UTAlumni NetworkCalendarBergveld Lecture at the University of Twente

Bergveld Lecture at the University of Twente

The Bergveld lecture is a yearly lecture organized by the BIOS/Lab-on-a-Chip group in honour of Professor Piet Bergveld. The lecture of 2017 will be given at Thursday, 16 March 2017 at 15.30 (location:Amphitheater Vrijhof building), by the founding director of renowned WYSS-institute for Biologically Inspired Engineering (at Harvard University), prof.dr. Donald E. Ingber, M.D., Ph.D

  

See also: https://wyss.harvard.edu/team/executive-team/donald-ingber/

Explanation lecture

HUMAN ORGANS ON CHIPS AND PROGRAMMABLE NANOTHERAPEUTICS

In this presentation, I will describe work we have been carrying out at the Wyss Institute for Biologically Inspired Engineering at Harvard that I head, which leverages biological design principles to develop new engineering innovations.  I will highlight recent advances that my team has made in the engineering of “Organs-on-Chips”— microfluidic devices lined by living human cells created with computer microchip manufacturing techniques that recapitulate organ-level structure and functions as a way to replace animal testing for drug development, mechanistic discovery, and personalized medicine. I will review recent advances we have made in the engineering of multiple organ chips, including lung, gut, kidney, bone marrow, and blood-brain barrier chips, and in their use to develop human disease models and discover new therapeutics. I will also describe our efforts to integrate these organ chips into a ‘human body-on-chips’, and to engineer an automated instrument for real-time analysis of cellular responses to pharmaceuticals, chemicals, and toxins. I will also summarize other examples of bioinspired nanotechnologies in development at the Institute, including mechanically activated clot-busting nanotherapeutics that target to vascular occlusion sites like artificial platelets, and a dialysis-like ‘Biospleen’ device for cleansing blood of pathogens and toxins in patients with sepsis.

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