Dutch technology foundation STW
Principal Investigator tracks
NeuroSIPE - Diagnostic tools for neurological disorders
The NeuroSipe Programme is a sustainable community and cooperation among Dutch universities, university medical centers, and companies, which aims to develop diagnostic tools for neurological disorders. The socio-economic impact of neurological disorders on society is huge, given the high incidence and prevalence. NeuroSIPE is unique in the sense that it focuses on a systems identification approach and not on a specific neurological disease or subsystem. Project description
The Movement Diagnostic System
Essential Tremor (ET), Parkinsonian tremor (PD) and limb dystonia are ubiquitous and disabling. Currently, diagnosis fails, especially in early disease stages, due to limited diagnostic tools. Targeted therapy is delayed, with a marked impact on disease outcome and progression. ET, PD and
dystonia are regarded to be diseases of the central nervous system (CNS), with pathological changes in different neuronal networks. This knowledge is hardly used in diagnosis, probably because neuronal networks are complex and situated deep in the brain. Functional MRI (fMRI) allows relating voluntary and involuntary movements directly with brain activity. Closed-loop system identification allows to asses the brain nuclei that are involved in motor control as well as the motor and sensory feedback loops that are hypothesized to play an important role in generating pathological brain activity.
Our goal is to develop a Movement Diagnostic System (MDS), a diagnostic system that captures abnormal brain activations in movement disorders patients. It will combine functional MRI, measures of muscle activity, video tracking devices and a wrist pertubator to manipulate the motor control systems.