Publications Amber
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2026
Article
Synthesis of an electrically conductive film and stimulation of neurons in a microfluidic platform integrated with ITO-coated PET electrodes (2026) Biosensors & Bioelectronics: X, 29 . Article 100744 . Coban, R. , Saskara, A. , Devamoglu, U. & Yesil-Celiktas, O. https://doi.org/10.1016/j.biosx.2026.100744 A Synovium-on-Chip Platform to Study Multicellular Interactions in Arthritis (2026) Advanced healthcare materials, 15(15) . Article e04857 . Spoelstra, L. R. , Semmekrot, F. R. , Araújo-Gomes, N. , Wijnperle, D. , Helsen, M. M. A. , Van Den Bosch, M. H. J. , Segerink, L. I. , Le Gac, S. & Karperien, M. https://doi.org/10.1002/adhm.202504857
2025
Article
Dual role of electrical stimulation and a biomimetic matrix in neural differentiation within a microfluidic platform (2025) Biomaterials Science, 13(13) , 3707-3721 . Devamoglu, U. , Arslan, Y. , Sabour-Takanlou, L. , Biray-Avci, C. & Yesil-Celiktas, O. https://doi.org/10.1039/d4bm01702a 3D Single-Molecule Super-Resolution Imaging of Microfabricated Multiscale Fractal Substrates for Calibration and Cell Imaging (2025) ACS Applied Materials & Interfaces, 17(6) , 9019–9034 . Cabriel, C. , Córdova-Castro, R. M. , Berenschot, E. , Dávila-Lezama, A. , Pondman, K. , Gac, S. L. , Tas, N. , Susarrey-Arce, A. & Izeddin, I. https://doi.org/10.1021/acsami.4c19431
Meeting Abstract
Joint-on-chip models: Opportunities and challenges in osteoarthritis research (2025) Orthopaedic proceedings, 107-B(SUPP_6) , 29-29 . Le Gac, S. https://doi.org/10.1302/1358-992X.2025.6.029
Poster
Studying the Role of Neuroblastoma-Derived Extracellular Vesicles in the Formation of a Pre-Metastatic Niche Using a Vessel-on-Chip Model (2025) [Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025 . Coindreau, G. , Markus, H. , Kocer, A. & Le Gac, S. Automated routing for fluidic and pneumatic channels in standardized microfluidic platforms using CAD software (2025) [Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025 . Spoelstra, L. R. , Kramer, M. , Karperien, M. , Le Gac, S. & Segerink, L. Evolution of vascular dysfunction under different fibrotic stages (2025) [Contribution to conference › Poster] 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems, µTAS 2025 . Devamoglu, U. , Streutker, E. M. , Verdurmen, W. P. R. & Le Gac, S. The Joint-on-Chip: A multi-Organ-on-Chip Model for Studying Inter-Tissue Crosstalk in Arthritis (2025) [Contribution to conference › Poster] 1st Dutch Osteoarthritis Research Day, OA Research Day NL . Spoelstra, L. R. , Semmekrot, F. R. , Serrano-Larrea, C. , Le, T. , Le Gac, S. , Segerink, L. & Karperien, M. On-Chip modelling of fibrosis-induced vasculopathy: From early dysregulation to further dysfunction (2025) [Contribution to conference › Poster] Microfluidics-Aided Technologies and Applications Conference, MaTA . Devamoglu, U. & Le Gac, S.
2024
Article
Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots (2024) Frontiers in Immunology, 15 . Kang, Y.-H. , Varghese, P. , Al Aiyan, A. , Pondman, K. , Kishore, U. & Sim, R. B. https://doi.org/10.3389/fimmu.2024.1368852
Editorial
The evolution of miniaturization, automation, and integration – a new scope for Lab on a Chip (2024) Lab on a chip, 24(6) , 1541-1541 . Article 24 . Wheeler, A. , Baret, J. C. , Cho, Y. K. , Herr, A. , Jiang, X. , Le Gac, S. , Lu, H. , Tokeshi, M. , Wu, H. , Garton, R. , Smallwood, A. , Lake, D. & Minhas, H. https://doi.org/10.1039/d4lc90015d
Poster
Exploring the influence of microenvironmental cues on vascular dynamics (2024) [Contribution to conference › Poster] 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2024 . Devamoglu, U. & Le Gac, S.
Preprint
3D single-molecule super-resolution imaging of microfabricated fractal substrates for cell culture and self-referenced imaging (2024) [Working paper › Preprint] . bioRxiv . Cabriel, C. , Córdova-Castro, R. M. , Berenschot, E. , Dávila-Lezama, A. , Pondman, K. , Le Gac, S. , Tas, N. , Susarrey-Arce, A. & Izeddin, I. https://doi.org/10.1101/2023.11.07.566090
Review article
Fibrosis-on-Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease (2024) Advanced healthcare materials, 13(21) . Article 2303991 . Streutker, E. M. , Devamoglu, U. , Vonk, M. C. , Verdurmen, W. P. R. & Le Gac, S. https://doi.org/10.1002/adhm.202303991
2023
Article
Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy (2023) Drug delivery and translational research, 13(5) , 1470-1483 . Priwitaningrum, D. L. , Pednekar, K. , Gabriël, A. V. , Varela-Moreira, A. A. , Gac, S. L. , Vellekoop, I. , Storm, G. , Hennink, W. E. & Prakash, J. https://doi.org/10.1007/s13346-023-01310-1 Nanoparticle-induced immune response: Health risk versus treatment opportunity? (2023) Immunobiology, 228(2) . Article 152317 . Pondman, K. , le Gac, S. & Kishore, U. https://doi.org/10.1016/j.imbio.2022.152317
Other
Single-molecule super-resolution imaging of microfabricated 3D substrates for 3D cell culture (Conference Presentation) (2023) [Contribution to conference › Other] SPIE BiOS 2023 . Cabriel, C. , Córdova-Castro, M. , Berenschot, E. , Dávila-Lezema, A. , Pondman, K. , Gac, S. L. , Tas, N. , Susarrey-Arce, A. & Izeddin, I. https://doi.org/10.1117/12.2648989
Poster
Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis (2023) [Contribution to conference › Poster] NanoBioTech Montreux 2023 . Spoelstra, L. R. , Araújo-Gomes, N. , Zakharova - Kolezhuk, M. , Welting, T. J. M. , Karperien, M. , Segerink, L. & Le Gac, S. Developing a lung-on-chip device for studying the impact of micro- and nanoplastics on human lung tissue (2023) [Contribution to conference › Poster] NanoBioTech Montreux 2023 . Mol, L. , Pondman, K. , Staal, Y. & Le Gac, S. Studying and improving the cytocompatibility of SLA resins (2023) [Contribution to conference › Poster] NanoBioTech Montreux 2023 . Bertelink, S. , Laffont, L. , Grasseau, I. , Reynaud, K. , Saint-Dizier, M. , Venzac, B. & Le Gac, S. Studying and improving the cytocompatibility of SLA resins (2023) [Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023 . Bertelink, S. , Laffont, L. , Grasseau, I. , Reynaud, K. , Saint-Dizier, M. , Venzac, B. & Le Gac, S. Elucidating the role of circulating tumor microemboli (CTM): applying organ-on-chip technology and in vitro models of homo- and heterotypic CTM (2023) [Contribution to conference › Poster] 6th Advances in Circulating Tumor Cells, ACTC 2023 . Faber, B. , Noll, M. , Le Gac, S. & Pondman, K. Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023) [Contribution to conference › Poster] 32nd NBTE Annual Meeting 2023 . Na, Y. , Devamoglu, U. , Le Gac, S. & Paez, J. Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023) [Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023 . Na, Y. , Devamoglu, U. , Le Gac, S. & Paez, J. Improving interfacial adhesion of hydrogel matrices to PDMS-based microfluidic platforms (2023) [Contribution to conference › Poster] TechMed Research Day 2023 . Na, Y. , Devamoglu, U. , Le Gac, S. & Paez, J. Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023) [Contribution to conference › Poster] NanoBioTech Montreux 2023 . Na, Y. , Devamoglu, U. , Le Gac, S. & Paez, J. Re-creating the vasculopathy observed in fibrotic diseases and systemic sclerosis (2023) [Contribution to conference › Poster] NanoBioTech Montreux 2023 . Devamoglu, U. & Le Gac, S.
2022
Article
Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip (2022) Lab on a chip, 22(9) , 1815-1828 . Paggi, C. A. , Hendriks, J. , Karperien, M. & Gac, S. L. https://doi.org/10.1039/D1LC01069G Joint-on-chip platforms: entering a new era of in vitro models for arthritis (2022) Nature reviews rheumatology, 18 , 217-231 . Paggi, C. A. , Moreira Teixeira, L. , le Gac, S. & Karperien, M. https://doi.org/10.1038/s41584-021-00736-6 Testis-on-chip platform to study ex vivo primate spermatogenesis and endocrine dynamics (2022) Organs-on-a-Chip, 4 . Article 100023 . Sharma, S. , Venzac, B. , Burgers, T. , Schlatt, S. & Le Gac, S. https://doi.org/10.1016/j.ooc.2022.100023
Conference contribution
Organs-on-chip for assisted reproductive technologies (2022) In 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2022 ) (pp. 11-12) . The Chemical and Biological Microsystems Society . Le Gac, S.
PhD Thesis - Research UT, graduation UT
Developing a joint-on-chip platform: A multi-organ-on-chip model to mimic healthy and diseased conditions of the synovial joints (2022) [Thesis › PhD Thesis - Research UT, graduation UT] . University of Twente . Paggi, C. A. https://doi.org/10.3990/1.9789036553261
Review article
Oxygen control: the often overlooked but essential piece to create better in vitro systems (2022) Lab on a chip, 22 , 1068-1092 . Palacio-Castaneda, V. , Velthuijs, N. , Le Gac, S. & Verdurmen, W. P. R. https://doi.org/10.1039/d1lc00603g La microfluidique au service de la médecine de la reproduction (2022) Medecine de la Reproduction, 24(1) , 50-61 . Le Gac, S. https://doi.org/10.1684/mte.2022.0876
2021
Article
Towards controlled bubble nucleation in microreactors for enhanced mass transport (2021) Reaction chemistry & engineering, 6(10) , 1869-1877 . Ripken, R. M. , Wood, J. A. , Schlautmann, S. , Günther, A. , Gardeniers, H. J. G. E. & Le Gac, S. https://doi.org/10.1039/d1re00092f Organosilicon uptake by biological membranes (2021) Communications Biology, 4(1) . Article 704 . Beekman, P. , Enciso-Martinez, A. , Pujari, S. P. , Terstappen, L. W. M. M. , Zuilhof, H. T. , Le Gac, S. & Otto, C. https://doi.org/10.1038/s42003-021-02155-5 A 3D polydimethylsiloxane microhourglass-shaped channel array made by reflowing photoresist structures for engineering a blood capillary network (2021) Methods, 190 , 63-71 . Rho, H. S. , Veltkamp, H.-W. , Baptista, D. , Gardeniers, H. , le Gac, S. & Habibović, P. https://doi.org/10.1016/j.ymeth.2020.03.007 PDMS Curing Inhibition on 3D-Printed Molds: Why? Also, How to Avoid It? (2021) Analytical chemistry, 93(19) , 7180-7187 . Venzac, B. , Deng, S. , Mahmoud, Z. , Lenferink, A. , Costa, A. , Bray, F. , Otto, C. , Rolando, C. & Le Gac, S. https://doi.org/10.1021/acs.analchem.0c04944
Comment/Letter to the editor
Endless forms fabricated (2021) Nature physics, 17(7) , 767-768 . Le Gac, S. https://doi.org/10.1038/s41567-021-01214-2 Author Correction: Organosilicon uptake by biological membranes (2021) Communications Biology, 4(1) . Article 812 . Beekman, P. , Enciso-Martinez, A. , Pujari, S. P. , Terstappen, L. W. M. M. , Zuilhof, H. , Le Gac, S. & Otto, C. https://doi.org/10.1038/s42003-021-02338-0 Publisher Correction: Organosilicon uptake by biological membranes (2021) Communications Biology, 4(1) . Article 813 . Beekman, P. , Enciso-Martinez, A. , Pujari, S. P. , Terstappen, L. W. M. M. , Zuilhof, H. , Le Gac, S. & Otto, C. https://doi.org/10.1038/s42003-021-02344-2
Conference contribution
A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system (2021) In MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 485-486) . The Chemical and Biological Microsystems Society . Paggi, C. A. , Araújo da Cunha Gomes, N. M. , Zuchowska, A. , Karperien, M. & le Gac, S. Cyclic exposure to compressive forces increases the differentiation efficiency of hipscs towards chondrocytes in a cartilage-on-chip platform (2021) In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 495-496) . van Dorp, T. , Paggi, C. A. , Slaats, R. H. , Schwach, V. , le Gac, S. , Passier, R. & Karperien, M. Investigating end-stage osteaorthitic cartilage and chondrosarcoma response to mechanical stimulation (2021) In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 429-430) . Paggi, C. A. , Porsul, I. R. , Plass, J. R. M. , Karperien, M. & Le Gac, S. Investigating the impact of mechanical stimulation on the aggressiveness of breast cancer (2021) In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 427-428) . Paggi, C. A. , Zuchowska, A. & le Gac, S. Rapid Organ-on-Chip vascularization activated by fibroblast aggregates (2021) In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 491-492) . Zuchowska, A. , Paggi, C. A. & le Gac, S. Studying the impact of nanoplastics on the integrity of the blood-epididymis barrier (2021) In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 497-498) . Stoimenou, E. , Pondman, K. , Burgers, T. , Venzac, B. , Sharma, S. , Schlatt, S. & le Gac, S. The presence of an ECM capsule around liver tumor models blocks the penetration of (Nano)-Drugs (2021) In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 637-638) . Zuchowska, A. , Bansal, R. & le Gac, S.
Editorial
Poster
An effective method to obtain an on-chip vascular network (2021) [Contribution to conference › Poster] NanoBioTech-Montreux 2021 . Zuchowska, A. , Paggi, C. A. & le Gac, S. Microplastics, the next threat to male fertility? (2021) [Contribution to conference › Poster] NanoBioTech-Montreux 2021 . Stoimenou, E. , Pondman, K. , Burgers, T. , Venzac, B. , Sharma, S. , Schlatt, S. & le Gac, S. A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system (2021) [Contribution to conference › Poster] 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 . Paggi, C. A. , Araújo da Cunha Gomes, N. M. , Zuchowska, A. , Karperien, M. & le Gac, S. Cyclic exposure to compressive forces increases the differentiation efficiency of hipscs towards chondrocytes in a cartilage-on-chip platform (2021) [Contribution to conference › Poster] 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 . van Dorp, T. , Paggi, C. A. , Slaats, R. H. , Schwach, V. , le Gac, S. , Passier, R. & Karperien, M. Investigating the impact of mechanical stimulation on the aggressiveness of breast cancer (2021) [Contribution to conference › Poster] 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 . Paggi, C. A. , Zuchowska, A. & le Gac, S. Rapid Organ-on-Chip vascularization activated by fibroblast aggregates (2021) [Contribution to conference › Poster] 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 . Zuchowska, A. , Paggi, C. A. & le Gac, S. Studying the impact of nanoplastics on the integrity of the blood-epididymis barrier (2021) [Contribution to conference › Poster] 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 . Pondman, K. , Stoimenou, E. , Burgers, T. , Venzac, B. , Sharma, S. , Schlatt, S. & le Gac, S. Influence of the spatial configuration of pericyte-like cells in the regulation of the formation of the vascular network (2021) [Contribution to conference › Poster] EUROoCS Annual conference 2021 . Zuchowska, A. , Paggi, C. A. & le Gac, S. Testis-on-a-chip platform to evaluate the impact of environmental plastic pollution on male fertility (2021) [Contribution to conference › Poster] EUROoCS Annual conference 2021 . Stoimenou, E. , Pondman, K. , Burgers, T. , Venzac, B. , Sharma, S. , Schlatt, S. & le Gac, S.
Review article
Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication (2021) Trends in biotechnology, 39(8) , 788-810 . Picollet-D'hahan, N. , Zuchowska, A. , Lemeunier, I. & Le Gac, S. https://doi.org/10.1016/j.tibtech.2020.11.014 Understanding and Assisting Reproduction in Wildlife Species Using Microfluidics (2021) Trends in biotechnology, 39(6) , 584-597 . le Gac, S. , Ferraz, M. , Venzac, B. & Comizzoli, P. https://doi.org/10.1016/j.tibtech.2020.08.012
2020
Article
Programmable droplet-based microfluidic serial dilutor (2020) Journal of Industrial and Engineering Chemistry, 91 , 231-239 . Rho, H. S. , Yang, Y. S. , Terstappen, L. W. M. M. , Gardeniers, H. , Le Gac, S. & Habibovic, P. https://doi.org/10.1016/j.jiec.2020.08.004 Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage (2020) Sensors and Actuators B: Chemical, 315 . Article 127917 . Paggi, C. A. , Venzac, B. , Karperien, M. , Leijten, J. & le Gac, S. https://doi.org/10.1016/j.snb.2020.127917 Cancer-ID: Toward identification of cancer by tumor-derived extracellular vesicles in blood (2020) Frontiers in oncology, 10 . Article 608 . Rikkert, L. G. , Beekman, P. , Caro, J. , Coumans, F. A. W. , Enciso-Martinez, A. , Jenster, G. , Le Gac, S. , Lee, W. , van Leeuwen, T. G. , Loozen, G. B. , Nanou, A. , Nieuwland, R. , Offerhaus, H. L. , Otto, C. , Pegtel, D. M. , Piontek, M. C. , van der Pol, E. , de Rond, L. , Roos, W. H. , … Terstappen, L. W. M. M. https://doi.org/10.3389/fonc.2020.00608 Metabolic Switching of Tumor Cells under Hypoxic Conditions in a Tumor-on-a-chip Model (2020) Micromachines, 11(4) . Article 382 . Valentina, P.-C. , Kooijman, L. J. , Venzac, B. , Wouter, V. & Le Gac, S. https://doi.org/10.3390/mi11040382 Electrochemical Detection of Tumor-Derived Extracellular Vesicles on Nanointerdigitated Electrodes (2020) Nano letters, 20(2) , 820-828 . Mathew, D. G. , Beekman, P. , Lemay, S. G. , Zuilhof, H. , le Gac, S. & van der Wiel, W. G. https://doi.org/10.1021/acs.nanolett.9b02741 A dog oviduct-on-a-chip model of serous tubal intraepithelial carcinoma (2020) Scientific reports, 10(1) . Article 1575 . de Almeida Monteiro Melo Ferraz, M. , Nagashima, J. B. , Venzac, B. , Le Gac, S. & Songsasen, N. https://doi.org/10.1038/s41598-020-58507-4 3D printed mold leachates in PDMS microfluidic devices (2020) Scientific reports, 10(1) . Article 994 . Ferraz, M. , Nagashima, J. B. , Venzac, B. , le Gac, S. & Songsasen, N. https://doi.org/10.1038/s41598-020-57816-y
Chapter
Cytochrome P450 (CYP) (2020) In Handboek medische laboratoriumdiagnostiek (pp. 248-251) . Prelum Uitgevers . Pondman, K. M. Farmacogenetica (2020) In Handboek medische laboratoriumdiagnostiek (pp. 298-298) . Prelum Uitgevers . Pondman, K. M.
Conference contribution
Mechanical stimulation increases ECM production by chondrocytes in a cartilage-on-a-chip platform (2020) In Proceedings of the 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 . Article T4-454.e . Paggi, C. A. , Hendriks, J. , Moreira Teixeira Leijten, L. S. , Karperien, M. & le Gac, S. Modelling the tumor micro-environment in hepatocellular carcinoma using multi-cellular spheroids (2020) In Proceedings of MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 937-938) (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences) . The Chemical and Biological Microsystems Society . Ortiz-Perez, A. , Zuchowska, A. , Blondé, J. B. , Bansal, R. & Le Gac, S. Multi-modal analysis of tumor-derived extracellular vesicles immunocaptured from plasma (2020) In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 404-405) (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences) . The Chemical and Biological Microsystems Society . Beekman, P. , Enciso-Martinez, A. , Piontek, M. , Terstappen, L. , Roos, W. , Otto, C. & Le Gac, S. Organosilicon interaction with biological membranes (2020) In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1035-1036) . The Chemical and Biological Microsystems Society . Beekman, P. , Enciso-Martinez, A. , Pujari, S. , Zuilhof, H. , Terstappen, L. , Otto, C. & Le Gac, S. Synovial membrane on chip: a new tool to study co-culture response to mechanical stimulation (2020) In Proceedings of the 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 . Article Th8-854.e . Paggi, C. A. , Zakharova, M. , Segerink, L. , le Gac, S. , Moreira Teixeira Leijten, L. S. & Karperien, M. Why are 3D-printed molds inhibiting PDMS curing? (2020) In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 282-283) . The Chemical and Biological Microsystems Society . Venzac, B. , Deng, S. , Mahmoud, Z. , Lenferink, A. , Bray, F. , Otto, C. , Rolando, C. & Le Gac, S.
Other
Ex-vivo culture of testis and epididymis tissues in a microfluidic devices (2020) [Contribution to conference › Other] 17th International Conference of Biomedical Engineering, ICBME 2019 . Venzac, B. , Burgers, T. , Schlatt, S. & Sharma, S.
Paper
Welcome to the 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences! (2020) [Contribution to conference › Paper] 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 . Le Gac, S. & Lu, H.
Patent
Sensor for single particle detection (2020) [Patent › Patent] . University of Twente . Mathew, D. G. , Beekman, P. , van der Wiel, W. G. & Lemay, S. J. G. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020178408&tab=PCTBIBLIO
2019
Abstract
Highly sensitive detection of tumor-derived extracellular vesicles using an enzymatic assay and redox cycling (2019) [Contribution to conference › Abstract] 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 . Mathew, D. G. , Beekman, P. , Lemay, S. G. , Le Gac, S. & van der Wiel, W. A modular joint-on-chip approach to study cellular cross-communication in a simulated osteoarthritic micro-environment (2019) [Contribution to conference › Abstract] TERMIS European Chapter Meeting 2019 . Moreira Teixeira, L. , Paggi, C. , Piluso, S. , Leijten, J. , Malda, J. , van Weeren, R. , le Gac, S. & Karperien, M.
Article
Aqueous-Phase Reforming in a Microreactor: The Role of Surface Bubbles (2019) Chemical engineering and technology, 42(10) , 2179-2186 . Ripken, R. M. , Wood, J. A. , Gardeniers, J. G. E. & Le Gac, S. https://doi.org/10.1002/ceat.201900142
Conference contribution
Highly sensitive detection of tumor-derived extracellular vesicles using an enzymatic assay and redox cycling (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 . The Chemical and Biological Microsystems Society . Beekman, P. Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain (2019) In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 406-407) . The Chemical and Biological Microsystems Society . Paggi, C. A. , Venzac, B. , Leijten, J. , Leijten, L. M. T. , Karperien, M. & Le Gac, S.
Paper
3D model of liver cancer in vitro as a tool to evaluate nanomedicines (2019) [Contribution to conference › Paper] NanoBioTech-Montreux 2019 . Ortiz Perez, A. , Blondé, J.-B. G. M. , Bansal, R. & le Gac, S.
Poster
Immunocapturing of tumor-derived extracellular vesicles on micropatterned and antibody-conjugated surfaces for individual correlative light, probe and electron measurements (2019) [Contribution to conference › Poster] 8th Congress of the International Society for Extracellular Vesicles, ISEV 2019 . Beekman, P. Electrochemical quantification of EVs at physiological concentrations (2019) [Contribution to conference › Poster] 8th Congress of the International Society for Extracellular Vesicles, ISEV 2019 . Beekman, P. Epididymis-on-a-chip: a valuable research tool to study tight barriers, sperm maturation and to screen endocrine disruptors (2019) [Contribution to conference › Poster] NanoBioTech-Montreux 2019 . Burgers, T. , Venzac, B. , Jafek, A. , Sharma, S. , Schlatt, S. & le Gac, S. On-line impedimetric monitoring of single cell electrical lysis in a microfluidic device (2019) [Contribution to conference › Poster] 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 . Sukas, S. , van den Berg, A. , Terstappen, L. & le Gac, S. PDMS curing inhibition by 3D-printed templates. Why? And how to avoid it (2019) [Contribution to conference › Poster] NanoBioTech-Montreux 2019 . Venzac, B. , le Gac, S. , Otto, C. & Lenferink, A. T. M. PDMS curing inhibition by 3D-printed templates. Why? And how to avoid it (2019) [Contribution to conference › Poster] 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 . Venzac, B. , le Gac, S. , Yang, S. , Lenferink, A. T. M. & Otto, C. Shear-free and robust trapping of oocytes in an oviduct-on-chip. (2019) [Contribution to conference › Poster] NanoBioTech-Montreux 2019 . Venzac, B. , le Gac, S. , Gadella, B. & Henning, H. H. W.
2018
Conference contribution
Tumour-on-a-chip platform to evaluate nanoparticles penetration in 3D co-culture tumour spheroids (2018) In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1959-1960) . The Chemical and Biological Microsystems Society . Blondé, J.-B. , Priwitaningrum, D. , Prakash, J. & le Gac, S. A microfluidic droplet serial dilutor with enhanced mixing (2018) In MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1114-1115) . The Chemical and Biological Microsystems Society . Rho, H. S. , Yang, Y. , Terstappen, L. W. M. M. , Habibović, P. & le Gac, S. Controlled bubble nucleation in gas-liquid-solid catalytic microsystems for enhanced mass transport (2018) In MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 409-410) . The Chemical and Biological Microsystems Society . Ripken, R. M. , Wood, J. A. , Schlautmann, S. , Günther, A. , Gardeniers, J. G. E. & le Gac, S. Immunocapturing of extracellular vesicles on stainless steel for multi-modal individual characterization with correlative light, electron and probe microscopy (2018) In MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2402-2403) . The Chemical and Biological Microsystems Society . Beekman, P. , Enciso Martinez, A. , Terstappen, L. , Otto, C. & le Gac, S. Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation (2018) In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1620-1621) . The Chemical and Biological Microsystems Society . Bokkers, A. M. , Blondé, J.-B. , Lentacker, I. , Versluis, M. , Lajoinie, G. & Le Gac, S.
2017
Chapter
Electroporation in microfluidic devices (2017) In Handbook of Electroporation (pp. 1339-1358) . Springer . Le Gac, S. & van Uitert, I. https://doi.org/10.1007/978-3-319-32886-7_136
2016
Article
Polymer phase transition in n-lauryl methacrylate monoliths (2016) Polymer international, 65(6) , 706-712 . Dembahri, Z. , Le Gac, S. , Tobal, K. , Chirani, N. , Rolando, C. , Benmouna, F. & Benmouna, M. https://doi.org/10.1002/pi.5123 A Microfluidic Device with Continuous Ligand Gradients in Supported Lipid Bilayers to Probe Effects of Ligand Surface Density and Solution Shear Stress on Pathogen Adhesion (2016) Advanced materials interfaces, 3(9) . Article 1600055 . Van Weerd, J. , Sankaran, S. , Roling, O. , Krabbenborg, S. , Huskens, J. , Le Gac, S. , Ravoo, B. J. , Karperien, M. & Jonkheijm, P. https://doi.org/10.1002/admi.201600055
Conference contribution
Drug screening on 3D tumor spheroids (2016) In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) (pp. 45-46) . The Chemical and Biological Microsystems Society . Le Gac, S.
Review article
A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models (2016) Trends in biotechnology, 34(9) , 757-769 . Picollet-D'hahan, N. , Dolega, M. E. , Liguori, L. , Marquette, C. , Le Gac, S. , Gidrol, X. & Martin, D. K. https://doi.org/10.1016/j.tibtech.2016.06.012
2007
Conference contribution
Synthesis, functionalization and characterization of rod-shaped gold nanoparticles as potential optical contrast agents (2007) In European Conference on Biomedical Optics, ECBO 2007 (Optics InfoBase Conference Papers) . Optical Society of America . Rayavarapu, R. G. , Petersena, W. , Le Gac, S. , Ungureanu, C. , Van Leeuwen, T. G. & Manohara, S.