BIOS-lecture: Peter Grootenhuis, October 28th 2010

!!!!!BIOS - Lecture!!!!!

WHO         : Peter Grootenhuis
COMPANY: Vertex Pharmaceuticals (San Diego)
DATE        : October 28th 2010
TIME         : 4 PM
PLACE      : 2.506

Drug Discovery and Development: A Long And Windy Road

It can take 10-12 years and over one billion dollars to discover and develop a new drug. What makes the drug discovery process so complex? In this lecture a concise overview will be given using the genetic disease cystic fibrosis as a test case. A collaboration between Vertex and the Cystic Fibrosis Foundation led to the discovery of several investigational drug candidates that are now in clinical studies. The lecture will highlight some of the challenges and milestones that are characteristic for the various phases in the drug discovery process.

Peter Grootenhuis, Ph.D.
Senior Director, Drug Innovation, Vertex Pharmaceuticals (San Diego)

Dr. Grootenhuis is Senior Director Drug Innovation at Vertex in San Diego. He supervises several medicinal and computational chemistry teams. In addition, he is project-leader of the sodium channel program. Prior to joining Vertex in 2002, Grootenhuis worked at CombiChem-DuPont in San Diego (1998-2002), and at Organon in the Netherlands (1989-1998). Before heading up the sodium channel program, Grootenhuis was project-leader of the cystic fibrosis project, which led to the discovery and IND filing of three drug candidates (VX-770, VX-809, VX-661) that are currently in clinical trials.

Grootenhuis performed post-doctoral studies at the UC San Francisco (1987-1989). He received a PhD and MSc in chemistry at the Universities of Twente and Utrecht, respectively. Currently he holds a part-time professorship chair in Virtual Screening and Design at the Free University at Amsterdam. He published over 100 peer reviewed papers and is an inventor of over 50 patents. He received several scientific awards, including the Gold Medal of the Royal Dutch Chemical Society in 1995 for the best chemist under 40 years of age. Grootenhuis served as Chairman of the ACS Computers in Chemistry Division.

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Home News & Highlights People Vacancies Research Education & Assignments Publications Intranet Internal Links External links Movies Sitemap Search	BIOS-lecture: Peter Grootenhuis, October 28th 2010 !!!!!BIOS - Lecture!!!!! WHO : Peter Grootenhuis COMPANY: Vertex Pharmaceuticals (San Diego) DATE : October 28th 2010 TIME : 4 PM PLACE : 2.506 Drug Discovery and Development: A Long And Windy Road It can take 10-12 years and over one billion dollars to discover and develop a new drug. What makes the drug discovery process so complex? In this lecture a concise overview will be given using the genetic disease cystic fibrosis as a test case. A collaboration between Vertex and the Cystic Fibrosis Foundation led to the discovery of several investigational drug candidates that are now in clinical studies. The lecture will highlight some of the challenges and milestones that are characteristic for the various phases in the drug discovery process. *Peter Grootenhuis, Ph.D.* *Senior Director, Drug Innovation, Vertex Pharmaceuticals (San Diego)* Dr. Grootenhuis is Senior Director Drug Innovation at Vertex in San Diego. He supervises several medicinal and computational chemistry teams. In addition, he is project-leader of the sodium channel program. Prior to joining Vertex in 2002, Grootenhuis worked at CombiChem-DuPont in San Diego (1998-2002), and at Organon in the Netherlands (1989-1998). Before heading up the sodium channel program, Grootenhuis was project-leader of the cystic fibrosis project, which led to the discovery and IND filing of three drug candidates (VX-770, VX-809, VX-661) that are currently in clinical trials. Grootenhuis performed post-doctoral studies at the UC San Francisco (1987-1989). He received a PhD and MSc in chemistry at the Universities of Twente and Utrecht, respectively. Currently he holds a part-time professorship chair in Virtual Screening and Design at the Free University at Amsterdam. He published over 100 peer reviewed papers and is an inventor of over 50 patents. He received several scientific awards, including the Gold Medal of the Royal Dutch Chemical Society in 1995 for the best chemist under 40 years of age. Grootenhuis served as Chairman of the ACS Computers in Chemistry Division.