mm height and 2 cm length, filled with an extracellular matrix hydrogel, containing a hollow lumen lined by endothelium.

The most basic description of the 3D vessel-chip can be found in Herland, Van der Meer, et al. "Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3D human blood-brain barrier on a chip." PLoS One 11(3):e0150360 (2016).

The 3D vessel-chip technology is currently being applied in multiple projects (e.g. in building a retina-on-a-chip and a neurovascular unit-on-chip).