Assignments 2011-2012

Fusion of myocardial perfusion SPECT with High-resolution cardiac CT

Voorstel MDO-opdracht

Opleiding Technische Geneeskunde

Universiteit Twente

A. Algemeen

1. Titel MDO-opdracht:

Fusion of myocardial perfusion SPECT with high-resolution cardiac CT

2. Gegevens instelling/indiener:

Naam indiener: B.J. de Wit – van der Veen, MSc.

Instelling/afdeling: sectie Nucleaire Geneeskunde, LUMC

Contactgegevens: 071 – 526 3475 (secretariaat) of

Medisch begeleider: dr. I. Al Younis

Technologisch begeleider (UT): C.H. Slump (EWI/S&S)

Vanuit het Laboratorium voor Klinische en Experimentele Beeldverwerking (LUMC) wordt ook technologische begeleiding gegeven.

B. Faciliteiten

1. Welke faciliteiten zijn nodig voor een adequate uitvoering van de vraagstelling?

-Workstations with Matlad or MedVisLab (exact image processing tool to be determined during the project)

-Access to MPS and high-resolution CT data of a number of patients

2. Wat zijn daarbij mogelijke risico’s voor de voortgang van de opdracht?

No delays are expected, as both medical images and software systems are already available.

C. Overige opmerkingen

As this project is a collaboration between the ‘Laboratorium voor Klinische en Experimentele Beeldverwerking’ (LKEB) and the section Nuclear Medicine, both institutions will provide their assistance when needed.

The maximum number of students working on this project is four; however, ideally we want a smaller group of three students working on this project.

D. Inhoudelijke informatie MDO-opdracht

1. Omschrijving van de technisch geneeskundige vraagstelling (maximaal 400 woorden)

N.B.: zo mogelijk directe afstemming tussen medische en technische groep, anders hiervoor contact opnemen met de opleiding TG.

Fusion of myocardial perfusion SPECT with High-resolution cardiac CT

Cardiovascular diseases and ischemic heart diseases in particular, are a major health problem in westernized countries. However, a significant number of the morbidity and mortality resulting from these diseases could be prevented. Therefore, cardiovascular medicine has concentrated on prevention, early diagnosis and risk stratification in the recent years. Non-invasive imaging techniques are an essential tool in realizing this approach.

The application of both computed tomography (CT) and myocardial perfusion scintigraphy (MPS) in the evaluation of ischemic heart diseases are well established. High-resolution CT is generally used to evaluate cardio-vascular anatomy and to indentify coronary atherosclerosis, whereas, MPS is used to visualize cardiac perfusion patterns and to discriminate between normal, ischemic or infarcted regions within the myocardium. Therefore it is often stated that both imaging modalities provide complementary information for the diagnosis and stratification of patients with ischemic heart diseases. The integration of CT and MPS is known to improve the clinical decision-making in certain patient populations. These hybrid images do not have to be acquired on the same scanner, but can also be fused during post-processing of the data.

During this project, the students will work on a fusion tool that will create hybrid images by combining the MPS data with the high-resolution CT data using either Matlab or MeVisLab (has to be determined during the project). If a clinical applicable fusion tool is created within the duration of the project, and there is enough time left, a validation study using clinical patient data will also be conducted.


Datum: 8-12-2011

Naam indiener: B.J. de Wit – van der Veen

Handtekening indiener:

Gaarne dit formulier retourneren aan:

Universiteit Twente

Opleiding Technische Geneeskunde

Gebouw Noordhorst

Postbus 217

7500 AE Enschede