Bottom-up nanopatterning
Exploring combinations of top-down and bottom-up nanopatterning techniques to achieve molecular resolution and functionality on large areas.
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Functionalized AFM probes for high speed force spectroscopy and microscopy
In this joint project between BFT and MTP we are attempting to develop functionalized AFM tips for application in high-speed spectroscopy and microscopy.
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New single molecule techniques for studying DNA-protein interactions
In this project we aim to develop and build a set-up in which it is possible to scan with a AFM tip or sharp knife edge along a suspended DNA molecule for the presence of bound proteins. The DNA molecule is attached between two polystyrene beads, one immobilized on a glass micropipette and the second one held in an optical trap.
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Dynamical aspects of structure and magnetism of ultrathin nanopatterns
The objective of this project is to observe and measure dynamics of surfaces with nanometer resolution using a spin-polarized low-energy electron microscope (SPLEEM).
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Piezo-electric microactuators for (parallel) nanoprobe systems
In the construction of mechanical micro- and nanodevices new actuator materials are extremely important. In this project we are exploring the deposition of different piezo-electric materials on different substrates, to assess whether we can use this to generate displacement and/or force in nanodevices.
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Nanopores for detecting individual DNA-protein interactions
A small nanopore with a diameter of 5 to 10 nm is used to detect the position of individual proteins as they are bound to the DNA molecule. Maintaining a constant voltage across the pore, and measuring the resulting current, allows detection of the molecule through the pore. At the moment a molecule passes a reduction in the current can be observed. An even larger reduction would be observed when a DNA-bound protein passes, as a result of the larger cross-section of the complex. From these current traces it is possible to accurately extract the location of the protein on the DNA molecule.
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