Development of biosensing probes for the study of parameters involved in migraine

Introduction

Migraine is a condition that is mainly characterized by severe headaches and nausea and of which attacks can last for several days. The prevalence of migraine in the western world is around 11 %, combined with the large impact of the condition on the daily life of patients and the fact that the mechanisms behind an attack are still poorly understood makes that migraine is an important condition for further study.

A migraine attack can be triggered by various stimuli like; light, sleep deprivation etc. After which the balance in the brain is disrupted and a cortical spreading depression (CSD) originates. A CSD is a transient wave that spreads thought the brain during which the brain is hyperactive followed by a phase of depolarization.

Research project

The research project is part of cooperation between three research groups that was initiated after the Spinoza award was handed out to Marin Scheffer, Michel Ferrari and Albert van den Berg. They decided to combine their experience in respectively mathematical modeling of critical transition, Migraine research and development of lab on a chip systems. The research project aims to develop tools to measure parameters involved in the onset and spreading CSD and develop models that can describe and predict the mechanisms behind migraine.

The Bios group is responsible in the project for the development of sensors and probes for testing in model mice. Critical points are the fabrication of miniaturized sensors so that with minimal invasive damage parameters can be measured in vivo and the selective functionalization of measurement sites to the parameters of interest.

Interested?

If you are interested in the research and would like to do a bachelor or master assignment in this topic you can contact via the contact info bellow:

Egbert van der Wouden

MESA+ Institute for Nanotechnology

University of Twente

Room: Carre 2.405

+31 (0)53 489 3944

e.j.vanderwouden@utwente.nl

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Home News & Highlights People Vacancies Research Education & Assignments Publications Intranet Internal Links External links Movies Sitemap Search	Emerging research topics \| Cells on chips \| Electrochemical systems \| Micro- and nanofluidics \| Nanosensing and Technology Development of biosensing probes for the study of parameters involved in migraine Introduction Migraine is a condition that is mainly characterized by severe headaches and nausea and of which attacks can last for several days. The prevalence of migraine in the western world is around 11 %, combined with the large impact of the condition on the daily life of patients and the fact that the mechanisms behind an attack are still poorly understood makes that migraine is an important condition for further study. A migraine attack can be triggered by various stimuli like; light, sleep deprivation etc. After which the balance in the brain is disrupted and a cortical spreading depression (CSD) originates. A CSD is a transient wave that spreads thought the brain during which the brain is hyperactive followed by a phase of depolarization. Research project The research project is part of cooperation between three research groups that was initiated after the Spinoza award was handed out to Marin Scheffer, Michel Ferrari and Albert van den Berg. They decided to combine their experience in respectively mathematical modeling of critical transition, Migraine research and development of lab on a chip systems. The research project aims to develop tools to measure parameters involved in the onset and spreading CSD and develop models that can describe and predict the mechanisms behind migraine. The Bios group is responsible in the project for the development of sensors and probes for testing in model mice. Critical points are the fabrication of miniaturized sensors so that with minimal invasive damage parameters can be measured in vivo and the selective functionalization of measurement sites to the parameters of interest. Interested? If you are interested in the research and would like to do a bachelor or master assignment in this topic you can contact via the contact info bellow: Egbert van der Wouden MESA+ Institute for Nanotechnology University of Twente Room: Carre 2.405 +31 (0)53 489 3944 e.j.vanderwouden@utwente.nl