Flight and train
Enschede is easiest reached by flying into Amsterdam/ Schiphol International Airport, the largest airport in the Netherlands. An intercity train departs for Enschede directly from within the Schiphol terminal building every half hour, taking about 2 hours. Enschede is the final stop of the line. Note that only every other train goes directly to Enschede, with the others requiring a change in Amersfoort.
To find train schedules, use the NS train journey planner
to intercity hotel
When you arrive at the train station in Enschede, you will find the InterCity Hotel just 350 meters across the train station.
to Faculty ITC, University of Twente
To find your way to the ITC building, either by train or by car, take a look here.