Aim / Objective:
The Health Preference Research Group of the University of Twente consists of a team of academics with a specific interest in the perspective of stakeholders (e.g. patients, physicians, payers) on health care innovation, and the role of stakeholder values, preferences and needs into decisions as they are made in health care. This includes decisions with regard to the development of new health care innovations, the evaluation of current health care services, shared patient clinician decision making and macro decisions on reimbursement and access of new drugs and devices to the mark. On this page you can find:
- the profiles of the academics of the Health Preference Research Group
- why stated preference research can be of
- the variety of stated preference techniques we have experience with and examples of research questions we can answer
- our contact information
Please feel free to contact us, and have a talk about your research question and whether stated preference research would be a solution.
University of Twente - Health Preference Group
T: +31 53 489 5410
University of Twente
Drienerlolaan 5, 7522 NB Enschede
Building Ravelijn (on the campus, no. 10 on the map)
- Are specifically relevant to quantify value with regard to aspects of health and health care that are not picked up by HrQoL measures (such as process of care, waiting time)
- Are increasingly being recognized as a potential source of evidence for national HTA agencies and FDA and EMA in benefit-risk projects.
- Are increasingly used to assist patients in choosing their preferred treatment and/or diagnostic trajectory in clinical (shared) decision making
- Help to evaluate and adjust new technologies and medical devices before they enter the market (early HTA).
Examples of research questions we are able answer are:
- What are stakeholder preferences for characteristics of a medical device (in development)?
- What is important to patients when deciding about breast cancer screening?
- Which attributes of treatment are most important to patients in order to stimulate adherence to anticoagulant therapy?
- What is the willingness-to-pay for future health benefits among hypertensive patients?
- What is the impact of physician preferences on the prescription of a new drug?
Our research techniques:
- Systematic literature reviews
- In-depth interviews
- Multi-Criteria Decision Analysis Methods (such as analytical hierarchy process, MacBeth)
- Conjoint Analysis (discrete choice experiments, best-worst scaling)
- Public payers
- Industry: pharmaceutical companies
The different research techniques can be combined to come up with a practical answer to real-world questions and problems. The choice of technique depends on the clinical question to be answered and the size of the stakeholder population.
Meet our core team of academics at the University of Twente with an interest in health preference research:
Maarten IJzerman is a full professor in the department Health Technology & Services Research at the University of Twente, the Netherlands. He is the deputy dean for Health & Biomedical Technology in the Faculty for Science and Technology, overseeing the health related programs at the University of Twente. Maarten’s main interest is technological innovation in healthcare. Most of his current work is on the application of outcomes research and decision analytic models to evaluate the health economic impact of diagnostic and imaging technologies for personalizing healthcare, in particular oncology. He is one of pioneers in the field of early Health Technology Assessment, a research program to determine the added value of new medical technologies in development. A specific methodological contribution is the use of multi-criteria decision models and conjoint analysis to value health services and to elicit stakeholder- and patient preferences for health outcomes and technology. He has more than 150 peer-reviewed articles in the intersection of engineering, medicine and outcomes research.
Between September 2013 and May 2014 he was the acting scientific director of the MIRA Institute for Biomedical Technology and Technical Medicine. Maarten IJzerman is a visiting adjunct professor at Case Western Reserve University in Cleveland (USA), a visiting research scientist at the Luxembourg Institute of Health and the University Medical Center Groningen.
The value of your answers depends on the validity of the questions you are asking. The construct validity of the results of stated preference surveys and multi-criteria decision analyses depend on the operationalization of research questions into questions that have face validity to patients. For the last 10 years, Janine van Til has developed her expertise in doing just that. She is a health scientist by training, but started her work in preference research during her PhD, which was focused on integrating patient and clinician values in clinical decision making. Janine is working as an assistant professor in the department of Health Technology and Services Management at the University of Twente in the Netherlands. Her research is focused on using preference methods, mainly discrete choice experiments, best-worst scaling and multi-criteria decision analysis to include the stakeholder perspective in health care decisions in the clinical, management and societal context. Among others, she is projectleader in a ZonMW funded project from HTA-methodology on determining patient preferences for the process of drug use in Parkinson’s Disease, was an external supervisor in a project from KCE (Belgian health care knowledge centre) on elicitating societal preferences for reimbursement decision criteria with DCEs, and is currently contributing to MOCHA, a large EU funded project that will appraise the differing models of child health that are used across Europe.
Karin Groothuis-Oudshoorn, PhD is an assistent professor of biostatistics in the department of Health Technology & Service Research. She has 15 years of experience as registered biostatistician in health services research. Currently, she is a program leader of development and statistical analysis of discrete choice experiments and multi-criteria decision models. As regards to methodology development, she was a member of the patient preference task force working group of the international society of pharmacoeconomics and outcomes research (ISPOR), that aimed to write a guideline on statistical analysis and reporting of conjoint analysis. Among others, she was currently involved in a ZonMW funded project from HTA-methodology on determining patient preferences for the process of drug use in Parkinson’s Disease. She was an external advisor in a project from KCE (Belgian health care knowledge centre) on elicitating societal preferences for reimbursement decision criteria with DCEs and in preferences studies from the Dutch Institute for Public Health and Environment. She is projectleader from the ZonMw project: ‘A roadmap for uncertainty in MCDA’ (in corporation with the Dutch Health care Insurance Board). Also she is a member of the Ethical Committee of Twente.
More insight into patient’s preferences for medical interventions and treatments is needed as a response to the strong push towards personalized medicine as well as dealing with scarcity in the allocation of healthcare resources. In the last four years the PhD research of Marieke Weernink has contributed to these issues in Parkinson’s Disease and prostate cancer. Using validated preference elicitation techniques such as discrete choice experiment, best-worst scaling and multi-criteria decision analysis the perspective of the patient on health care innovations and aspects of treatment was revealed. Additionally, Marieke Weernink addressed methodological issues focusing on designing, modelling and validation of preference techniques in health care.
- Junior researcher
- office manager
- Dijk, Joris D. van and Groothuis-Oudshoorn, Catharina G.M. and Marshall, Deborah A. and IJzerman, Maarten J. (2016) An Empirical Comparison of Discrete Choice Experiment and Best-Worst Scaling to Estimate Stakeholders’ Risk Tolerance for Hip Replacement Surgery. Value in health, 19 (4). pp. 316-322. ISSN 1098-3015
- Hauber AB, González JM, Groothuis-Oudshoorn CGM, Prior T, Marshall DA, Cunningham C, IJzerman MJ, Bridges, JPF. Statistical Methods for the Analysis of Discrete Choice Experiments: A Report of the ISPOR Conjoint Analysis Good Research Practices Task Force. Value Health. 2016;19(4):300-15.
- Thokala, Praveen and Devlin, Nancy and Marsh, Kevin and Baltussen, Rob and Boysen, Meindert and Kalo, Zoltan and Longrenn, Thomas and Mussen, Filip and Peacock, Stuart and Watkins, John and IJzerman, Maarten (2016) Multiple Criteria Decision Analysis for Health Care Decision Making—An Introduction: Report 1 of the ISPOR MCDA Emerging Good Practices Task Force. Value in health, 19 (1). 1 - 13. ISSN 1098-3015
- Marsh, Kevin and IJzerman, Maarten and Thokala, Praveen and Baltussen, Rob and Boysen, Meindert and Kalo, Zoltan and Longrenn, Thomas and Mussen, Filip and Peacock, Stuart and Watkins, John and Devlin, Nancy (2016) Multiple Criteria Decision Analysis for Health Care Decision Making—Emerging Good Practices: Report 2 of the ISPOR MCDA Emerging Good Practices Task Force. Value in health, 19 (2). 125 - 137. ISSN 1098-3015
- Weernink, Marieke G.M. and Groothuis-Oudshoorn, Catharina G.M. and IJzerman, Maarten J. and Til, Janine A. van (2016) Valuing Treatments for Parkinson Disease Incorporating Process Utility: Performance of Best-Worst Scaling, Time Trade-Off, and Visual Analogue Scales. Value in health, 19 (2). 226 - 232. ISSN 1098-3015
- Weernink, M. G. M., van Til, J. A., van Vugt, J. P. P., Movig, K. L. L., Groothuis-Oudshoorn, C. G. M., & IJzerman, M. J. (2016). Involving Patients in Weighting Benefits and Harms of Treatment in Parkinson's Disease. PLoS One, 11(8), e0160771. doi:10.1371/journal.pone.0160771
- Broekhuizen, H. and Groothuis-Oudshoorn, C.G.M. and Til, J.A. van and Hummel, J.M. and IJzerman, M.J. (2015) A Review and Classification of Approaches for Dealing with Uncertainty in Multi-Criteria Decision Analysis for Healthcare Decisions. PharmacoEconomics, 33 (5). 445 - 455. ISSN 1170-7690
- Broekhuizen, Henk and Groothuis-Oudshoorn, Catharina G.M. and Hauber, A. Brett and Jansen, Jeroen P. and IJzerman, Maarten J. (2015) Estimating the value of medical treatments to patients using probabilistic multi criteria decision analysis. BMC medical informatics and decision making, 15 . 102 -. ISSN 1472-6947
- Weernink, Marieke G.M. and Janus, Sarah I.M. and Til, Janine A. van and Raisch, D.W. and Manen, Jeannette G. van and IJzerman, Maarten J. (2014) A Systematic Review to Identify the Use of Preference Elicitation Methods in Healthcare Decision Making. Pharmaceutical medicine, 28 (4). 175 - 185. ISSN 1178-2595
- Til, Janine van and Groothuis-Oudshoorn, Catharina and Lieferink, Marijke and Dolan, James and Goetghebeur, Mireille (2014) Does technique matter; a pilot study exploring weighting techniques for a multi-criteria decision support framework. Cost effectiveness and resource allocation, 12 (22). ISSN 1478-7547
- Weernink, M. G. M., Groothuis-Oudshoorn, C. G. M., Ijzerman, M. J., & van Til, J. A. Risky decision making in Best-Worst Scaling. In: Seminar Using Stated Preference methods in Health and Public Health, 9-10 April 2015, Bilthoven.
- Weernink, M. G. M., Groothuis-Oudshoorn, C. G. M., van Til, J. A. & Ijzerman, M. J. Framing of attribute’s levels: influence on the valuation and interpretation of outcomes from a best-worst scaling experiment. In: 3rd meeting of the International Academy Health Preference Research, 18 October 2015, Saint Louis.
- Vaanholt, M., Weernink, M. G. M., Von Birgelen, C. & van Til, J. A. Are component endpoint equal? A study into the practice of composite end point in clinical trials. ISPOR 19th Annual European Congress,31 October – 2 November 2016, Vienna.
- Groothuis-Oudshoorn, C. G. M., Weernink, M. G. M., van Til, J. A, Flynn, TN. Within person comparison of a profile and multi-profile best worst scaling for Parkinson's treatment. In: 4th meeting of the International Academy Health Preference Research, 12 July 2016, Hamburg.
- Fens, A, Weernink, M. G. M., Von Birgelen, C., van Til, J. A. Patient Preferences for Radial versus Femoral Vascular Access Options in Coronary Angiography and Intervention. In: 3rd meeting of the International Academy Health Preference Research, 18 October 2015, Saint Louis.
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