Prof. Jan de Boer, PhD


Prof. Jan de Boer, PhD

ZH132 (Zuidhorst)


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Personal information

Jan de Boer studied biology at Utrecht University. After obtaining his PhD in the lab of Jan Hoeijmakers at the Erasmus MC in 1999 on mouse models for premature ageing, he worked as a postdoc at the MRC Laboratory of Molecular Biology in Cambridge, UK. In 2002, he started as a research associate at IsoTis B.V. in Bilthoven where his research focused on bone tissue engineering, with special emphasis on the use of stem cells. In December 2003, de Boer obtained a position as associate professor at the University of Twente, MIRA Institute for Biomedical Technology and Technical Medicine. In 2007, a VIDI project was awarded on endothelial differentiation of human mesenchymal stem cells which is within the current scope of his research on molecular and cellular engineering of bone tissue.

He is chairman of the Netherlands Society of Biomaterials and Tissue Engineering (NBTE), editorial board member of Current Stem Research & Therapy and the Open Biomedical Engineering Journal and co-founder of the biotech company Materiomics B.V.

Selected publications

Unadkat, H.V., Hulsman, M., Cornelissen, K., Papenburg, B., Truckenmüller, R.K., Post, G.F., Uetz, M., Reinders, M.J.T., Stamatialis, D., van Blitterswijk, C.A. and de Boer, J. An algorithm-based topographical biomaterials library to instruct cell fate. Proc Natl Acad Sci USA 108(40):16565-70.

Jukes JM, Both SK, Leusink A, Sterk LM, van Blitterswijk CA, de Boer J. Endochondral bone tissue engineering by embryonic stem cells. (2008) Proc. Nat. Acad. Sci. USA 105(19):6840-5.

Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J. Activation of cAMP/PKA signalling in human mesenchymal stem cells in vitro results in robust bone formation in vivo. (2008) Proc. Nat. Acad. Sci. USA 105:7281-7286

Yuan, H., Fernandes, H. Habibovic, P., de Boer, J., Barradas, A., Walsh, W., van Blitterswijk, C.A. and de Bruijn, J. Osteoinductive ceramics as a synthetic alternative to autologous bone grafting Proc Natl Acad Sci USA 107(31):13614-9.

Alves, H.A., Munoz-Najar, U., de Wit,J., Renard, A., Hoeijmakers, J.H.J., Sedivy, J.M., van Blitterswijk, C.A. and de Boer, J. A link between the accumulation of DNA damage and loss of multipotency of human mesenchymal stromal cells J. of Cell and Mol. Med. 14(12):2729-38.

de Boer, J., Andressoo, J.O., de Wit, J., Huijmans, J., Beems, R.B., van Steeg, H., Weeda, G., van der Horst, G.T.J., van Leeuwen, W., Themmen, A.P.N., Meradji, M. and Hoeijmakers, J.H.J. (2002) Premature ageing in mice deficient in DNA repair and transcription. Science, 296, 1276-1279.