Patents

1.

Methods and algorithms for cell enumeration in a low-cost cytometer. Inventors: Droog, E. Tibbe, A. Greve, J. Gohel, D. Terstappen, L. United States Patent: 7,943,397 May 17, 2011.

2.

A Method For Assessing Disease States By Profile Analysis of Isolated Circulating Endothelial Cells. Inventors: Mark Connelly, Gerald V. Doyle, Galla Chandra Rao, Leon W.M.M. Terstappen. United States Patent: 7,901,950. March 8, 2011.

3.

Analysis of Circulating Tumor Cells, Fragments, and Debris Inventors: Galla Chandra Rao, Christopher Larson, Madeline Repollet, Herman Rutner, Leon WMM Terstappen, Shawn Mark O’Hara, Steven Gross. United States Patent 7,863,012 B2, January 4, 2011.

4.

Method and apparatus for imaging target components in a biological sample using permanent magnets. Inventors: Arjan GJ Tibbe, Leon WMM Terstappen. United States Patent No: 7,828,968 B2, November 9, 2010.

5.

Method and algorithms for cell enumeration in low-cost cytometer. Inventors: Coumans FAW, Greve J, Modica F, Greve J, Modica F, Terstappen LWMM, Tibbe A,Verrant J. United States Patent No: 7,764,821 B2, July 27, 2010.

6.

Method and apparatus for imaging target components in a biological sample using permanent magnets. Inventors: Arjan GJ Tibbe, Leon WMM Terstappen. United States Patent No: 7,828,968 B2, November 9, 2010.

7.

Magnetic separation apparatus and methods. Inventors: Tycho M Scholtens, Leon WMM Terstappen, Arjan GJ Tibbe. United States Patent No: 7,666,308 B2, February 23, 2010

8.

Methods and reagents for the rapid and efficient isolation of circulating tumor cells. Inventors: Leon WMM Terstappen, Galla Chandra Rao, Jonathan W. Uhr, Emillian V. Racilla, Paul A Liberti United States Patent No: 7,332,288 B2, February 18, 2008

9.

Devices and methods to image objects. Inventors: Arjan Tibbe,Jan Greve, Leon WMM Terstappen, Bart De Grooth United States Patent No: 7,282,180 B2, October 16, 2007

10.

Magnetic separation apparatus and methods. Inventors: Leon WMM Terstappen, GJ Dolan United States Patent No: 6,890,426 B2, May 10, 2005 Apparatus and methods for magnetic separation Inventors: Leon WMM Terstappen, Gerald V Doyle, Paul A Liberti, Gerald J Dolan United States Patent No: 7,056,657 B2, June 6, 2006

11.

Method for analysis of cellular components of a fluid. Inventors: LWMM Terstappen, MR Loken United States Patent No: 5,047,321, September 10, 1991 European Patent No: 347210

12.

Phage antibodies Inventors: Leon WMM Terstappen, Ton Logtenberg United States Patent No: 6,858,384 B2, February 22, 2005

13.

Magnetic separation apparatus and methods. Inventors: Leon WMM Terstappen, GJ Dolan United States Patent No: 6,790,366 B2, September 14, 2004

14.

Increased separation efficiency via controlled aggregation of magnetic nanoparticles Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti United States Patent No: 6,551,843 B1, April 22, 2003

15.

Methods for enhancing binding interactions between members of specific binding pairs. Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti United States Patent No: 6,623,982 B1, September 23, 2003

16.

Increased separation efficiency via controlled aggregation of magnetic nanoparticles. Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti United States Patent No: 6,620,627 B1, September 16, 2003

17.

Apparatus and methods for capture and analysis of particulate entities. Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti United States Patent No: 6,623,983 B1, September 23, 2003

18.

Methods and reagents for the rapid and efficient isolation of circulating tumor cells. Inventors: Leon WMM Terstappen, Galla Chandra Rao, Jonathan W. Uhr, Emillian V. Racilla, Paul A Liberti United States Patent No: 6,645,731 B2, November, 2003

19.

Magnetic separation apparatus and methods. Inventors: Leon WMM Terstappen, GJ Dolan United States Patent No: 6,660,159 B1, December 9, 2003

20.

Method to distinguish hematopoietic progenitor cells Inventors: Johanna Olweus, Fridtjof Lund-Johansen, Leon WMM Terstappen United States Patent No: 6,555,324 B1, April 29, 2003

21.

Apparatus and methods for magnetic separation. Inventors: Leon WMM Terstappen Gerald V. Doyle, Paul A. Libert, Gerald J. Dolan United States Patent No: 6,361,749, March 26, 2002

22.

Methods and reagents for the rapid and efficient isolation of circulating tumor cells. Inventors: Leon WMM Terstappen, Galla Chandra Rao, Jonathan W. Uhr, Emillian V. Racilla, Paul A Liberti United States Patent No: 6,365,362, April 2, 2002

23.

Method to select and transfect cell subpopulations Inventor: Leon WMM Terstappen United States Patent No: 6,228,624 B1, May 8, 2001

24.

Phage antibodies. Inventors: Leon WMM Terstappen, Ton Logtenberg United States Patent No: 6,265,150 B1, July 24, 2001

25.

Multidimensional cell differential analysis. Inventors: Leon WMM Terstappen, Chia-Huei Chen United States Patent No: 6,287,791 B1, Sept 11, 2001

26.

Methods for biological substance analysis employing internal magnetic gradients separation and an externally-applied transport force. Inventors: Terstappen, Leon W. M. M.; Liberti, Paul A. United States Patent No: 6,013,188, January 11, 2000

27.

Magnetic devices and sample chambers for examination and manipulation of cells. Inventors: GJ Dolan, Leon WMM Terstappen United States Patent No: 6,136,182, October 24, 2000

28.

Magnetic Separation Apparatus and Methods Employing an Internal Magnetic Capture Gradient and an External Transport Force. Inventors: GJ Dolan, Leon WMM Terstappen United States Patent No: 5,985,153, November 16, 1999

29.

Quantitative cell analysis methods employing magnetic separation Inventors: Terstappen, Leon W. M. M.; Liberti, Paul A. United States Patent No: 5,993,665, November 30, 1999

30.

Assay of blood or other biologic samples for target analytes. Inventors: RA Levine, SC Wardlaw, LWMM Terstappen United States Patent No: 5,776,710, July 7, 1998

31.

Assay of blood or other biological samples for target analytes. Inventors: RA Levine, SC Wardlaw, LWMM Terstappen United States Patent No: 5,834,217, November 10, 1998

32.

Phenotypic characterization of the hematopoietic stem cell. Inventors: LWMM Terstappen United States Patent No: 5,840,580, November 24, 1998

33.

T Lymphocyte precursor. Inventors: Leon WMM Terstappen, Louis J Picker United States Patent No: 5,622,853, 1997

34.

Automatic lineage assignment of acute leukemias by flow cytometry. Inventors: Leon WMM Terstappen, Ben JH Verwer United States Patent No: 5,605,805, 1997

35.

Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof. Inventors: LWMM Terstappen, CC Rao, DL Gohel, B Feeley, Gross S, Church E, Liberti P United States Patent No: 5,646,001, July 8, 1997

36.

New population of human progenitor stem cells - lack CD38 but express CD34 and are used in bone marrow transplantation and gene therapy. Inventors: M Loken, LWMM Terstappen European Patent No: 455482 , 1996

37.

T Lymphocyte precursor. Inventors: Leon WMM Terstappen, Louis J Picker United States Patent No: 5,583,033, 1996

38.

Indirect fluorescent assay of blood samples. Inventors: RA Levine, SC Wardlaw, LWMM Terstappen, TJ Mercolino, Recktenwald DJ. United States Patent No: 5,460,979, Oct. 24, 1995

39.

Apparatus for indirect fluorescent assay of blood samples. Inventors: RA Levine, SC Wardlaw, LWMM Terstappen, TJ Mercolino, Recktenwald DJ United States Patent No: 5,342,790, Aug. 30, 1994 European Patent Application No: 595641

40.

Method for the classification and monitoring of leukemias. Inventor: Leon WMM Terstappen United States Patent No: 5,234,816, Aug. 10, 1993

41.

Method for data transformation. Inventors: RA Mickaels, RK Dost, LWMM Terstappen, MR Loken United States Patent No: 5,224,058, June 29, 1993 European Patent Application No: 455392

42.

Method for discriminating between intact and damaged cells in a sample. Inventors: LWMM Terstappen, MR Loken. United States Patent No: 5,057,413, October 15, 1991. European Patent No: 347039

43.

Particle discriminator and method. Inventors BG de Grooth, J Greve, LWMM Terstappen United States Patent No: 5,017,497, May 21,1991 DE 3712862 C2 960711