Lab on a chip (121112)

Vakinformatie

Lab on a Chip (121112)

Studiejaar

2010

Taal vak

Engels

Vakbeschrijving

The Lab on a Chip course will take the student to the world of miniaturised systems used in various fields of chemistry and life sciences. A "Lab-on-a-Chip" consists of electrical, fluidic, and optical functions integrated in a microsystem, and has applications in (bio)chemical and medical fields. The core of the lab-on-a-chip system is a microfluidic channel structure, through which fluid sample plugs with less than a nanoliter volume are propelled by hydraulic electrokinetic or surface forces. The fluidic structures are machined in materials like fused silica, borofloat glass, or polymers. The course will discuss all aspects of such microsystems. After a thorough introduction on miniaturisation, the theoretical aspects of microfluidic principles are treated, followed by aspects of microfabrication and a visit to the cleanroom. The effect of miniaturisation on separation and detection forms the next chapter of the course. Surface modification and kinetics plays a vital role in increasing selectivity and efficiency of the device. How to make and use microarrays? Finally, all theory comes together in the practical examples presented as selected topics: applications of miniaturized diagnostic devices in clinical measurements and in life sciences, experiments on the micrometer to the nanometer scale, microreactors, manipulation and analysis of (living) cells and biomolecules. The course is aimed at MSc students of biomedical, electrical or chemical engineering.

Inhoud

Principles of fluidics at the micro and nanoscale; Microfabrication; Micro- and nanofluidic systems; Separation methods; Medical diagnostics on a chip; Detection methods on a chip (electrical, spectroscopic); Microreactors; Bioanalytical applications of microsystems; Cells on a chip;

Doel

To obtain understanding of the working principles, the basic elements and most relevant applications of micro- and nanotechnological systems.

Deeln. opleiding